Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Lars Prade"'
Autor:
Christoph Boss, Reto Brun, Walter Fischli, Christoph Binkert, Solange Meyer, Lars Prade, Luke Harris, Lionel Coppex, Corinna Grisostomi, Olivier Corminboeuf, Jean-Marc Bourgeois, Rocco Furnari, Sylvia Richard-Bildstein, Thomas Weller
Publikováno v:
CHIMIA, Vol 58, Iss 9 (2004)
Malaria is a very serious infectious disease affecting over two billion people worldwide. Currently available antimalarial drugs are losing effectiveness due to the emergence and the spread of resistant parasite strains. In order to regain control ov
Externí odkaz:
https://doaj.org/article/fd58db8601ee4bc29579ec1db0929e93
Autor:
Markus Gude, Georg Rueedi, Thomas Pfeifer, Christian Hubschwerlen, Daniel Ritz, Thierry Kimmerlin, L. Jacob, A.-C. Blumstein, Daniel Bur, Alain Chambovey, Lars Prade, Peter Seiler, Philippe Panchaud, Eric A. Ertel, Thierry Bruyère
Publikováno v:
Journal of Medicinal Chemistry. 60:3755-3775
Our strategy to combat resistant bacteria consisted of targeting the GyrB/ParE ATP-binding sites located on bacterial DNA gyrase and topoisomerase IV and not utilized by marketed antibiotics. Screening around the minimal ethyl urea binding motif led
Autor:
Lars Prade, Panja Strickner, Corinna Grisostomi, Beat Steiner, Walter Fischli, Alexander Treiber, Daniel Bur, Olivier Bezencon, Ľuboš Remeň, Patrick Hess, Sylvia Richard-Bildstein, Olivier Corminboeuf
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6291-6296
The optimization of the 4-position of recently described new 3,4-disubstituted piperidine-based renin inhibitors is reported herein. The synthesis and characterization of compounds leading to the discovery of 11 (ACT-178882, MK-1597), a renin inhibit
Autor:
Corinna Grisostomi, Beat Steiner, Walter Fischli, Patrick Hess, Sylvia Richard-Bildstein, Olivier Corminboeuf, Panja Strickner, Lars Prade, Olivier Bezencon, Lubos Remen, Alexander Treiber, Daniel Bur
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:6286-6290
The discovery of a new series of piperidine-based renin inhibitors is described herein. SAR optimization upon the P3 renin sub-pocket is described, leading to the discovery of 9 and 41, two bioavailable renin inhibitors orally active at low doses in
Autor:
Massimo Frigerio, Matteo Zanda, Cristina Pesenti, Fiorenza Viani, Solange Meyer, Lars Prade, Andrew Jones, Christoph Binkert
Publikováno v:
ChemBioChem
7 (2006): 181–186. doi:10.1002/cbic.200500180
info:cnr-pdr/source/autori:Binkert C., Frigerio M., Jones A., Meyer S., Pesenti C., Prade L., Viani F., Zanda M./titolo:Replacement of isobutyl by trifluoromethyl in pepstatin A selectively affects inhibition of aspartic proteinases/doi:10.1002%2Fcbic.200500180/rivista:ChemBioChem (Print)/anno:2006/pagina_da:181/pagina_a:186/intervallo_pagine:181–186/volume:7
7 (2006): 181–186. doi:10.1002/cbic.200500180
info:cnr-pdr/source/autori:Binkert C., Frigerio M., Jones A., Meyer S., Pesenti C., Prade L., Viani F., Zanda M./titolo:Replacement of isobutyl by trifluoromethyl in pepstatin A selectively affects inhibition of aspartic proteinases/doi:10.1002%2Fcbic.200500180/rivista:ChemBioChem (Print)/anno:2006/pagina_da:181/pagina_a:186/intervallo_pagine:181–186/volume:7
Two bis-trifluoromethyl pepstatin A analogues, carboxylic acid 1 and its methyl ester 2, have been synthesised in order to probe the properties and size of the trifluoromethyl (Tfm) group and compare it to the "bigger" isobutyl that is present in pep
Autor:
Sylvia Richard-Bildstein, Christoph Boss, Daniel Bur, Christoph Binkert, Solange Meyer, Lars Prade, Andrew F. Jones
Publikováno v:
Journal of Biological Chemistry. 280:23837-23843
The malaria parasite Plasmodium falciparum degrades host cell hemoglobin inside an acidic food vacuole during the blood stage of the infectious cycle. A number of aspartic proteinases called plasmepsins (PMs) have been identified to play important ro
Publikováno v:
Journal of Molecular Biology. 296:569-577
Catalyzing the first step in the de novo synthesis of adenylmonophosphate, adenylosuccinate synthetase (AdSS) is a known target for herbicides and antibiotics. We have purified and crystallized recombinant AdSS from Arabidopsis thaliana and Tritium a
Autor:
Keigo Gohda, Jean-Yves Sancéau, Sandra W. Cowan-Jacob, Philippe Chemla, Lars Prade, Raymonde Fonne-Pfister, Stephen Hanessian, Pu-Ping Lu
Publikováno v:
Angewandte Chemie. 111:3353-3356
Autor:
Lars Prade, Raymonde Fonne-Pfister, Stephen Hanessian, Keigo Gohda, Jean-Yves Sancéau, Philippe Chemla, Pu-Ping Lu, Sandra W. Cowan-Jacob
Publikováno v:
Angewandte Chemie International Edition. 38:3159-3162
Two relatively weak herbicides, hydantocidin phosphate and hadacidin were linked by a C3 chain to afford a potent inhibitor (the 2S hybrid is shown) of the enzyme adenylosuccinate synthetase. The crystal structures of the bisubstrate–enzyme complex
Publikováno v:
Pesticide Science. 55:248-252