Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Lars R Ingerslev"'
Autor:
Lewin Small, Lars R Ingerslev, Eleonora Manitta, Rhianna C Laker, Ann N Hansen, Brendan Deeney, Alain Carrié, Philippe Couvert, Romain Barrès
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009325 (2021)
In response to physical exercise and diet, skeletal muscle adapts to energetic demands through large transcriptional changes. This remodelling is associated with changes in skeletal muscle DNA methylation which may participate in the metabolic adapta
Externí odkaz:
https://doaj.org/article/b980783ce524444ea61f6aac736af9c6
Autor:
Kathryn M. Farris, Alistair M. Senior, Débora R. Sobreira, Robert M. Mitchell, Zachary T. Weber, Lars R. Ingerslev, Romain Barrès, Stephen J. Simpson, Angela J. Crean, Marcelo A. Nobrega
Publikováno v:
Communications Biology, Vol 7, Iss 1, Pp 1-13 (2024)
Abstract Diet is a key lifestyle component that influences metabolic health through several factors, including total energy intake and macronutrient composition. While the impact of caloric intake on gene expression and physiological phenomena in var
Externí odkaz:
https://doaj.org/article/7dbebc4349a940b19cdb5cc883a0451e
Autor:
Lars R. Ingerslev, Ida Donkin, Odile Fabre, Soetkin Versteyhe, Mie Mechta, Pattarawan Pattamaprapanont, Brynjulf Mortensen, Nikolaj Thure Krarup, Romain Barrès
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-11 (2018)
Abstract Remodeling of the sperm epigenome by lifestyle factors before conception could account for altered metabolism in the next generation offspring. Here, we hypothesized that endurance training changes the epigenome of human spermatozoa. Using s
Externí odkaz:
https://doaj.org/article/04d3e7db839c4df1b84cb57f45f3af4a
Autor:
Astrid L. Basse, Karen N. Nielsen, Iuliia Karavaeva, Lars R. Ingerslev, Tao Ma, Jesper F. Havelund, Thomas S. Nielsen, Mikkel Frost, Julia Peics, Emilie Dalbram, Morten Dall, Juleen R. Zierath, Romain Barrès, Nils J. Færgeman, Jonas T. Treebak, Zachary Gerhart-Hines
Publikováno v:
Basse, A L, Nielsen, K N, Karavaeva, I, Ingerslev, L R, Ma, T, Havelund, J F, Nielsen, T S, Frost, M, Peics, J, Dalbram, E, Dall, M, Zierath, J R, Barrès, R, Færgeman, N J, Treebak, J T & Gerhart-Hines, Z 2023, ' NAMPT-dependent NAD+ biosynthesis controls circadian metabolism in a tissue-specific manner ', Proceedings of the National Academy of Sciences of the United States of America, vol. 120, no. 14, e2220102120 . https://doi.org/10.1073/pnas.2220102120
Molecular clocks in the periphery coordinate tissue-specific daily biorhythms by integrating input from the hypothalamic master clock and intracellular metabolic signals. One such key metabolic signal is the cellular concentration of NAD + , which os
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c273dfdf97b93fab97fdc623e5cb7f38
https://doi.org/10.1073/pnas.2220102120
https://doi.org/10.1073/pnas.2220102120
Autor:
Christine Hjorth Andreassen, Mette Lorenzen, John E. Nielsen, Sam Kafai Yahyavi, Birgitte Grønkær Toft, Lars R. Ingerslev, Christoffer Clemmensen, Lene Juel Rasmussen, Carsten Bokemeyer, Anders Juul, Anne Jørgensen, Martin Blomberg Jensen
Publikováno v:
Br J Cancer
BACKGROUND: Testicular germ cell tumours (TGCTs) have a high sensitivity to chemotherapy and a high cure rate, although with serious adverse effects. In the search for tumour suppressive drugs, the RANKL inhibitor Denosumab, used to treat osteoporosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68c130ee928c68a233d469761dd4e640
https://doi.org/10.1038/s41416-022-01810-w
https://doi.org/10.1038/s41416-022-01810-w
Autor:
Emil Andersen, Christian R Juhl, Emma T Kjøller, Julie R Lundgren, Charlotte Janus, Yasmin Dehestani, Marte Saupstad, Lars R Ingerslev, Olivia M Duun, Simon B K Jensen, Jens J Holst, Bente M Stallknecht, Sten Madsbad, Signe S Torekov, Romain Barrès
Publikováno v:
Andersen, E, Juhl, C R, Kjøller, E T, Lundgren, J R, Janus, C, Dehestani, Y, Saupstad, M, Ingerslev, L R, Duun, O M, Jensen, S B K, Holst, J J, Stallknecht, B M, Madsbad, S, Torekov, S S & Barrès, R 2022, ' Sperm count is increased by diet-induced weight loss and maintained by exercise or GLP-1 analogue treatment : a randomized controlled trial ', Human Reproduction, vol. 37, no. 7, pp. 1414–1422 . https://doi.org/10.1093/humrep/deac096
STUDY QUESTION Does diet-induced weight loss improve semen parameters, and are these possible improvements maintained with sustained weight loss? SUMMARY ANSWER An 8-week low-calorie diet-induced weight loss was associated with improved sperm concent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b0eef71514d6abf7ed23cae393b3286
https://curis.ku.dk/portal/da/publications/sperm-count-is-increased-by-dietinduced-weight-loss-and-maintained-by-exercise-or-glp1-analogue-treatment(8e714f37-9727-44b0-a094-31c99f02e037).html
https://curis.ku.dk/portal/da/publications/sperm-count-is-increased-by-dietinduced-weight-loss-and-maintained-by-exercise-or-glp1-analogue-treatment(8e714f37-9727-44b0-a094-31c99f02e037).html
Autor:
Farideh Moharrek, Lars R Ingerslev, Ali Altıntaş, Leonidas Lundell, Ann N Hansen, Lewin Small, Christopher T Workman, Romain Barrès
Publikováno v:
Moharrek, F, Ingerslev, L R, Altıntaş, A, Lundell, L, Hansen, A N, Small, L, Workman, C T & Barrès, R 2022, ' Comparative analysis of sperm DNA methylation supports evolutionary acquired epigenetic plasticity for organ speciation ', Epigenomics, vol. 14, no. 21, pp. 1305-1324 . https://doi.org/10.2217/epi-2022-0168
Aim: To perform a comparative epigenomic analysis of DNA methylation in spermatozoa from humans, mice, rats and mini-pigs. Materials & methods: Genome-wide DNA methylation analysis was used to compare the methylation profiles of orthologous CpG sites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::04a6d85f8ab63aafd5cf5d387f289aa2
https://orbit.dtu.dk/en/publications/00d6c99e-2e5f-4052-a57e-3cece390d4fd
https://orbit.dtu.dk/en/publications/00d6c99e-2e5f-4052-a57e-3cece390d4fd
Autor:
Leonidas S. Lundell, Wolf Reik, Romain Barrès, Emil Andersen, Stephen J. Clark, Lars R. Ingerslev
Epigenetic marks in gametes modulate developmental programming after fertilization. Spermatozoa from obese men exhibit distinct epigenetic signatures compared to lean men, however, whether epigenetic differences are concentrated in a sub-population o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c5877114ab314fb84e78e9b0a58087f
https://doi.org/10.1101/2021.07.09.451752
https://doi.org/10.1101/2021.07.09.451752
Autor:
Brendan Deeney, Lewin Small, Rhianna C. Laker, Lars R. Ingerslev, Romain Barrès, Alain Carrié, Philippe Couvert, Ann Normann Hansen, Eleonora Manitta
Publikováno v:
PLoS Genetics, Vol 17, Iss 1, p e1009325 (2021)
PLoS Genetics
PLoS Genetics, 2021, 17 (1), pp.e1009325. ⟨10.1371/journal.pgen.1009325⟩
PLoS Genetics, Public Library of Science, 2021, 17 (1), pp.e1009325. ⟨10.1371/journal.pgen.1009325⟩
Small, L, Ingerslev, L R, Manitta, E, Laker, R C, Hansen, A N, Deeney, B, Carrie, A, Couvert, P & Barres, R 2021, ' Ablation of DNA-methyltransferase 3A in skeletal muscle does not affect energy metabolism or exercise capacity ', PLOS Genetics, vol. 17, no. 1, 1009325 . https://doi.org/10.1371/journal.pgen.1009325
PLoS Genetics
PLoS Genetics, 2021, 17 (1), pp.e1009325. ⟨10.1371/journal.pgen.1009325⟩
PLoS Genetics, Public Library of Science, 2021, 17 (1), pp.e1009325. ⟨10.1371/journal.pgen.1009325⟩
Small, L, Ingerslev, L R, Manitta, E, Laker, R C, Hansen, A N, Deeney, B, Carrie, A, Couvert, P & Barres, R 2021, ' Ablation of DNA-methyltransferase 3A in skeletal muscle does not affect energy metabolism or exercise capacity ', PLOS Genetics, vol. 17, no. 1, 1009325 . https://doi.org/10.1371/journal.pgen.1009325
In response to physical exercise and diet, skeletal muscle adapts to energetic demands through large transcriptional changes. This remodelling is associated with changes in skeletal muscle DNA methylation which may participate in the metabolic adapta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c37cb40f335d44ea0ef66ae73ff86b0
https://doaj.org/article/b980783ce524444ea61f6aac736af9c6
https://doaj.org/article/b980783ce524444ea61f6aac736af9c6
Autor:
Romain Barrès, Soetkin Versteyhe, Ida Donkin, Svenja Hansson, Kristine Williams, Lars R. Ingerslev, Tuomas O. Kilpeläinen, Germán D. Carrasquilla, Nicolas J. Pillon, Mette Yde Hochreuter, Juleen R. Zierath
Publikováno v:
Williams, K, Carrasquilla, G D, Ingerslev, L R, Hochreuter, M Y, Hansson, S, Pillon, N J, Donkin, I, Versteyhe, S, Zierath, J R, Kilpeläinen, T O & Barrès, R 2021, ' Epigenetic rewiring of skeletal muscle enhancers after exercise training supports a role in the whole-body function and human health ', Molecular Metabolism, vol. 53, 101290 . https://doi.org/10.1016/j.molmet.2021.101290
Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101290-(2021)
Molecular Metabolism
Molecular Metabolism, Vol 53, Iss, Pp 101290-(2021)
Objectives Regular physical exercise improves health by reducing the risk of a plethora of chronic disorders. We hypothesized that endurance exercise training remodels the activity of gene enhancers in skeletal muscle and that this remodeling contrib
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c47b9bae53632fcb68361a7fbab983ca
https://curis.ku.dk/portal/da/publications/epigenetic-rewiring-of-skeletal-muscle-enhancers-after-exercise-training-supports-a-role-in-the-wholebody-function-and-human-health(83d357b6-a538-4e27-8083-d4d0d6e14a89).html
https://curis.ku.dk/portal/da/publications/epigenetic-rewiring-of-skeletal-muscle-enhancers-after-exercise-training-supports-a-role-in-the-wholebody-function-and-human-health(83d357b6-a538-4e27-8083-d4d0d6e14a89).html