Cyclic AMP Pathway Activation and Extracellular Zinc Induce Rapid Intracellular Zinc Mobilization in Candida albicans

Autor: Lasse Kjellerup, Anne-Marie L. Winther, Duncan Wilson, Anja T. Fuglsang

Publikováno v: Frontiers in Microbiology, Vol 9 (2018)

Zinc is an essential micronutrient, required for a range of zinc-dependent enzymes and transcription factors. In mammalian cells, zinc serves as a second messenger molecule. However, a role for zinc in signaling has not yet been established in the fu

Externí odkaz: https://doaj.org/article/81b8667472e44ce4a8c266722e37080e

Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives

Autor: Karen O'Hanlon Cohrt, Lasse Kjellerup, John Bondo Hansen, William Dalby-Brown, Anne-Marie Lund Winther, Johannes D. Clausen

Publikováno v: Clausen, J D, Kjellerup, L, Cohrt, K OH, Hansen, J B, Dalby-Brown, W & Winther, A-M L 2017, ' Elucidation of antimicrobial activity and mechanism of action by N-substituted carbazole derivatives ', Bioorganic & Medicinal Chemistry Letters, vol. 27, no. 19, pp. 4564-4570 . https://doi.org/10.1016/j.bmcl.2017.08.067
Bioorganic & Medicinal Chemistry Letters

Graphical abstract
Compounds belonging to a carbazole series have been identified as potent fungal plasma membrane proton adenosine triphophatase (H+-ATPase) inhibitors with a broad spectrum of antifungal activity. The carbazole compounds inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d7cd679d9f480980cb44ea43fc7b45d
https://doi.org/10.1016/j.bmcl.2017.08.067

Novel zinc-attenuating compounds as potent broad-spectrum antifungal agents with in vitro and in vivo efficacy

Autor: Laura Marín, Anne-Marie Lund Winther, Lasse Kjellerup, William Dalby-Brown, José Antonio Calera, Karen A. O'Hanlon Cohrt, Johannes D. Clausen

Publikováno v: GREDOS. Repositorio Institucional de la Universidad de Salamanca
instname
Antimicrobial Agents and Chemotherapy
Digital.CSIC. Repositorio Institucional del CSIC
Cohrt, K A OH, Marín, L, Kjellerup, L, Clausen, J D, Dalby-Brown, W, Antonio Calera, J & Winther, A-M L 2018, ' Novel zinc-attenuating compounds as potent broad-spectrum antifungal agents with In Vitro and In Vivo efficacy ', Antimicrobial Agents and Chemotherapy, vol. 62, no. 5, e02024-17 . https://doi.org/10.1128/AAC.02024-17

An increase in the incidence of rare but hard-to-treat invasive fungal pathogens as well as resistance to the currently available antifungal drugs calls for new broad-spectrum antifungals with a novel mechanism of action. Here we report the identific

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c177540d77100e16b977e5e30050db1
http://hdl.handle.net/10261/182769

Cyclic AMP Pathway Activation and Extracellular Zinc Induce Rapid Intracellular Zinc Mobilization in

Autor: Lasse, Kjellerup, Anne-Marie L, Winther, Duncan, Wilson, Anja T, Fuglsang

Publikováno v: Frontiers in Microbiology

Zinc is an essential micronutrient, required for a range of zinc-dependent enzymes and transcription factors. In mammalian cells, zinc serves as a second messenger molecule. However, a role for zinc in signaling has not yet been established in the fu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1b4cfafae117277b2a8680af245139b6
https://pubmed.ncbi.nlm.nih.gov/29619016

Identification of antifungal H+-ATPase inhibitors with effect on the plasma membrane potential

Autor: Karen O'Hanlon Cohrt, Sandra Gordon, Anja T. Fuglsang, Anne-Marie Lund Winther, William Dalby Brown, Lasse Kjellerup

Publikováno v: Kjellerup, L, Gordon, S, Cohrt, K OH, Brown, W D, Fuglsang, A T & Winther, A-M L 2017, ' Identification of antifungal H +-ATPase inhibitors with effect on the plasma membrane potential ', Antimicrobial Agents and Chemotherapy, vol. 61, no. 7, e00032-17 . https://doi.org/10.1128/AAC.00032-17
Antimicrobial Agents and Chemotherapy

The plasma membrane H + -ATPase (Pma1) is an essential fungal protein and a proposed target for new antifungal medications. The compounds in a small-molecule library containing ∼191,000 commercially available compounds were screened for their abili

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0824bf72e11b63e28b0853acbd6c7b07
https://curis.ku.dk/portal/da/publications/identification-of-antifungal-hatpase-inhibitors-with-effect-on-the-plasma-membrane-potential(3cc9b6d9-2d05-41f0-b5da-99bfc6aee5c3).html