Beta-hydroxyphosphonate ribonucleoside analogues derived from 4-substituted-1,2,3-triazoles as IMP/GMP mimics: synthesis and biological evaluation

Autor: Tai Nguyen Van, Audrey Hospital, Corinne Lionne, Lars P. Jordheim, Charles Dumontet, Christian Périgaud, Laurent Chaloin, Suzanne Peyrottes

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 12, Iss 1, Pp 1476-1486 (2016)

A series of seventeen β-hydroxyphosphonate ribonucleoside analogues containing 4-substituted-1,2,3-triazoles was synthesized and fully characterized. Such compounds were designed as potential inhibitors of the cytosolic 5’-nucleotidase II (cN-II),

Externí odkaz: https://doaj.org/article/cc5144b58e564e1c8795aa0043ab1863

Correction: ADP Ribosylation Factor Like 2 (Arl2) Regulates Breast Tumor Aggressivity in Immunodeficient Mice.

Autor: Anne Beghin, Stéphane Belin, Rouba Hage-Sleiman, Stéphanie Brunet Manquat, Sophie Goddard, Eric Tabone, Lars P. Jordheim, Isabelle Treilleux, Marie-France Poupon, Jean-Jacques Diaz, Charles Dumontet

Publikováno v: PLoS ONE, Vol 4, Iss 11 (2009)

Externí odkaz: https://doaj.org/article/4247d54c24f64b5a952c7fe415c0e997

Enriched PUFA environment of Leishmania infantum promastigotes promotes the accumulation of lipid mediators and favors parasite infectivity towards J774 murine macrophages

Autor: Marine, Leroux, Hana, Bouazizi-Ben Messaoud, Céline, Luquain-Costaz, Lars P, Jordheim, Pauline, Le Faouder, Marie-Paule, Gustin, Karim, Aoun, Philippe, Lawton, Samira, Azzouz-Maache, Isabelle, Delton

Publikováno v: Lipids
Lipids, 2023, 58 (2), pp.81-92. ⟨10.1002/lipd.12365⟩

Leishmania parasites are the causative agents of visceral or cutaneous leishmaniasis in humans and of canine leishmaniosis. The macrophage is the predilected host cell of Leishmania in which the promastigote stage is transformed into amastigote. We p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::f1c06c8fba26809186d1985b044499f3
https://hal.science/hal-04158694/document

ADP ribosylation factor like 2 (Arl2) regulates breast tumor aggressivity in immunodeficient mice

Autor: Anne, Beghin, Stéphane, Belin, Rouba, Hage-Sleiman, Rouba, Hage Sleiman, Stéphanie, Brunet Manquat, Sophie, Goddard, Eric, Tabone, Lars P, Jordheim, Isabelle, Treilleux, Marie-France, Poupon, Jean-Jacques, Diaz, Charles, Dumontet

Publikováno v: PLoS ONE, Vol 4, Iss 10, p e7478 (2009)
PLoS ONE
PLoS ONE, Public Library of Science, 2009, 4 (10), pp.e7478. ⟨10.1371/journal.pone.0007478⟩
PLoS ONE, 2009, 4 (10), pp.e7478. ⟨10.1371/journal.pone.0007478⟩
Plos One 10 (4), 8 p.. (2009)

International audience; We have previously reported that ADP ribosylation factor like 2 (Arl2), a small GTPase, content influences microtubule dynamics and cell cycle distribution in breast tumor cells, as well as the degree and distribution of phosp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::81a75dc7002a7b62fe1bcc4355f8d2b2
http://europepmc.org/articles/PMC2759505?pdf=render

[Metabolism, mechanism of action and resistance to cytotoxic nucleoside analogues]

Autor: Lars P, Jordheim, Carlos M, Galmarini, Charles, Dumontet

Publikováno v: Bulletin du cancer. 92(3)

Cytotoxic nucleoside analogues are widely used in treatment of patients with hematological malignancies as well as for some solid tumors. Resistance developed against these molecules limit their clinical use. Many studies on cell models and clinical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::2de2a67ae0d3747f21c7c6973a292a72
https://pubmed.ncbi.nlm.nih.gov/15820918