Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet

Autor: Penke, Melanie, Larsen, Per S., Schuster, Susanne, Dall, Morten, Jensen, Benjamin A.H., Gorski, Theresa, Meusel, Andrej, Richter, Sandy, Vienberg, Sara G., Treebak, Jonas T., Kiess, Wieland, Garten, Antje

Nicotinamide phosphoribosyltransferase (Nampt) is the rate-limiting enzyme for NAD salvage and the abundance of Nampt has been shown to be altered in non-alcoholic fatty liver disease. It is, however, unknown how hepatic Nampt is regulated in respons

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Hepatic NAD salvage pathway is enhanced in mice on a high-fat diet.

Autor: Penke M; Center for Pediatric Research Leipzig (CPL), University Hospital for Children & Adolescents, University of Leipzig, Liebigstr. 21, 04103 Leipzig, Germany; LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthalstr. 27, D-04103 Leipzig, Germany. Electronic address: melanie.penke@medizin.uni-leipzig.de., Larsen PS; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Schuster S; Center for Pediatric Research Leipzig (CPL), University Hospital for Children & Adolescents, University of Leipzig, Liebigstr. 21, 04103 Leipzig, Germany; LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthalstr. 27, D-04103 Leipzig, Germany., Dall M; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Jensen BA; Department of Biology, Laboratory for Genomics and Molecular Biomedicine, Faculty of Science, University of Copenhagen, Copenhagen, Denmark., Gorski T; Center for Pediatric Research Leipzig (CPL), University Hospital for Children & Adolescents, University of Leipzig, Liebigstr. 21, 04103 Leipzig, Germany., Meusel A; Department of Biology, Laboratory for Genomics and Molecular Biomedicine, Faculty of Science, University of Copenhagen, Copenhagen, Denmark; Institut für Medizinische Physik und Biophysik, University of Leipzig, Härtelstr. 16-18, 04107 Leipzig, Germany., Richter S; Center for Pediatric Research Leipzig (CPL), University Hospital for Children & Adolescents, University of Leipzig, Liebigstr. 21, 04103 Leipzig, Germany., Vienberg SG; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Treebak JT; The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Integrative Physiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark., Kiess W; Center for Pediatric Research Leipzig (CPL), University Hospital for Children & Adolescents, University of Leipzig, Liebigstr. 21, 04103 Leipzig, Germany; LIFE Leipzig Research Centre for Civilization Diseases, University of Leipzig, Philipp-Rosenthalstr. 27, D-04103 Leipzig, Germany., Garten A; Center for Pediatric Research Leipzig (CPL), University Hospital for Children & Adolescents, University of Leipzig, Liebigstr. 21, 04103 Leipzig, Germany.

Publikováno v: Molecular and cellular endocrinology [Mol Cell Endocrinol] 2015 Sep 05; Vol. 412, pp. 65-72. Date of Electronic Publication: 2015 May 29.