Influence of Polyvinylpyrrolidone Molecular Weight and Concentration on the Precipitation Inhibition of Supersaturated Solutions of Poorly Soluble Drugs

Autor: Afnan Bany Odeh, Boushra El-Sayed, Matthias Manne Knopp, Thomas Rades, Lasse Ingerslev Blaabjerg

Publikováno v: Pharmaceutics, Vol 15, Iss 6, p 1601 (2023)

Supersaturating drug delivery systems such as solid dispersions of a drug in a polymer are frequently used in pharmaceutical development to enable oral delivery of poorly soluble drugs. In this study, the influence of the concentration and molecular

Externí odkaz: https://doaj.org/article/9f0b44c3424a47c4bb04908702ac93e4

Glass Forming Ability of Amorphous Drugs Investigated by Continuous Cooling and Isothermal Transformation

Autor: Lasse Ingerslev Blaabjerg, Thomas Rades, Holger Grohganz, Korbinian Löbmann, Eleanor Lindenberg

Publikováno v: Molecular Pharmaceutics. 13:3318-3325

The aim of this study was to investigate the glass forming ability of 12 different drugs by the determination of continuous cooling and isothermal transformation diagrams in order to elucidate if an inherent differentiation between the drugs with res

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a642e4feaf06b1de9831cd979b29b63
https://doi.org/10.1021/acs.molpharmaceut.6b00650

The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers

Autor: Anette Müllertz, Lasse Ingerslev Blaabjerg, Holger Grohganz, Korbinian Löbmann, Eleanor Lindenberg, Thomas Rades

Publikováno v: Blaabjerg, L I, Grohganz, H, Lindenberg, E, Löbmann, K, Mullertz, A & Rades, T 2018, ' The Influence of Polymers on the Supersaturation Potential of Poor and Good Glass Formers ', Pharmaceutics, vol. 10, no. 4, 164 . https://doi.org/10.3390/pharmaceutics10040164
Pharmaceutics
Volume 10
Issue 4
Pharmaceutics, Vol 10, Iss 4, p 164 (2018)

The increasing number of poorly water-soluble drug candidates in pharmaceutical development is a major challenge. Enabling techniques such as amorphization of the crystalline drug can result in supersaturation with respect to the thermodynamically mo

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb079eafa1882dfa7228180fe9362a9
https://curis.ku.dk/portal/da/publications/the-influence-of-polymers-on-the-supersaturation-potential-of-poor-and-good-glass-formers(c4ad81da-a1b3-4988-99a6-a24967056064).html

Preparation and characterization of spray-dried co-amorphous drug–amino acid salts

Autor: Lasse Ingerslev Blaabjerg, Korbinian Löbmann, Elisabeth Lenz, Katrine Tarp Jensen, Thomas Rades, Adam Bohr, Holger Grohganz, Peter Kleinebudde

Publikováno v: Journal of Pharmacy and Pharmacology. 68:615-624

Objectives Recently, co-amorphous drug–amino acid mixtures were introduced as a promising alternative to other amorphous stabilization approaches such as the use of polymers to form glass solutions. So far, these co-amorphous mixtures have been mai

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dec78fc9ee6f40aacd1fe14bbe6aac5
https://doi.org/10.1111/jphp.12458