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TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.

Autor: Zhang Y; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Desai A; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Yang SY; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Gastroenterology, Haeundae Paik Hospital, Inje University, Busan 612896, South Korea., Bae KB; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Surgery, Busan Paik Hospital, and Paik Institute of Clinical Research and Ocular Neovascular Research Center, Inje University, Busan, South Korea., Antczak MI; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Fink SP; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Tiwari S; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA., Willis JE; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA., Williams NS; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Dawson DM; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA., Wald D; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA., Chen WD; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Wang Z; Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA., Kasturi L; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Larusch GA; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., He L; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Cominelli F; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA., Di Martino L; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Djuric Z; Department of Family Medicine, University of Michigan, Ann Arbor MI 48109, USA., Milne GL; Department of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA., Chance M; Proteomics Center, Case Western Reserve University, Cleveland, OH 44106, USA., Sanabria J; Department of Surgery, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA., Dealwis C; Department of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA., Mikkola D; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Naidoo J; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Wei S; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA., Tai HH; College of Pharmacy, University of Kentucky, Lexington, KY 40536, USA., Gerson SL; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu., Ready JM; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu., Posner B; Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu., Willson JK; Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu., Markowitz SD; Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu.

Publikováno v: Science (New York, N.Y.) [Science] 2015 Jun 12; Vol. 348 (6240), pp. aaa2340.

Domain 2 of uPAR regulates single-chain urokinase-mediated angiogenesis through β1-integrin and VEGFR2.

Autor: Larusch GA; Division of Hematology and Oncology, Department of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA., Merkulova A, Mahdi F, Shariat-Madar Z, Sitrin RG, Cines DB, Schmaier AH

Publikováno v: American journal of physiology. Heart and circulatory physiology [Am J Physiol Heart Circ Physiol] 2013 Aug 01; Vol. 305 (3), pp. H305-20. Date of Electronic Publication: 2013 May 24.

Murine prolylcarboxypeptidase depletion induces vascular dysfunction with hypertension and faster arterial thrombosis.

Autor: Adams GN; Department of Medicine, Hematology and Oncology Division, Case Western Reserve University, 10900 Euclid Avenue, Cleveland, OH 44106-7284, USA., LaRusch GA, Stavrou E, Zhou Y, Nieman MT, Jacobs GH, Cui Y, Lu Y, Jain MK, Mahdi F, Shariat-Madar Z, Okada Y, D'Alecy LG, Schmaier AH

Publikováno v: Blood [Blood] 2011 Apr 07; Vol. 117 (14), pp. 3929-37. Date of Electronic Publication: 2011 Feb 04.

Nutlin3 blocks vascular endothelial growth factor induction by preventing the interaction between hypoxia inducible factor 1alpha and Hdm2.

Autor: LaRusch GA; Department of Radiation Oncology, Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio, USA., Jackson MW, Dunbar JD, Warren RS, Donner DB, Mayo LD

Publikováno v: Cancer research [Cancer Res] 2007 Jan 15; Vol. 67 (2), pp. 450-4.