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pro vyhledávání: '"Lasse H, Lauridsen"'
Autor:
Lucile Crouzier, Camille Dubois, Stacey L Edwards, Lasse H Lauridsen, Jesper Wengel, Rakesh N Veedu
Publikováno v:
PLoS ONE, Vol 7, Iss 4, p e35990 (2012)
BACKGROUND: Modified nucleotides are increasingly being utilized in the de novo selection of aptamers for enhancing their drug-like character and abolishing the need for time consuming trial-and-error based post-selection modifications. Locked nuclei
Externí odkaz:
https://doaj.org/article/72a21a7a841346adba5a7a8268f39961
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41702 (2012)
BACKGROUND: Nucleic acids based therapeutic approaches have gained significant interest in recent years towards the development of therapeutics against many diseases. Recently, research on aptamers led to the marketing of Macugen®, an inhibitor of v
Externí odkaz:
https://doaj.org/article/7e42835c7241429bbb60a79b1b9f1f0d
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1671
In vitro selection of aptamers that recognize small organic molecules has proven difficult, in part due to the challenge of immobilizing small molecules on solid supports for SELEX (Systematic Evolution of Ligands by Exponential Enrichment). This stu