Zobrazeno 1 - 10 of 31 pro vyhledávání: '"Lasse H Hansen"'
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Akademický článek
The non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist.
Autor: Christian Berg, Michael J Wedemeyer, Motiejus Melynis, Roman R Schlimgen, Lasse H Hansen, Jon Våbenø, Francis C Peterson, Brian F Volkman, Mette M Rosenkilde, Hans R Lüttichau
Publikováno v: PLoS Pathogens, Vol 18, Iss 3, p e1010355 (2022)
Human cytomegalovirus (HCMV) is a major pathogen in immunocompromised patients. The UL146 gene exists as 14 diverse genotypes among clinical isolates, which encode 14 different CXC chemokines. One genotype (vCXCL1GT1) is a known agonist for CXCR1 and
Externí odkaz: https://doaj.org/article/b58f3e9f294b4bb682ffd33432ab9a5c
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2
Akademický článek
An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
Autor: Thomas D. Madsen, Lasse H. Hansen, John Hintze, Zilu Ye, Shifa Jebari, Daniel B. Andersen, Hiren J. Joshi, Tongzhong Ju, Jens P. Goetze, Cesar Martin, Mette M. Rosenkilde, Jens J. Holst, Rune E. Kuhre, Christoffer K. Goth, Sergey Y. Vakhrushev, Katrine T. Schjoldager
Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
O-glycosylation is an abundant post-translational modification but its relevance for bioactive peptides is unclear. Here, the authors detect O-glycans on almost one third of the classified peptide hormones and show that O-glycosylation can modulate p
Externí odkaz: https://doaj.org/article/d81560792a8349198626ee05e6f9d81f
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3
Circulating Concentrations of C-Type Natriuretic Peptides Increase with Sacubitril/Valsartan Treatment in Healthy Young Men
Autor: Simon Thonsgaard, Timothy C R Prickett, Lasse H Hansen, Nicolai J Wewer Albrechtsen, Ulrik Ø Andersen, Dijana Terzic, Peter Plomgaard, Finn Gustafsson, Jens P Goetze, Peter D Mark
Publikováno v: Thonsgaard, S, Prickett, T C R, Hansen, L H, Albrechtsen, N J W, Andersen, U Ø, Terzic, D, Plomgaard, P, Gustafsson, F, Goetze, J P & Mark, P D 2022, ' Circulating Concentrations of C-Type Natriuretic Peptides Increase with Sacubitril/Valsartan Treatment in Healthy Young Men ', Clinical Chemistry, vol. 68, no. 5, pp. 713–720 . https://doi.org/10.1093/clinchem/hvac005
Background C-type natriuretic peptide (CNP) is a cardioprotective peptide with high affinity for the ectoenzyme neutral endopeptidase (neprilysin). We aimed to determine whether angiotensin receptor-neprilysin inhibitor treatment acutely affects circ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4bf2bc3216fa17e724268bc532b92ed
https://curis.ku.dk/portal/da/publications/circulating-concentrations-of-ctype-natriuretic-peptides-increase-with-sacubitrilvalsartan-treatment-in-healthy-young-men(42576ba5-e9f4-4a35-be30-18bbafa50418).html
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4
Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism
Autor: Peter D Mark, Katrine D. Galsgaard, Jens J. Holst, Steve M. Mongovin, Hannelouise Kissow, Carolyn F. Deacon, Lasse H Hansen, Ellen E. Blaak, Frederik Ceutz, Gijs H. Goossens, Mette M. Rosenkilde, Marie Winther-Sørensen, Dijana Terzic, Nicolai J. Wewer Albrechtsen, Sakeneh Zraika, Peter Plomgaard, Sasha A.S. Kjeldsen, Jens P. Goetze, Jenna Hunt, Nathalie Esser
Publikováno v: Kjeldsen, S A S, Hansen, L H, Esser, N, Mongovin, S, Winther-Sørensen, M, Galsgaard, K D, Hunt, J E, Kissow, H, Ceutz, F R, Terzic, D, Mark, P D, Plomgaard, P, Goetze, J P, Goossens, G H, Blaak, E E, Deacon, C F, Rosenkilde, M M, Zraika, S, Holst, J J & Wewer Albrechtsen, N J 2021, ' Neprilysin Inhibition Increases Glucagon Levels in Humans and Mice With Potential Effects on Amino Acid Metabolism ', Endocrine Research, vol. 5, no. 9, bvab084 . https://doi.org/10.1210/jendso/bvab084
Journal of the Endocrine Society
Journal of the endocrine society, 5(9):bvab084. Oxford University Press
Context Inhibitors of the protease neprilysin (NEP) are used for treating heart failure, but are also linked to improvements in metabolism. NEP may cleave proglucagon-derived peptides, including the glucose and amino acid (AA)-regulating hormone gluc
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed172e2542e13a8fd49373b885d6c29d
https://cris.maastrichtuniversity.nl/en/publications/d32b3743-f77c-422e-b9af-62513fcd134a
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5
Augmented Reality for Subsurface Utility Engineering, Revisited
Autor: Dieter Schmalstieg, Philipp Fleck, Clemens Arth, Marco Stranner, Lasse H. Hansen
Publikováno v: Hansen, L H, Fleck, P, Stanner, M, Schmalstieg, D & Arth, C 2021, ' Augmented Reality for Subsurface Utility Engineering, Revisited ', I E E E Transactions on Visualization and Computer Graphics, vol. 27, no. 11, 21399443, pp. 4119-4128 . https://doi.org/10.1109/TVCG.2021.3106479
Civil engineering is a primary domain for new augmented reality technologies. In this work, the area of subsurface utility engineering is revisited, and new methods tackling well-known, yet unsolved problems are presented. We describe our solution to
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe21d0d36525a6448abf2a404794ef0
https://vbn.aau.dk/da/publications/b6a338a5-2875-44b9-882c-f4ff439ccb90
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6
Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor
Autor: Jens P. Goetze, Henrik Clausen, Christoffer K. Goth, Thomas Daugbjerg Madsen, John C. Burnett, Jens F. Rehfeld, Sergey Y. Vakhrushev, Katrine T. Schjoldager, S. Jeson Sangaralingham, Seethalakshmi R. Iyer, Nina Dzhoyashvili, Lasse H Hansen, Yang Chen
Publikováno v: Hansen, L H, Madsen, T D, Goth, C K, Clausen, H, Chen, Y, Dzhoyashvili, N, Iyer, S R, Sangaralingham, S J, Burnett, J C, Rehfeld, J F, Vakhrushev, S Y, Schjoldager, K T & Goetze, J P 2019, ' Discovery of O-glycans on atrial natriuretic peptide (ANP) that affect both its proteolytic degradation and potency at its cognate receptor ', Journal of Biological Chemistry, vol. 294, no. 34, pp. 12567-12578 . https://doi.org/10.1074/jbc.RA119.008102
Atrial natriuretic peptide (ANP) is a peptide hormone that in response to atrial stretch is secreted from atrial myocytes into the circulation, where it stimulates vasodilatation and natriuresis. ANP is an important biomarker of heart failure where l
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::696bc8085a4d0619e231c5a06ad94e0c
https://doi.org/10.1074/jbc.ra119.008102
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7
An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles
Autor: Sergey Y. Vakhrushev, Zilu Ye, Jens P. Goetze, Mette M. Rosenkilde, Shifa Jebari, César Martín, Jens J. Holst, Tongzhong Ju, John Hintze, Lasse H Hansen, Daniel B. Andersen, Rune E. Kuhre, Katrine T. Schjoldager, Christoffer K. Goth, Thomas Daugbjerg Madsen, Hiren J. Joshi
Publikováno v: Madsen, T D, Hansen, L H, Hintze, J, Ye, Z, Jebari, S, Andersen, D B, Joshi, H J, Ju, T, Goetze, J P, Martin, C, Rosenkilde, M M, Holst, J J, Kuhre, R E, Goth, C K, Vakhrushev, S Y & Schjoldager, K T 2020, ' An atlas of O-linked glycosylation on peptide hormones reveals diverse biological roles ', Nature Communications, vol. 11, no. 1, 4033 . https://doi.org/10.1038/s41467-020-17473-1
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Addi. Archivo Digital para la Docencia y la Investigación
instname
Addi: Archivo Digital para la Docencia y la Investigación
Universidad del País Vasco
Universidad de Cantabria (UC)
Nature Communications
Peptide hormones and neuropeptides encompass a large class of bioactive peptides that regulate physiological processes like anxiety, blood glucose, appetite, inflammation and blood pressure. Here, we execute a focused discovery strategy to provide an
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8fa9985415adc543865afb20b97f3994
http://hdl.handle.net/10810/49183
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9
Chromogranin A in the mammalian heart: expression without secretion
Autor: Lasse H Hansen, Jesper Hastrup Svendsen, Sergey Y. Vakhrushev, Kristoffer Mads Aaris Henningsen, Steen Pehrson, Katrine T. Schjoldager, Stine Darkner, Jens P. Goetze, Xu Chen
Publikováno v: Biomarkers in Medicine. 11:541-545
Aim: To investigate whether chromogranin A (CgA) is secreted from the heart into circulation. Materials & methods: Porcine cardiac tissue was analyzed for the presence of CgA-derived glycopeptides using a global O-glycoproteomic strategy. Blood was s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d55eccaa59b9df783a2200b7c8d28f9
https://doi.org/10.2217/bmm-2017-0052
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10
Site-specific O-Glycosylation by Polypeptide N-Acetylgalactosaminyltransferase 2 (GalNAc-transferase T2) Co-regulates β1-Adrenergic Receptor N-terminal Cleavage
Autor: Henrik Clausen, Jarkko J. Lackman, Hamayun Khan, Christopher M. Overall, Ulla E. Petäjä-Repo, Yoshiki Narimatsu, Hanna E. Tuhkanen, Lasse H Hansen, Katrine T. Schjoldager, Christoffer K. Goth, Shengjun Wang
Publikováno v: Journal of Biological Chemistry. 292:4714-4726
The β1-adrenergic receptor (β1AR) is a G protein-coupled receptor (GPCR) and the predominant adrenergic receptor subtype in the heart, where it mediates cardiac contractility and the force of contraction. Although it is the most important target fo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e65b2be8cc4f1580f0de7862da52f93f
https://doi.org/10.1074/jbc.m116.730614
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