APOBEC3A/B deletion polymorphism and endometrial cancer risk

Autor: Nigar Sofiyeva, Camilla Krakstad, Mari K. Halle, Tracy A. O'Mara, Pål Romundstad, Kristian Hveem, Lars Vatten, Per E. Lønning, Liv B. Gansmo, Stian Knappskog

Publikováno v: Cancer Medicine, Vol 12, Iss 6, Pp 6659-6667 (2023)

Abstract Background A common 30 kb deletion affecting the APOBEC3A and APOBEC3B genes has been linked to increased APOBEC activity and APOBEC‐related mutational signatures in human cancers. The role of this deletion as a cancer risk factor remains

Externí odkaz: https://doaj.org/article/4ceaeac0dc614338b1f48747cdc9b398

Circulating sex hormones in relation to anthropometric, sociodemographic and behavioural factors in an international dataset of 12,300 men.

Autor: Eleanor L Watts, Paul N Appleby, Demetrius Albanes, Amanda Black, June M Chan, Chu Chen, Piera M Cirillo, Barbara A Cohn, Michael B Cook, Jenny L Donovan, Luigi Ferrucci, Cedric F Garland, Graham G Giles, Phyllis J Goodman, Laurel A Habel, Christopher A Haiman, Jeff M P Holly, Robert N Hoover, Rudolf Kaaks, Paul Knekt, Laurence N Kolonel, Tatsuhiko Kubo, Loïc Le Marchand, Tapio Luostarinen, Robert J MacInnis, Hanna O Mäenpää, Satu Männistö, E Jeffrey Metter, Roger L Milne, Abraham M Y Nomura, Steven E Oliver, J Kellogg Parsons, Petra H Peeters, Elizabeth A Platz, Elio Riboli, Fulvio Ricceri, Sabina Rinaldi, Harri Rissanen, Norie Sawada, Catherine A Schaefer, Jeannette M Schenk, Frank Z Stanczyk, Meir Stampfer, Pär Stattin, Ulf-Håkan Stenman, Anne Tjønneland, Antonia Trichopoulou, Ian M Thompson, Shoichiro Tsugane, Lars Vatten, Alice S Whittemore, Regina G Ziegler, Naomi E Allen, Timothy J Key, Ruth C Travis

Publikováno v: PLoS ONE, Vol 12, Iss 12, p e0187741 (2017)

IntroductionSex hormones have been implicated in the etiology of a number of diseases. To better understand disease etiology and the mechanisms of disease-risk factor associations, this analysis aimed to investigate the associations of anthropometric

Externí odkaz: https://doaj.org/article/220b20dddc614ed5b5cb7519e7c7fb1c

Using prior information from the medical literature in GWAS of oral cancer identifies novel susceptibility variant on chromosome 4--the AdAPT method.

Autor: Mattias Johansson, Angus Roberts, Dan Chen, Yaoyong Li, Manon Delahaye-Sourdeix, Niraj Aswani, Mark A Greenwood, Simone Benhamou, Pagona Lagiou, Ivana Holcátová, Lorenzo Richiardi, Kristina Kjaerheim, Antonio Agudo, Xavier Castellsagué, Tatiana V Macfarlane, Luigi Barzan, Cristina Canova, Nalin S Thakker, David I Conway, Ariana Znaor, Claire M Healy, Wolfgang Ahrens, David Zaridze, Neonilia Szeszenia-Dabrowska, Jolanta Lissowska, Eleonóra Fabiánová, Ioan Nicolae Mates, Vladimir Bencko, Lenka Foretova, Vladimir Janout, Maria Paula Curado, Sergio Koifman, Ana Menezes, Victor Wünsch-Filho, Jose Eluf-Neto, Paolo Boffetta, Silvia Franceschi, Rolando Herrero, Leticia Fernandez Garrote, Renato Talamini, Stefania Boccia, Pilar Galan, Lars Vatten, Peter Thomson, Diana Zelenika, Mark Lathrop, Graham Byrnes, Hamish Cunningham, Paul Brennan, Jon Wakefield, James D McKay

Publikováno v: PLoS ONE, Vol 7, Iss 5, p e36888 (2012)

Genome-wide association studies (GWAS) require large sample sizes to obtain adequate statistical power, but it may be possible to increase the power by incorporating complementary data. In this study we investigated the feasibility of automatically r

Externí odkaz: https://doaj.org/article/c7c5fa4441ad4f948ef8ff3ff1c14f8c

Mannose-binding lectin deficiency is associated with myocardial infarction: the HUNT2 study in Norway.

Autor: Inga Thorsen Vengen, Hans O Madsen, Peter Garred, Carl Platou, Lars Vatten, Vibeke Videm

Publikováno v: PLoS ONE, Vol 7, Iss 7, p e42113 (2012)

OBJECTIVES: Mannose-binding lectin (MBL) and ficolins activate the complement cascade, which is involved in atherogenesis. Based on a pilot study, we hypothesized that functional polymorphisms in the MBL gene (MBL2) leading to dysfunctional protein a

Externí odkaz: https://doaj.org/article/d907a8618c8544c6846ec55c883fb2df

Correction: A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium.

Autor: James D. McKay, Therese Truong, Valerie Gaborieau, Amelie Chabrier, Shu-Chun Chuang, Graham Byrnes, David Zaridze, Oxana Shangina, Neonila Szeszenia-Dabrowska, Jolanta Lissowska, Peter Rudnai, Eleonora Fabianova, Alexandru Bucur, Vladimir Bencko, Ivana Holcatova, Vladimir Janout, Lenka Foretova, Pagona Lagiou, Dimitrios Trichopoulos, Simone Benhamou, Christine Bouchardy, Wolfgang Ahrens, Franco Merletti, Lorenzo Richiardi, Renato Talamini, Luigi Barzan, Kristina Kjaerheim, Gary J. Macfarlane, Tatiana V. Macfarlane, Lorenzo Simonato, Cristina Canova, Antonio Agudo, Xavier Castellsagué, Ray Lowry, David I. Conway, Patricia A. McKinney, Claire M. Healy, Mary E. Toner, Ariana Znaor, Maria Paula Curado, Sergio Koifman, Ana Menezes, Victor Wünsch-Filho, José Eluf Neto, Leticia Fernández Garrote, Stefania Boccia, Gabriella Cadoni, Dario Arzani, Andrew F. Olshan, Mark C. Weissler, William K. Funkhouser, Jingchun Luo, Jan Lubiński, Joanna Trubicka, Marcin Lener, Dorota Oszutowska, Stephen M. Schwartz, Chu Chen, Sherianne Fish, David R. Doody, Joshua E. Muscat, Philip Lazarus, Carla J. Gallagher, Shen-Chih Chang, Zuo-Feng Zhang, Qingyi Wei, Erich M. Sturgis, Li-E Wang, Silvia Franceschi, Rolando Herrero, Karl T. Kelsey, Michael D. McClean, Carmen J. Marsit, Heather H. Nelson, Marjorie Romkes, Shama Buch, Tomoko Nukui, Shilong Zhong, Martin Lacko, Johannes J. Manni, Wilbert H. M. Peters, Rayjean J. Hung, John McLaughlin, Lars Vatten, Inger Njølstad, Gary E. Goodman, John K. Field, Triantafillos Liloglou, Paolo Vineis, Francoise Clavel-Chapelon, Domenico Palli, Rosario Tumino, Vittorio Krogh, Salvatore Panico, Carlos A. González, J. Ramón Quirós, Carmen Martínez, Carmen Navarro, Eva Ardanaz, Nerea Larrañaga, Kay-Tee Khaw, Timothy Key, H. Bas Bueno-de-Mesquita, Petra H. M. Peeters, Antonia Trichopoulou, Jakob Linseisen, Heiner Boeing, Göran Hallmans, Kim Overvad, Anne Tjønneland, Merethe Kumle, Elio Riboli, Kristjan Välk, Tõnu Voodern, Andres Metspalu, Diana Zelenika, Anne Boland, Marc Delepine, Mario Foglio, Doris Lechner, Hélène Blanché, Ivo G. Gut, Pilar Galan, Simon Heath, Mia Hashibe, Richard B. Hayes, Paolo Boffetta, Mark Lathrop, Paul Brennan

Publikováno v: PLoS Genetics, Vol 7, Iss 4 (2011)

Externí odkaz: https://doaj.org/article/bd42d7968470441ea3a04a60c4ec4b2e