Antiviral lectin Q-Griffithsin suppresses fungal infection in murine models of vaginal candidiasis.

Autor: Nabeta HW; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville KY, United States.; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville KY, United States., Lasnik AB; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville KY, United States., Fuqua JL; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville KY, United States.; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville KY, United States., Wang L; Infectious Diseases, Magee-Womens Research Institute, Pittsburgh, PA, United States., Rohan LC; Infectious Diseases, Magee-Womens Research Institute, Pittsburgh, PA, United States.; Department of Obstetrics, Gynecology, & Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA, United States.; Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, PA, United States., Palmer KE; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville KY, United States.; Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville KY, United States.; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville KY, United States.

Publikováno v: Frontiers in cellular and infection microbiology [Front Cell Infect Microbiol] 2022 Oct 18; Vol. 12, pp. 976033. Date of Electronic Publication: 2022 Oct 18 (Print Publication: 2022).

Induction of interferon response by high viral loads at early stage infection may protect against severe outcomes in COVID-19 patients.

Autor: Rouchka EC; Department of Computer Science and Engineering, University of Louisville, Louisville, KY, USA.; Kentucky IDeA Network of Biomedical Research Excellence (KY-INBRE) Bioinformatics Core, Louisville, KY, USA., Chariker JH; Kentucky IDeA Network of Biomedical Research Excellence (KY-INBRE) Bioinformatics Core, Louisville, KY, USA.; Department of Neuroscience Training, University of Louisville, Louisville, KY, USA., Alejandro B; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, USA., Adcock RS; Center for Predictive Medicine, University of Louisville School of Medicine, Louisville, KY, USA., Singhal R; Kentucky IDeA Network of Biomedical Research Excellence (KY-INBRE) Bioinformatics Core, Louisville, KY, USA.; Department of Medicine, University of Louisville, Louisville, KY, USA., Ramirez J; Department of Medicine, University of Louisville, Louisville, KY, USA.; Division of Infectious Diseases, University of Louisville, Louisville, KY, USA., Palmer KE; Center for Predictive Medicine, University of Louisville School of Medicine, Louisville, KY, USA.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA., Lasnik AB; Center for Predictive Medicine, University of Louisville School of Medicine, Louisville, KY, USA.; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA., Carrico R; Department of Medicine, University of Louisville, Louisville, KY, USA.; Division of Infectious Diseases, University of Louisville, Louisville, KY, USA., Arnold FW; Department of Medicine, University of Louisville, Louisville, KY, USA.; Division of Infectious Diseases, University of Louisville, Louisville, KY, USA., Furmanek S; Department of Medicine, University of Louisville, Louisville, KY, USA.; Division of Infectious Diseases, University of Louisville, Louisville, KY, USA., Zhang M; Department of Medicine, University of Louisville, Louisville, KY, USA.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.; Genomics Core Facility, University of Louisville, Louisville, KY, USA., Wolf LA; Division of Infectious Diseases, University of Louisville, Louisville, KY, USA., Waigel S; Department of Medicine, University of Louisville, Louisville, KY, USA.; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.; Genomics Core Facility, University of Louisville, Louisville, KY, USA., Zacharias W; Department of Medicine, University of Louisville, Louisville, KY, USA.; Department of Pharmacology and Toxicology, University of Louisville, Louisville, KY, USA.; James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.; Genomics Core Facility, University of Louisville, Louisville, KY, USA., Bordon J; Washington Health Institute, George Washington University School of Medicine, Washington, D.C, USA.; Department of Medicine, George Washington University School of Medicine, Washington, D.C, USA., Chung D; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, KY, USA. hoon.chung@louisville.edu.; Center for Predictive Medicine, University of Louisville School of Medicine, Louisville, KY, USA. hoon.chung@louisville.edu.

Publikováno v: Scientific reports [Sci Rep] 2021 Aug 03; Vol. 11 (1), pp. 15715. Date of Electronic Publication: 2021 Aug 03.

Rapid-Release Griffithsin Fibers for Dual Prevention of HSV-2 and HIV-1 Infections.

Autor: Tyo KM; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.; Center for Predictive Medicine, Louisville, Kentucky, USA., Lasnik AB; Center for Predictive Medicine, Louisville, Kentucky, USA., Zhang L; Center for Predictive Medicine, Louisville, Kentucky, USA.; Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, Kentucky, USA., Jenson AB; James Graham Brown Cancer Center, University of Louisville School of Medicine, University of Louisville, Louisville, Kentucky, USA., Fuqua JL; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.; Center for Predictive Medicine, Louisville, Kentucky, USA., Palmer KE; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.; Center for Predictive Medicine, Louisville, Kentucky, USA.; James Graham Brown Cancer Center, University of Louisville School of Medicine, University of Louisville, Louisville, Kentucky, USA.; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, USA., Steinbach-Rankins JM; Department of Pharmacology and Toxicology, School of Medicine, University of Louisville, Louisville, Kentucky, USA jill.steinbach@louisville.edu.; Center for Predictive Medicine, Louisville, Kentucky, USA.; Department of Bioengineering, Speed School of Engineering, University of Louisville, Louisville, Kentucky, USA.; James Graham Brown Cancer Center, University of Louisville School of Medicine, University of Louisville, Louisville, Kentucky, USA.; Department of Microbiology and Immunology, School of Medicine, University of Louisville, Louisville, Kentucky, USA.

Publikováno v: Antimicrobial agents and chemotherapy [Antimicrob Agents Chemother] 2020 May 21; Vol. 64 (6). Date of Electronic Publication: 2020 May 21 (Print Publication: 2020).

Studies in a Murine Model Confirm the Safety of Griffithsin and Advocate Its Further Development as a Microbicide Targeting HIV-1 and Other Enveloped Viruses.

Autor: Kouokam JC; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, University of Louisville, Louisville, KY 40202, USA. j0kouo01@louisville.edu., Lasnik AB; James Graham Brown Cancer Center, University of Louisville School of Medicine, University of Louisville, Louisville, KY 40202, USA. amanda.lasnik@louisville.edu., Palmer KE; Department of Pharmacology and Toxicology, University of Louisville School of Medicine, University of Louisville, Louisville, KY 40202, USA. kenneth.palmer@louisville.edu.; James Graham Brown Cancer Center, University of Louisville School of Medicine, University of Louisville, Louisville, KY 40202, USA. kenneth.palmer@louisville.edu.; Center for Predictive Medicine, University of Louisville, Louisville, KY 40202, USA. kenneth.palmer@louisville.edu.

Publikováno v: Viruses [Viruses] 2016 Nov 17; Vol. 8 (11). Date of Electronic Publication: 2016 Nov 17.

Occluding the mannose moieties on human immunodeficiency virus type 1 gp120 with griffithsin improves the antibody responses to both proteins in mice.

Autor: Banerjee K; Department of Microbiology and Immunology, Weill Cornell Medical College, New York, New York 10021, USA., Michael E, Eggink D, van Montfort T, Lasnik AB, Palmer KE, Sanders RW, Moore JP, Klasse PJ

Publikováno v: AIDS research and human retroviruses [AIDS Res Hum Retroviruses] 2012 Feb; Vol. 28 (2), pp. 206-14. Date of Electronic Publication: 2011 Jul 27.