Zobrazeno 1 - 10 of 35 pro vyhledávání: '"Lars Torup"'
1
Nalmefene for the management of alcohol dependence: review on its pharmacology, mechanism of action and meta-analysis on its clinical efficacy
Autor: Wim van den Brink, Per Sørensen, Lars Torup, Antoni Gual, Karl Mann, Robert M. Swift, Brendan M. Walker
Publikováno v: European neuropsychopharmacology. 26(12):1941-1949
Nalmefene, a mu- and delta-opioid receptor (MOR, DOR) antagonist and a partial kappa-opioid receptor (KOR) agonist, is approved in the European Union and other countries for the reduction of alcohol consumption in alcohol dependent patients with a hi
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12d783a48ed7f1fd9af33f980c5b2136
https://doi.org/10.1016/j.euroneuro.2016.10.008
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2
Extending the Treatment Options in Alcohol Dependence: A Randomized Controlled Study of As-Needed Nalmefene
Autor: Karl Mann, Bladström Anna, Lars Torup, Antoni Gual, Wim van den Brink
Publikováno v: Biological psychiatry, 73(8), 706-713. Elsevier USA
Background There is a large treatment gap in alcohol dependence, and current treatments are only moderately effective in preventing relapse. New treatment modalities, allowing for reduction of alcohol consumption as a treatment goal are needed. This
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f148d0e33361b60376802df06f4a3ac
https://doi.org/10.1016/j.biopsych.2012.10.020
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3
Efficacy of As-Needed Nalmefene in Alcohol-Dependent Patients with at Least a High Drinking Risk Level: Results from a Subgroup Analysis of Two Randomized Controlled 6-Month Studies
Autor: Wim van den Brink, Lars Torup, Antoni Gual, Henri-Jean Aubin, Bladström Anna, Karl Mann
Publikováno v: Alcohol and Alcoholism (Oxford, Oxfordshire)
Alcohol and alcoholism (Oxford, Oxfordshire), 48(5), 570-578. Oxford University Press
Aims: The aim of the study was to investigate the efficacy and safety of as-needed use of nalmefene 18 mg versus placebo in reducing alcohol consumption in patients who did not reduce their alcohol consumption after an initial assessment, i.e. the po
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60f59e6fbd6e684c54e112326d4c3eb1
https://doi.org/10.1093/alcalc/agt061
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6
Erythropoietin and carbamylated erythropoietin are neuroprotective following spinal cord hemisection in the rat
Autor: Sharon Averill, V.R. King, Adina T. Michael-Titus, D. Hewazy, Lars Torup, John V. Priestley
Publikováno v: European Journal of Neuroscience. 26:90-100
The cytokine erythropoietin (EPO) has been shown to be neuroprotective in a variety of models of central and peripheral nervous system injury. Derivatives of EPO that lack its erythropoietic effects have recently been developed, and the initial repor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::868b39ce4d16c42c98edee386cf2c815
https://doi.org/10.1111/j.1460-9568.2007.05635.x
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7
Reduced Functional Deficits, Neuroinflammation, and Secondary Tissue Damage after Treatment of Stroke by Nonerythropoietic Erythropoietin Derivatives
Autor: Michael Brines, Johan van Beek, Anna Kirstine Larsen, Anthony Cerami, Jens Gerwien, Marcel Leist, Lars Torup, Pia Villa, Søren Christensen, Pietro Ghezzi
Publikováno v: Journal of Cerebral Blood Flow & Metabolism. 27:552-563
Carbamylerythropoietin (CEPO) does not bind to the classical erythropoietin (EPO) receptor. Nevertheless, similarly to EPO, CEPO promotes neuroprotection on the histologic level in short-term stroke models. In the present study, we investigated wheth
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b371ac3b65553a84134d23813a70db6
https://doi.org/10.1038/sj.jcbfm.9600370
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8
Nonhematopoietic Erythropoietin Derivatives Prevent Motoneuron Degeneration In Vitro and In Vivo
Autor: Marina Marinovich, Paolo Bigini, Marcel Leist, Lars Torup, Emanuela Corsini, Johan van Beek, Anthony Cerami, Pietro Ghezzi, Tiziana Mennini, Michael Brines, Massimiliano De Paola, Manuela Mengozzi, Sara Barbera, Cristina Mastrotto, Barbara Viviani, Elena Fumagalli
Publikováno v: Molecular Medicine. 12:153-160
Chronic treatment with asialo erythropoietin (ASIALO-EPO) or carbamylated erythropoietin (CEPO) improved motor behavior and reduced motoneuron loss and astrocyte and microglia activation in the cervical spinal cord of wobbler mice, an animal model of
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022656b25cf3a1087aba7ba7242af007
https://doi.org/10.2119/2006-00045.mennini
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10
Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo
Autor: Jean Paul Wuerth, Marcel Leist, Simona Casagrande, Lars Torup, Marie Aavang Geist, Lone Helboe, Thomas N. Sager, Lars Østergaard Pedersen, Pietro Ghezzi, Michael Brines, Anthony Cerami, Zübeyde Erbayraktar, Thomas Coleman, Necati Gokmen, Osman Yilmaz, Serhat Erbayraktar, Giovanni Grasso, Pia Villa, Alessandra Sfacteria, Søren Christensen, Qiao wen Xie, Maddalena Fratelli, Jens Gerwein, Carla Cerami-Hand, Mads Kreilgaard
Publikováno v: Proceedings of the National Academy of Sciences. 100:6741-6746
Erythropoietin (EPO) is a tissue-protective cytokine preventing vascular spasm, apoptosis, and inflammatory responses. Although best known for its role in hematopoietic lineages, EPO also affects other tissues, including those of the nervous system.
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99450793cbcd29c356020c0155d9e98e
https://doi.org/10.1073/pnas.1031753100
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