Ablation of DNA-methyltransferase 3A in skeletal muscle does not affect energy metabolism or exercise capacity.

Autor: Lewin Small, Lars R Ingerslev, Eleonora Manitta, Rhianna C Laker, Ann N Hansen, Brendan Deeney, Alain Carrié, Philippe Couvert, Romain Barrès

Publikováno v: PLoS Genetics, Vol 17, Iss 1, p e1009325 (2021)

In response to physical exercise and diet, skeletal muscle adapts to energetic demands through large transcriptional changes. This remodelling is associated with changes in skeletal muscle DNA methylation which may participate in the metabolic adapta

Externí odkaz: https://doaj.org/article/b980783ce524444ea61f6aac736af9c6

T cell epigenetic remodeling and accelerated epigenetic aging are linked to long-term immune alterations in childhood cancer survivors

Autor: Sara Daniel, Vibe Nylander, Lars R. Ingerslev, Ling Zhong, Odile Fabre, Briana Clifford, Karen Johnston, Richard J. Cohn, Romain Barres, David Simar

Publikováno v: Clinical Epigenetics, Vol 10, Iss 1, Pp 1-13 (2018)

Abstract Background Cancer treatments have substantially improved childhood cancer survival but are accompanied by long-term complications, notably chronic inflammatory diseases. We hypothesize that cancer treatments could lead to long-term epigeneti

Externí odkaz: https://doaj.org/article/edb0733ec8ae4762b4ded01814dd0678

High-fat diet reprograms the epigenome of rat spermatozoa and transgenerationally affects metabolism of the offspring

Autor: Thais de Castro Barbosa, Lars R. Ingerslev, Petter S. Alm, Soetkin Versteyhe, Julie Massart, Morten Rasmussen, Ida Donkin, Rasmus Sjögren, Jonathan M. Mudry, Laurène Vetterli, Shashank Gupta, Anna Krook, Juleen R. Zierath, Romain Barrès

Publikováno v: Molecular Metabolism, Vol 5, Iss 3, Pp 184-197 (2016)

Objectives: Chronic and high consumption of fat constitutes an environmental stress that leads to metabolic diseases. We hypothesized that high-fat diet (HFD) transgenerationally remodels the epigenome of spermatozoa and metabolism of the offspring.

Externí odkaz: https://doaj.org/article/53c3d652fd614af285600d41d39b1dd2

NAMPT-dependent NAD + biosynthesis controls circadian metabolism in a tissue-specific manner

Autor: Astrid L. Basse, Karen N. Nielsen, Iuliia Karavaeva, Lars R. Ingerslev, Tao Ma, Jesper F. Havelund, Thomas S. Nielsen, Mikkel Frost, Julia Peics, Emilie Dalbram, Morten Dall, Juleen R. Zierath, Romain Barrès, Nils J. Færgeman, Jonas T. Treebak, Zachary Gerhart-Hines

Publikováno v: Basse, A L, Nielsen, K N, Karavaeva, I, Ingerslev, L R, Ma, T, Havelund, J F, Nielsen, T S, Frost, M, Peics, J, Dalbram, E, Dall, M, Zierath, J R, Barrès, R, Færgeman, N J, Treebak, J T & Gerhart-Hines, Z 2023, ' NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 14, e2220102120 . https://doi.org/10.1073/pnas.2220102120

Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating input from the hypothalamic master clock and intracellular metabolic signals. One such key metabolic signal is the cellular concentration of NAD + , which os

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c273dfdf97b93fab97fdc623e5cb7f38
https://doi.org/10.1073/pnas.2220102120

Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP-1 analogue treatment:a randomized controlled trial

Autor: Emil Andersen, Christian R Juhl, Emma T Kjøller, Julie R Lundgren, Charlotte Janus, Yasmin Dehestani, Marte Saupstad, Lars R Ingerslev, Olivia M Duun, Simon B K Jensen, Jens J Holst, Bente M Stallknecht, Sten Madsbad, Signe S Torekov, Romain Barrès

Publikováno v: Andersen, E, Juhl, C R, Kjøller, E T, Lundgren, J R, Janus, C, Dehestani, Y, Saupstad, M, Ingerslev, L R, Duun, O M, Jensen, S B K, Holst, J J, Stallknecht, B M, Madsbad, S, Torekov, S S & Barrès, R 2022, ' Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP-1 analogue treatment : a randomized controlled trial ', Human Reproduction, vol. 37, no. 7, pp. 1414–1422 . https://doi.org/10.1093/humrep/deac096

STUDY QUESTION Does diet-induced weight loss improve semen parameters, and are these possible improvements maintained with sustained weight loss? SUMMARY ANSWER An 8-week low-calorie diet-induced weight loss was associated with improved sperm concent

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0eef71514d6abf7ed23cae393b3286
https://curis.ku.dk/portal/da/publications/sperm-count-is-increased-by-dietinduced-weight-loss-and-maintained-by-exercise-or-glp1-analogue-treatment(8e714f37-9727-44b0-a094-31c99f02e037).html