Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Lars Piepkorn"'
Autor:
Martin Meschkat, Anna M. Steyer, Marie-Theres Weil, Kathrin Kusch, Olaf Jahn, Lars Piepkorn, Paola Agüi-Gonzalez, Nhu Thi Ngoc Phan, Torben Ruhwedel, Boguslawa Sadowski, Silvio O. Rizzoli, Hauke B. Werner, Hannelore Ehrenreich, Klaus-Armin Nave, Wiebke Möbius
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Myelin is formed of proteins of long half-lives. The mechanisms of renewal of such a stable structure are unclear. Here, the authors show that myelin integrity requires continuous myelin synthesis at the inner tongue, contributing to the maintenance
Externí odkaz:
https://doaj.org/article/287e7feee643483fbef3a7725df08a2f
Autor:
Vasiliki-Ilya Gargareta, Josefine Reuschenbach, Sophie B Siems, Ting Sun, Lars Piepkorn, Carolina Mangana, Erik Späte, Sandra Goebbels, Inge Huitinga, Wiebke Möbius, Klaus-Armin Nave, Olaf Jahn, Hauke B Werner
Publikováno v:
eLife, Vol 11 (2022)
Human myelin disorders are commonly studied in mouse models. Since both clades evolutionarily diverged approximately 85 million years ago, it is critical to know to what extent the myelin protein composition has remained similar. Here, we use quantit
Externí odkaz:
https://doaj.org/article/4e5b92e78c254760b002c60c7dec1836
Autor:
Madhurima Chatterjee, Selcuk Özdemir, Marcel Kunadt, Marleen Koel‐Simmelink, Walter Boiten, Lars Piepkorn, Thang V. Pham, Davide Chiasserini, Sander R. Piersma, Jaco C. Knol, Wiebke Möbius, Brit Mollenhauer, Wiesje M. van der Flier, Connie R. Jimenez, Charlotte E. Teunissen, Olaf Jahn, Anja Schneider
Publikováno v:
Chatterjee, M, Özdemir, S, Kunadt, M, Koel-Simmelink, M, Boiten, W, Piepkorn, L, Pham, T V, Chiasserini, D, Piersma, S R, Knol, J C, Möbius, W, Mollenhauer, B, van der Flier, W M, Jimenez, C R, Teunissen, C E, Jahn, O & Schneider, A 2023, ' C1q is increased in cerebrospinal fluid-derived extracellular vesicles in Alzheimer's disease : A multi-cohort proteomics and immuno-assay validation study ', Alzheimer's and Dementia . https://doi.org/10.1002/alz.13066
Alzheimer's & Dementia
Alzheimer's and Dementia. Elsevier
Alzheimer's and dementia Advance online publication, n/a (2023). doi:10.1002/alz.13066
Alzheimer's & Dementia
Alzheimer's and Dementia. Elsevier
Alzheimer's and dementia Advance online publication, n/a (2023). doi:10.1002/alz.13066
Introduction:Extracellular vesicles (EVs) may propagate and modulate Alzheimer's disease (AD) pathology. We aimed to comprehensively characterize the proteome of cerebrospinal fluid (CSF) EVs to identify proteins and pathways altered in AD.Methods:CS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cae5e241dbed16b29fc7c77170668606
https://hdl.handle.net/11391/1554627
https://hdl.handle.net/11391/1554627
Autor:
Tim Düking, Lena Spieth, Stefan A. Berghoff, Lars Piepkorn, Annika M. Schmidke, Miso Mitkovski, Nirmal Kannaiyan, Leon Hosang, Patricia Scholz, Ali H. Shaib, Lennart V. Schneider, Dörte Hesse, Torben Ruhwedel, Ting Sun, Lisa Linhoff, Andrea Trevisiol, Susanne Köhler, Adrian Marti Pastor, Thomas Misgeld, Michael Sereda, Imam Hassouna, Moritz J. Rossner, Francesca Odoardi, Till Ischebeck, Livia de Hoz, Johannes Hirrlinger, Olaf Jahn, Gesine Saher
Publikováno v:
Science Advances
Science advances 8(37), eabo7639 (2022). doi:10.1126/sciadv.abo7639
Science advances 8(37), eabo7639 (2022). doi:10.1126/sciadv.abo7639
To maintain homeostasis, the body, including the brain, reprograms its metabolism in response to altered nutrition or disease. However, the consequences of these challenges for the energy metabolism of the different brain cell types remain unknown. H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::429b042988b73b13bc8c23baed1b8d83
https://hdl.handle.net/21.11116/0000-000B-3BC4-621.11116/0000-000B-3BC6-4
https://hdl.handle.net/21.11116/0000-000B-3BC4-621.11116/0000-000B-3BC6-4
Autor:
Ting Sun, Sophie B Siems, Josefine Reuschenbach, Vasiliki-Ilya Gargareta, Lars Piepkorn, Carolina Mangana, Erik Späte, Sandra Goebbels, Inge Huitinga, Wiebke Möbius, Klaus-Armin Nave, Olaf Jahn, Hauke B Werner
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::23b59f1cfabab0de4dc75eb4985f8bce
https://doi.org/10.7554/elife.77019.sa2
https://doi.org/10.7554/elife.77019.sa2
Autor:
Rachel Straussberg, Marta Rosário, Guntram Borck, Victor Tarabykin, Olaf Jahn, Stephen Horan, A Ioana Weber, Rüstem Yilmaz, Ekrem Dere, Alina Smorodchenko, Hong Jun Rhee, Jeong-Seop Rhee, Susanne Mueller, Katrin I. Willig, Philipp Boehm-Sturm, Manuela Schwark, Mateusz C. Ambrozkiewicz, Sami Zaqout, Ekaterina Borisova, Theres Schaub, Bekir Altas, Silvia Ripamonti, Hiroshi Kawabe, Lars Piepkorn
Publikováno v:
Molecular Psychiatry. 26:1980-1995
Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly, and characteristic dysmorphisms. Biallelic mutations of UBE3B, encoding for a ubiquitin l
Autor:
Hauke B. Werner, Hannelore Ehrenreich, Paola Agüi-Gonzalez, Olaf Jahn, Torben Ruhwedel, Lars Piepkorn, Anna M. Steyer, Klaus-Armin Nave, Silvio O. Rizzoli, Boguslawa Sadowski, Kathrin Kusch, Martin Meschkat, Nhu Thi Ngoc Phan, Wiebke Möbius, Marie-Theres Weil
SummaryMyelin, the electrically insulating axonal sheath, is composed of lipids and proteins with exceptionally long lifetime. This raises the question how myelin function is affected by myelin turnover. We have studied the integrity of myelinated tr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fce24448ad777f676e696ad6f9529d75
https://doi.org/10.1101/2020.09.02.279612
https://doi.org/10.1101/2020.09.02.279612
Autor:
Hannelore Ehrenreich, Stephen Horan, Guntram Borck, Rüstem Yilmaz, Victor Tarabykin, Olaf Jahn, Ekrem Dere, Ekaterina Borisova, Silvia Ripamonti, Hiroshi Kawabe, Manuela Schwark, Marta Rosário, Mateusz C. Ambrozkiewicz, Katrin I. Willig, Jeong-Seop Rhee, Lars Piepkorn, Theres Schaub, Bekir Altas
Kaufman oculocerebrofacial syndrome (KOS) is a severe autosomal recessive disorder characterized by intellectual disability, developmental delays, microcephaly and characteristic dysmorphisms. Biallelic mutations ofUBE3B, encoding for a ubiquitin lig
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7b4a309974d0ff6ce9870a6a382df2b
Autor:
Ekaterina Borisova, Tamara Rabe, Xin Zhang, Lars Piepkorn, Mateusz C. Ambrozkiewicz, Theres Schaub, Silvia Ripamonti, Hiroshi Kawabe, Bekir Altas, Paraskevi Bessa, Marta Rosário, Mika Kishimoto-Suga, Victor Tarabykin, Olaf Jahn, Haruhiko Akiyama, Alexandra Rusanova, Kei Hori, Manuela Schwark, Tatsuya Kobayashi, Mikio Hoshino, Andrea Salazar-Lázaro
Publikováno v:
Neuron
Summary The establishment of axon-dendrite polarity is fundamental for radial migration of neurons during cortex development of mammals. We demonstrate that the E3 ubiquitin ligases WW-Containing Proteins 1 and 2 (Wwp1 and Wwp2) are indispensable for
Publikováno v:
Aging Cell
Summary A proper equilibrium of post‐translational protein modifications is essential for normal cell physiology, and alteration in these processes is key in neurodegenerative disorders such as Alzheimer's disease. Recently, for instance, alteratio