An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

Autor: Thomas D. Madsen, Lasse H. Hansen, John Hintze, Zilu Ye, Shifa Jebari, Daniel B. Andersen, Hiren J. Joshi, Tongzhong Ju, Jens P. Goetze, Cesar Martin, Mette M. Rosenkilde, Jens J. Holst, Rune E. Kuhre, Christoffer K. Goth, Sergey Y. Vakhrushev, Katrine T. Schjoldager

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)

O-glycosylation is an abundant post-translational modification but its relevance for bioactive peptides is unclear. Here, the authors detect O-glycans on almost one third of the classified peptide hormones and show that O-glycosylation can modulate p

Externí odkaz: https://doaj.org/article/d81560792a8349198626ee05e6f9d81f

Circulating Concentrations of C-Type Natriuretic Peptides Increase with Sacubitril/Valsartan Treatment in Healthy Young Men

Autor: Simon Thonsgaard, Timothy C R Prickett, Lasse H Hansen, Nicolai J Wewer Albrechtsen, Ulrik Ø Andersen, Dijana Terzic, Peter Plomgaard, Finn Gustafsson, Jens P Goetze, Peter D Mark

Publikováno v: Thonsgaard, S, Prickett, T C R, Hansen, L H, Albrechtsen, N J W, Andersen, U Ø, Terzic, D, Plomgaard, P, Gustafsson, F, Goetze, J P & Mark, P D 2022, ' Circulating Concentrations of C-Type Natriuretic Peptides Increase with Sacubitril/Valsartan Treatment in Healthy Young Men ', Clinical Chemistry, vol. 68, no. 5, pp. 713–720 . https://doi.org/10.1093/clinchem/hvac005

Background C-type natriuretic peptide (CNP) is a cardioprotective peptide with high affinity for the ectoenzyme neutral endopeptidase (neprilysin). We aimed to determine whether angiotensin receptor-neprilysin inhibitor treatment acutely affects circ

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bf2bc3216fa17e724268bc532b92ed
https://curis.ku.dk/portal/da/publications/circulating-concentrations-of-ctype-natriuretic-peptides-increase-with-sacubitrilvalsartan-treatment-in-healthy-young-men(42576ba5-e9f4-4a35-be30-18bbafa50418).html

Augmented Reality for Subsurface Utility Engineering, Revisited

Autor: Dieter Schmalstieg, Philipp Fleck, Clemens Arth, Marco Stranner, Lasse H. Hansen

Publikováno v: Hansen, L H, Fleck, P, Stanner, M, Schmalstieg, D & Arth, C 2021, ' Augmented Reality for Subsurface Utility Engineering, Revisited ', I E E E Transactions on Visualization and Computer Graphics, vol. 27, no. 11, 21399443, pp. 4119-4128 . https://doi.org/10.1109/TVCG.2021.3106479

Civil engineering is a primary domain for new augmented reality technologies. In this work, the area of subsurface utility engineering is revisited, and new methods tackling well-known, yet unsolved problems are presented. We describe our solution to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe21d0d36525a6448abf2a404794ef0
https://vbn.aau.dk/da/publications/b6a338a5-2875-44b9-882c-f4ff439ccb90

An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles

Autor: Sergey Y. Vakhrushev, Zilu Ye, Jens P. Goetze, Mette M. Rosenkilde, Shifa Jebari, César Martín, Jens J. Holst, Tongzhong Ju, John Hintze, Lasse H Hansen, Daniel B. Andersen, Rune E. Kuhre, Katrine T. Schjoldager, Christoffer K. Goth, Thomas Daugbjerg Madsen, Hiren J. Joshi

Publikováno v: Madsen, T D, Hansen, L H, Hintze, J, Ye, Z, Jebari, S, Andersen, D B, Joshi, H J, Ju, T, Goetze, J P, Martin, C, Rosenkilde, M M, Holst, J J, Kuhre, R E, Goth, C K, Vakhrushev, S Y & Schjoldager, K T 2020, ' An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles ', Nature Communications, vol. 11, no. 1, 4033 . https://doi.org/10.1038/s41467-020-17473-1
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Addi. Archivo Digital para la Docencia y la Investigación
instname
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Universidad de Cantabria (UC)
Nature Communications

Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we execute a focused discovery strategy to provide an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa9985415adc543865afb20b97f3994
http://hdl.handle.net/10810/49183

Chromogranin A in the mammalian heart: expression without secretion

Autor: Lasse H Hansen, Jesper Hastrup Svendsen, Sergey Y. Vakhrushev, Kristoffer Mads Aaris Henningsen, Steen Pehrson, Katrine T. Schjoldager, Stine Darkner, Jens P. Goetze, Xu Chen

Publikováno v: Biomarkers in Medicine. 11:541-545

Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation. Materials & methods: Porcine cardiac tissue was analyzed for the presence of CgA-derived glycopeptides using a global O-glycoproteomic strategy. Blood was s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d55eccaa59b9df783a2200b7c8d28f9
https://doi.org/10.2217/bmm-2017-0052