Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Lars U.W. Müller"'
Autor:
Wendy B. London, Chad E. Harris, Rutesh Vyas, Thorsten M. Schlaeger, Alex Devine, Kelly Strait, Axel Schambach, Lisa A. Moreau, David A. Williams, Elke Grassman, Alan D. D'Andrea, George Q. Daley, Kalindi Parmar, Michael D. Milsom, In-Hyun Park, Kristina Brumme, Lars U.W. Müller
Publikováno v:
Blood. 119:5449-5457
Fanconi anemia (FA) is a recessive syndrome characterized by progressive fatal BM failure and chromosomal instability. FA cells have inactivating mutations in a signaling pathway that is critical for maintaining genomic integrity and protecting cells
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2b61d0ef6b034dff991c50dbc29a9f5
https://doi.org/10.1182/blood-2012-02-408674
https://doi.org/10.1182/blood-2012-02-408674
Autor:
David A. Williams, Lars U.W. Müller
Publikováno v:
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis. 668:141-149
Fanconi anemia is a rare bone marrow failure and cancer predisposition syndrome. Childhood onset of aplastic anemia is one of the hallmarks of this condition. Supportive therapy in the form of blood products, androgens, and hematopoietic growth facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d30fcfe2bb6880152ce0e7dcaba49b
https://doi.org/10.1016/j.mrfmmm.2009.03.010
https://doi.org/10.1016/j.mrfmmm.2009.03.010
Publikováno v:
Molecular Therapy. 17(6):947-953
The concept of reversing the characteristics of differentiated tissues to pluripotency through reprogramming was introduced over 50 years ago in the first somatic cell nuclear transfer (SCNT) experiments. More recently, direct reprogramming of differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ff3d124512bdd147ef60722d879ffc9
Autor:
Emily K. Thomas, Yi Gu, Reuven J. Schore, Mi-Ok Kim, David A. Williams, Lars U.W. Müller, Jose A. Cancelas, Yi Zheng
Publikováno v:
Leukemia. 22:1803-1806
Acute myeloid leukemia (AML) is intrinsically prone to resistance to conventional chemotherapeutic agents. Here we explore the Rac family of small GTPases as novel biologic targets for AML treatment. The Rac subfamily of Rho guanosine triphosphatases
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711e6550d1f5954593177d32c2d06f64
https://doi.org/10.1038/leu.2008.196
https://doi.org/10.1038/leu.2008.196
Autor:
Lars U.W. Müller, Michael D. Milsom, Mi-Ok Kim, Todd Schuesler, David A. Williams, Axel Schambach
Publikováno v:
Molecular Therapy. 16:1154-1160
Fanconi anemia (FA) is a rare recessive syndrome, characterized by congenital anomalies, bone marrow failure, and predisposition to cancer. Two earlier clinical trials utilizing gamma-retroviral vectors for the transduction of autologous FA hematopoi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7e6c8d1f4cd7bceedee9d4222e9bb4f
https://doi.org/10.1038/mt.2008.67
https://doi.org/10.1038/mt.2008.67
Publikováno v:
Insertional Mutagenesis Strategies in Cancer Genetics ISBN: 9781441976550
From an early stage in the development of retroviral vectors for gene therapy applications, there has been a concern that recombinant vectors could elicit cellular transformation by altering expression of either cellular proto-oncogenes or tumor supp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::de73ba13534e157b2d0301232078c1e5
https://doi.org/10.1007/978-1-4419-7656-7_6
https://doi.org/10.1007/978-1-4419-7656-7_6
Autor:
Victoria Summey, Carlo M. Croce, David Z. Drew, Lars U.W. Müller, John C. Byrd, Ina Rattmann, Jose A. Cancelas, T. Moritz, Patrick Johnston, Yi Gu, David A. Williams, Abel Sanchez-Aguilera, David M. Lucas
Publikováno v:
Leukemia
RhoH is a hematopoietic-specific, GTPase-deficient member of the Rho GTPase family that functions as a regulator of thymocyte development and T-cell receptor signaling by facilitating localization of zeta-chain-associated protein kinase 70 (ZAP70) to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cda92db65748f137ac06518a75a08b8d
https://pubmed.ncbi.nlm.nih.gov/19847197
https://pubmed.ncbi.nlm.nih.gov/19847197
Publikováno v:
Blood. 110:194-194
Fanconi anemia (FA) is amenable to genetic correction of hematopoietic stem cells (HSCs). However, as demonstrated in previous clinical gene therapy trials, successful extension of murine studies into human therapies is limited by low numbers of targ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::91ab769fd87a2934817f714ee8c5a80d
https://doi.org/10.1182/blood.v110.11.194.194
https://doi.org/10.1182/blood.v110.11.194.194