Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lasse E. Pedersen"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
Bispecific antibodies (bsAbs) have attracted significant attention due to their dual binding activity, which permits simultaneous targeting of antigens and synergistic binding effects beyond what can be obtained even with combinations of conventional
Externí odkaz:
https://doaj.org/article/a4b23ed1248a4239a8d104176d46cb43
Autor:
Oscar Mejias-Gomez, Andreas V. Madsen, Kerstin Skovgaard, Lasse E. Pedersen, J. Preben Morth, Timothy P. Jenkins, Peter Kristensen, Steffen Goletz
Publikováno v:
mAbs, Vol 15, Iss 1 (2023)
ABSTRACTThe human immune system uses antibodies to neutralize foreign antigens. They are composed of heavy and light chains, both with constant and variable regions. The variable region has six hypervariable loops, also known as complementary-determi
Externí odkaz:
https://doaj.org/article/457ebf9018dd4c70bbe8e1d0e7fa743e
Publikováno v:
Mejias-Gomez, O, Madsen, A V, Pedersen, L E, Kristensen, P & Goletz, S 2023, ' Eliminating OFF-Frame Clones in Randomized Gene Libraries: An Improved Split β-Lactamase Enrichment System ', New Biotechnology, vol. 75, pp. 13-20 . https://doi.org/10.1016/j.nbt.2023.03.002
Mejias-Gomez, O, Madsen, A V, Pedersen, L E, Kristensen, P & Goletz, S 2023, ' Eliminating OFF-Frame Clones in Randomized Gene Libraries : An Improved Split β-Lactamase Enrichment System ', New Biotechnology, vol. 75, pp. 13-20 . https://doi.org/10.1016/j.nbt.2023.03.002
Mejias-Gomez, O, Madsen, A V, Pedersen, L E, Kristensen, P & Goletz, S 2023, ' Eliminating OFF-Frame Clones in Randomized Gene Libraries : An Improved Split β-Lactamase Enrichment System ', New Biotechnology, vol. 75, pp. 13-20 . https://doi.org/10.1016/j.nbt.2023.03.002
Large, randomized libraries are a key technology for many biotechnological applications. While genetic diversity is the main parameter most libraries direct their resources on, less focus is devoted to ensuring functional IN-frame expression. This st
Autor:
Johan B. Rojek, Yogesh Basavaraju, Saranya Nallapareddy, Dubhe B. Bulté, Roland Baumgartner, Sanne Schoffelen, Lise M. Grav, Steffen Goletz, Lasse E. Pedersen
Publikováno v:
Rojek, J B, Basavaraju, Y, Nallapareddy, S, Ocaña, D B B, Baumgartner, R, Schoffelen, S, Grav, L M, Goletz, S & Pedersen, L E 2023, ' Expanding the CRISPR toolbox for Chinese hamster ovary cells with comprehensive tools for Mad7 genome editing ', Biotechnology and Bioengineering, vol. 120, no. 6, pp. 1478-1491 . https://doi.org/10.1002/bit.28367
The production of high-value biopharmaceuticals is dominated by mammalian production cells, particularly Chinese Hamster Ovary (CHO) cells, which have been widely used and preferred in manufacturing processes. The discovery of CRISPR-Cas9 significant
Autor:
Rebecca M. Lennen, Hyun Gyu Lim, Kristian Jensen, Elsayed T. Mohammed, Patrick V. Phaneuf, Myung Hyun Noh, Sailesh Malla, Rosa A. Börner, Ksenia Chekina, Emre Özdemir, Ida Bonde, Anna Koza, Jérôme Maury, Lasse E. Pedersen, Lars Y. Schöning, Nikolaus Sonnenschein, Bernhard O. Palsson, Alex T. Nielsen, Morten O.A. Sommer, Markus J. Herrgård, Adam M. Feist
Publikováno v:
Lennen, R M, Lim, H G, Jensen, K, Mohammed, E T, Phaneuf, P V, Noh, M H, Malla, S, Börner, R A, Chekina, K, Özdemir, E, Bonde, I, Koza, A, Maury, J, Pedersen, L E, Schöning, L Y, Sonnenschein, N, Palsson, B O, Nielsen, A T, Sommer, M O A, Herrgård, M J & Feist, A M 2023, ' Laboratory evolution reveals general and specific tolerance mechanisms for commodity chemicals ', Metabolic Engineering, vol. 76, pp. 179-192 . https://doi.org/10.1016/j.ymben.2023.01.012
Although strain tolerance to high product concentrations is a barrier to the economically viable biomanufacturing of industrial chemicals, chemical tolerance mechanisms are often unknown. To reveal tolerance mechanisms, an automated platform was util
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eef3b3ec046b6eb72590ff507703662
https://orbit.dtu.dk/en/publications/17e1f922-158c-4009-be96-42432c05ae98
https://orbit.dtu.dk/en/publications/17e1f922-158c-4009-be96-42432c05ae98
Autor:
Nicolas Bruffaerts, Lasse E Pedersen, Gaëlle Vandermeulen, Véronique Préat, Norbert Stockhofe-Zurwieden, Kris Huygen, Marta Romano
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0132288 (2015)
The only tuberculosis vaccine currently available, bacille Calmette-Guérin (BCG) is a poor inducer of CD8(+) T cells, which are particularly important for the control of latent tuberculosis and protection against reactivation. As the induction of st
Externí odkaz:
https://doaj.org/article/db9de80c894e476b8e3e3783b412d6e1
Autor:
Lasse E, Pedersen, Jared R, Patch, Mary, Kenney, Raisa A, Glabman, Morten, Nielsen, Gregers, Jungersen, Soren, Buus, William T, Golde
Publikováno v:
Veterinary immunology and immunopathology. 181
The immune response to the highly acute foot-and-mouth disease virus (FMDV) is routinely reported as a measure of serum antibody. However, a critical effector function of immune responses combating viral infection of mammals is the cytotoxic T lympho