Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Lars Sandberg"'
Autor:
Øystein Espeland Karlsen, Pål Borgen, Bjørn Bragnes, Wender Figved, Bjarne Grøgaard, Jonas Rydinge, Lars Sandberg, Finnur Snorrason, Helge Wangen, Eivind Witsøe, Marianne Westberg
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-9 (2020)
Abstract Background The evidence supporting rifampin combination therapy in prosthetic joint infections (PJI) is limited due to the lack of controlled studies. The aim of this study is to evaluate the effect of adding rifampin to conventional antimic
Externí odkaz:
https://doaj.org/article/0d000e3ed04a4eb99bca965aedaeae32
Autor:
Nadilly Bonagas, Nina M. S. Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna C. Green, Karl S. A. Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith E. Unterlass, Martin Haraldsson, Yasmin Andersson, Emma R. Scaletti, Christoffer Bengtsson, Cynthia B. J. Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene L. Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans E. Krokan, Per I. Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert J. Homan, Thomas Helleday
Publikováno v:
Nature Cancer
The folate metabolism enzyme MTHFD2 (methylenetetrahydrofolate dehydrogenase/cyclohydrolase) is consistently overexpressed in cancer but its roles are not fully characterized, and current candidate inhibitors have limited potency for clinical develop
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ebc803a4ce48681e11987b33fd0a94af
https://doi.org/10.1038/s43018-022-00331-y
https://doi.org/10.1038/s43018-022-00331-y
Autor:
Alanna C. Green, Petra Marttila, Nicole Kiweler, Christina Chalkiadaki, Elisée Wiita, Victoria Cookson, Antoine Lesur, Kim Eiden, François Bernardin, Karl S. A. Vallin, Sanjay Borhade, Maeve Long, Elahe Kamali Ghahe, Julio J. Jiménez-Alonso, Ann-Sofie Jemth, Olga Loseva, Oliver Mortusewicz, Marianne Meyers, Elodie Viry, Annika I. Johansson, Ondřej Hodek, Evert Homan, Nadilly Bonagas, Louise Ramos, Lars Sandberg, Morten Frödin, Etienne Moussay, Ana Slipicevic, Elisabeth Letellier, Jérôme Paggetti, Claus Storgaard Sørensen, Thomas Helleday, Martin Henriksson, Johannes Meiser
Cancer cells fuel their increased need for nucleotide supply by upregulating one-carbon (1C) metabolism, including the enzymes methylenetetrahydrofolate dehydrogenase-cyclohydrolase 1 and 2 (MTHFD1 and MTHFD2). TH9619 is a potent inhibitor of dehydro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cef4c9b031ee478e94f3df8742d2401f
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206656
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-206656
Autor:
Nadilly Bonagas, Nina Gustafsson, Martin Henriksson, Petra Marttila, Robert Gustafsson, Elisée Wiita, Sanjay Borhade, Alanna Green, Karl Vallin, Antonio Sarno, Richard Svensson, Camilla Göktürk, Therese Pham, Ann-Sofie Jemth, Olga Loseva, Victoria Cookson, Nicole Kiweler, Lars Sandberg, Azita Rasti, Judith Unterlass, Martin Haraldsson, Yasmin Andersson, Emma Scaletti, Christoffer Bengtsson, Cynthia Paulin, Kumar Sanjiv, Eldar Abdurakhmanov, Linda Pudelko, Ben Kunz, Matthieu Desroses, Petar Iliev, Katarina Färnegårdh, Andreas Krämer, Neeraj Garg, Maurice Michel, Sara Häggblad, Malin Jarvius, Christina Kalderén, Amanda Bögedahl Jensen, Ingrid Almlöf, Stella Karsten, Si Min Zhang, Maria Häggblad, Anders Eriksson, Jianping Liu, Björn Glinghammar, Natalia Nekhotiaeva, Fredrik Klingegård, Tobias Koolmeister, Ulf Martens, Sabin Llona-Minguez, Ruth Moulson, Helena Nordström, Vendela Parrow, Leif Dahllund, Birger Sjöberg, Irene Vargas, Duy Duc Vo, Johan Wannberg, Stefan Knapp, Hans Krokan, Per Arvidsson, Martin Scobie, Johannes Meiser, Pål Stenmark, Ulrika Warpman Berglund, Evert Homan, Thomas Helleday
Supplementary methods for the article "Pharmacological targeting of MTHFD2 suppresses acute myeloid leukemia by inducing thymidine depletion and replication stress".
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::032514cb5181fdda8fdfefd73848c5d0
https://doi.org/10.21203/rs.3.pex-1730/v1
https://doi.org/10.21203/rs.3.pex-1730/v1
Autor:
Gergana, Popova, Marcus J G W, Ladds, Lars, Johansson, Aljona, Saleh, Johanna, Larsson, Lars, Sandberg, Sara Häggblad, Sahlberg, Weixing, Qian, Hjalmar, Gullberg, Neeraj, Garg, Anna-Lena, Gustavsson, Martin, Haraldsson, David, Lane, Ulrika, Yngve, Sonia, Lain
Publikováno v:
Journal of medicinal chemistry. 63(8)
Human dihydroorotate dehydrogenase (DHODH), an enzyme in the de novo pyrimidine synthesis pathway, is a target for the treatment of rheumatoid arthritis and multiple sclerosis and is re-emerging as an attractive target for cancer therapy. Here we des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::730cacbe2fb4d2d6dbf3f019a39b96f0
https://pubmed.ncbi.nlm.nih.gov/32212728
https://pubmed.ncbi.nlm.nih.gov/32212728
Autor:
Bjarne Grøgaard, Helge Wangen, Øystein Espeland Karlsen, Bjørn Bragnes, Marianne Westberg, Wender Figved, Finnur Snorrason, Pål Borgen, Lars Sandberg, Jonas Rydinge, Eivind Witsøe
Publikováno v:
Journal of Orthopaedic Surgery and Research
Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-9 (2020)
Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-9 (2020)
Background The evidence supporting rifampin combination therapy in prosthetic joint infections (PJI) is limited due to the lack of controlled studies. The aim of this study is to evaluate the effect of adding rifampin to conventional antimicrobial th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18c9d65f229bb06f4d0942d7a9b6fa6e
https://doi.org/10.21203/rs.2.23809/v1
https://doi.org/10.21203/rs.2.23809/v1
Autor:
Michael Dabrowski, Olga Babich, Olof Larsson, Per-Eric Lund, Giannoula Klement, Zara A. Sands, Asa Malmberg, Lars Sandberg
Publikováno v:
Combinatorial Chemistry & High Throughput Screening. 15:713-720
Congenital Insensitivity to Pain (CIP) is a loss of function mutation resulting in a truncated NaV1.7 protein, suggesting a pivotal role in pain signaling and rendering it an important pharmaceutical target for multiple pain conditions. The structura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b29dafe662383c417635be1924f73151
https://doi.org/10.2174/138620712803519680
https://doi.org/10.2174/138620712803519680
Autor:
Tjerk Bueters, Gabor Csjernyik, Nilsson Linda I, Per-Eric Lund, Yevgeni Besidski, Istvan Macsari, Per I. Arvidsson, Ulrika Yngve, Sandra Oerther, Kristofer Åhlin, Lars Sandberg, Karin Hygge Blakeman, Lei Luo, Anders B. Eriksson, Elisabet Venyike
Publikováno v:
Journal of Medicinal Chemistry. 55:6866-6880
The voltage-gated sodium channel Na(V)1.7 is believed to be a critical mediator of pain sensation based on clinical genetic studies and pharmacological results. Clinical utility of nonselective sodium channel blockers is limited due to serious advers
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dd6fc194f3a561bd685e038690c2a01
https://doi.org/10.1021/jm300623u
https://doi.org/10.1021/jm300623u
Autor:
Tobias Ginman, Elisabet Venyike, Tjerk Bueters, Istvan Macsari, Lars Sandberg, Anders B. Eriksson, Yevgeni Besidski, Ylva Gravenfors, Per-Eric Lund, Johan Bylund, Per I. Arvidsson
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 21:3871-3876
Blocking of certain sodium channels is considered to be an attractive mechanism to treat chronic pain conditions. Phenyl isoxazole carbamate 1 was identified as a potent and selective Na(V)1.7 blocker. Structural analogues of 1, both carbamates, urea
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a598771737ba14364d0d2106e09e6409
https://doi.org/10.1016/j.bmcl.2011.05.041
https://doi.org/10.1016/j.bmcl.2011.05.041
Publikováno v:
The Journal of Physical Chemistry B. 106:7889-7897
Prediction of solvation free energies is an important subject in fundamental natural science but also important to the pharmaceutical and food industry. A popular modeling approach is to treat the solution by an implicit solvent model. The solute mol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8865559c6221a7076f3ca834a81b1ab6
https://doi.org/10.1021/jp020434b
https://doi.org/10.1021/jp020434b