Human P2X7 Receptor Causes Cycle Arrest in RPMI-8226 Myeloma Cells to Alter the Interaction with Osteoblasts and Osteoclasts

Autor: Ankita Agrawal, Lars S. Kruse, Annette J. Vangsted, Alison Gartland, Niklas R. Jørgensen

Publikováno v: Cells, Vol 9, Iss 11, p 2341 (2020)

Multiple myeloma is a malignant expansion of plasma cells and aggressively affects bone health. We show that P2X7 receptor altered myeloma growth, which affects primary bone cells in vitro. Expression on six human myeloma cell lines confirmed the het

Externí odkaz: https://doaj.org/article/9bb106d9f734455a8a12c418423de225

Human P2X7 Receptor Causes Cycle Arrest in RPMI-8226 Myeloma Cells to Alter the Interaction with Osteoblasts and Osteoclasts

Autor: Annette Juul Vangsted, Alison Gartland, Lars S Kruse, Niklas Rye Jørgensen, Ankita Agrawal

Publikováno v: Cells
Volume 9
Issue 11
Cells, Vol 9, Iss 2341, p 2341 (2020)
Agrawal, A, Kruse, L S, Vangsted, A J, Gartland, A & Jørgensen, N R 2020, ' Human P2X7 Receptor Causes Cycle Arrest in RPMI-8226 Myeloma Cells to Alter the Interaction with Osteoblasts and Osteoclasts ', Cells, vol. 9, no. 11 . https://doi.org/10.3390/cells9112341

Multiple myeloma is a malignant expansion of plasma cells and aggressively affects bone health. We show that P2X7 receptor altered myeloma growth, which affects primary bone cells in vitro. Expression on six human myeloma cell lines confirmed the het

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c83714d1f484e5513b4808d5a490dcc2

Heart ischaemia-reperfusion induces local up-regulation of vasoconstrictor endothelin ETBreceptors in rat coronary arteries downstream of occlusion

Autor: A F Pedersen, Majid Sheykhzade, Lars S Kruse, Rikke Larsen, Gry Freja Skovsted, Simon Trautner, Lars Edvinsson

Publikováno v: British Journal of Pharmacology. 171:2726-2738

Background and Purpose Endothelins act via two receptor subtypes, ETA and ETB. Under physiological conditions in coronary arteries, ETA receptors expressed in smooth muscle cells mediate vasoconstriction whereas ETB receptors mainly found in endothel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::630a785569cd6f791f8944d980f392be
https://doi.org/10.1111/bph.12606

PDE9A, PDE10A, and PDE11A expression in rat trigeminovascular pain signalling system

Autor: Steen Gammeltoft, Christina Kruuse, Maiken Tibæk, Jes Olesen, Lars S Kruse, Morten Møller

Publikováno v: Brain Research. 1281:25-34

Activation of the trigeminovascular pain signalling system, including cerebral arteries, meninges, trigeminal ganglion, and brain stem, is involved in migraine. Furthermore, stimulation of cyclic nucleotide (cAMP and cGMP) production as well as inhib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38688b7ff6eadc10fba9492470e747ae
https://doi.org/10.1016/j.brainres.2009.05.012

Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ETB receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat

Autor: Lars S Kruse, Lars Edvinsson, Karin Warfvinge, Gry Freja Skovsted, Anne-Sofie Grell, Lukas Adrian Berchtold

Publikováno v: Skovsted, G F, Kruse, L S, Berchtold, L A, Grell, A-S, Warfvinge, K & Edvinsson, L 2017, ' Myocardial ischemia-reperfusion enhances transcriptional expression of endothelin-1 and vasoconstrictor ET B receptors via the protein kinase MEK-ERK1/2 signaling pathway in rat ', PLOS ONE, vol. 12, no. 3, e0174119 . https://doi.org/10.1371/journal.pone.0174119
PLoS ONE, Vol 12, Iss 3, p e0174119 (2017)
PLoS ONE

Background: Coronary artery remodelling and vasospasm is a complication of acute myocardial ischemia and reperfusion. The underlying mechanisms are complex, but the vasoconstrictor peptide endothelin-1 is suggested to have an important role. This stu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb222d8db220bb4dacd7f86be8bb2e60
https://doi.org/10.1371/journal.pone.0174119