Non-coding RNAs and epithelial mesenchymal transition in cancer: molecular mechanisms and clinical implications

Autor: Hashem Khanbabaei, Saeedeh Ebrahimi, Juan Luis García-Rodríguez, Zahra Ghasemi, Hossein Pourghadamyari, Milad Mohammadi, Lasse Sommer Kristensen

Publikováno v: Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-20 (2022)

Abstract Epithelial-mesenchymal transition (EMT) is a fundamental process for embryonic development during which epithelial cells acquire mesenchymal characteristics, and the underlying mechanisms confer malignant features to carcinoma cells such as

Externí odkaz: https://doaj.org/article/4e0f30a56942457c99619255eb096661

The transcriptional landscape and biomarker potential of circular RNAs in prostate cancer

Autor: Emma Bollmann Hansen, Jacob Fredsøe, Trine Line Hauge Okholm, Benedicte Parm Ulhøi, Søren Klingenberg, Jørgen Bjerggaard Jensen, Jørgen Kjems, Kirsten Bouchelouche, Michael Borre, Christian Kroun Damgaard, Jakob Skou Pedersen, Lasse Sommer Kristensen, Karina Dalsgaard Sørensen

Publikováno v: Genome Medicine, Vol 14, Iss 1, Pp 1-16 (2022)

Abstract Background Circular RNAs (circRNAs) constitute a largely unexplored source for biomarker discovery in prostate cancer (PC). Here, we characterize the biomarker potential of circRNAs in PC, where the need for novel diagnostic and prognostic t

Externí odkaz: https://doaj.org/article/bba9de18752249c5b95d7e52c150c49a

High-throughput RNA sequencing from paired lesional- and non-lesional skin reveals major alterations in the psoriasis circRNAome

Autor: Liviu-Ionut Moldovan, Thomas Birkballe Hansen, Morten Trillingsgaard Venø, Trine Line Hauge Okholm, Thomas Levin Andersen, Henrik Hager, Lars Iversen, Jørgen Kjems, Claus Johansen, Lasse Sommer Kristensen

Publikováno v: BMC Medical Genomics, Vol 12, Iss 1, Pp 1-17 (2019)

Abstract Background Psoriasis is a chronic inflammatory skin disease characterized by hyperproliferation and abnormal differentiation of keratinocytes. It is one of the most prevalent chronic inflammatory skin conditions in adults worldwide, with a c

Externí odkaz: https://doaj.org/article/e128b91bc28446c18746bdc4ef495a04

A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development

Autor: Sabine Seeler, Maria Schertz Andersen, Tamas Sztanka-Toth, Mateja Rybiczka-Tešulov, Marleen H. van den Munkhof, Chi-Chih Chang, Muyesier Maimaitili, Morten Trillingsgaard Venø, Thomas Birkballe Hansen, R. Jeroen Pasterkamp, Agnieszka Rybak-Wolf, Mark Denham, Nikolaus Rajewsky, Lasse Sommer Kristensen, Jørgen Kjems

Publikováno v: Seeler, S, Andersen, M S, Sztanka-Toth, T, Rybiczka-Tešulov, M, van den Munkhof, M H, Chang, C C, Maimaitili, M, Venø, M T, Hansen, T B, Pasterkamp, R J, Rybak-Wolf, A, Denham, M, Rajewsky, N, Kristensen, L S & Kjems, J 2023, ' A Circular RNA Expressed from the FAT3 Locus Regulates Neural Development ', Molecular Neurobiology, vol. 60, pp. 3239–3260 . https://doi.org/10.1007/s12035-023-03253-7

Circular RNAs (circRNAs) are key regulators of cellular processes, are abundant in the nervous system, and have putative regulatory roles during neural differentiation. However, the knowledge about circRNA functions in brain development is limited. H

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::654b9dfdd733d23a00cf61347ad87d4e
https://pure.au.dk/portal/da/publications/a-circular-rna-expressed-from-the-fat3-locus-regulates-neural-development(e73d6302-c507-4020-9962-5cbf3077cf5f).html

circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in small cell lung cancer

Autor: Doron Tolomeo, Debora Traversa, Santina Venuto, Karoline K. Ebbesen, Juan L. García Rodríguez, Grazia Tamma, Marianna Ranieri, Giorgia Simonetti, Martina Ghetti, Matteo Paganelli, Grazia Visci, Arcangelo Liso, Klaas Kok, Lucia Anna Muscarella, Federico Pio Fabrizio, Maria Antonia Frassanito, Aurelia Lamanuzzi, Ilaria Saltarella, Antonio Giovanni Solimando, Alessandro Fatica, Zaira Ianniello, René Massimiliano Marsano, Antonio Palazzo, Amalia Azzariti, Vito Longo, Stefania Tommasi, Domenico Galetta, Annamaria Catino, Alfredo Zito, Tommaso Mazza, Alessandro Napoli, Giovanni Martinelli, Jørgen Kjems, Lasse Sommer Kristensen, Angelo Vacca, Clelia Tiziana Storlazzi

Publikováno v: Genes Chromosomes and Cancer. Wiley
Tolomeo, D, Traversa, D, Venuto, S, Ebbesen, K, Garcia Rodriguez, J L, Tamma, G, Ranieri, M, Simonetti, G, Ghetti, M, Paganelli, M, Visci, G, Liso, A, Kok, K, Muscarella, L A, Fabrizio, F P, Frassanito, M A, Lamanuzzi, A, Saltarella, I, Solimando, A G, Fatica, A, Ianiello, Z, Marsano, R M, Palazzo, A, Azzariti, A, Longo, V, Tommasi, S, Galetta, D, Catino, A, ZIto, A, Mazza, T, Napoli, A, Martinelli, G, Kjems, J, Kristensen, L S, Vacca, A & Storlazzi, C T 2023, ' circPVT1 and PVT1/AKT3 show a role in cell proliferation, apoptosis, and tumor subtype-definition in Small Cell Lung Cancer ', Genes, Chromosomes & Cancer, vol. 62, no. 7, pp. 377-391 . https://doi.org/10.1002/gcc.23121

Small Cell Lung Cancer (SCLC) is treated as a homogeneous disease, although the expression of NEUROD1, ASCL1, POU2F3, and YAP1 identifies distinct molecular subtypes. The MYC oncogene, amplified in SCLC, was recently shown to act as a lineage-specifi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40db04445498364c91794a11b046764c
https://research.rug.nl/en/publications/fb27f467-19bc-432d-aa78-95dc980623af