Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Lars P van der Heide"'
Autor:
Markus Dahl, Varun Maturi, Peter Lönn, Panagiotis Papoutsoglou, Agata Zieba, Michael Vanlandewijck, Lars P van der Heide, Yukihide Watanabe, Ola Söderberg, Michael O Hottiger, Carl-Henrik Heldin, Aristidis Moustakas
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e103651 (2014)
Initiation, amplitude, duration and termination of transforming growth factor β (TGFβ) signaling via Smad proteins is regulated by post-translational modifications, including phosphorylation, ubiquitination and acetylation. We previously reported t
Externí odkaz:
https://doaj.org/article/071854e0854d45cb82760da367f931e6
Autor:
Elisa J Hoekstra, Lars von Oerthel, Lars P van der Heide, Willemieke M Kouwenhoven, Jesse V Veenvliet, Iris Wever, Yong-Ri Jin, Jeong K Yoon, Annemarie J A van der Linden, Frank C P Holstege, Marian J Groot Koerkamp, Marten P Smidt
Publikováno v:
PLoS ONE, Vol 8, Iss 9, p e74049 (2013)
Recent developments in molecular programming of mesodiencephalic dopaminergic (mdDA) neurons have led to the identification of many transcription factors playing a role in mdDA specification. LIM homeodomain transcription factor Lmx1a is essential fo
Externí odkaz:
https://doaj.org/article/e355db02b3224d99b2f94279dd033c23
Autor:
Edward J. Robinson, Sebastian P. Aguiar, Willemieke M. Kouwenhoven, Dorinde S. Starmans, Lars von Oerthel, Marten P. Smidt, Lars P. van der Heide
Publikováno v:
Cell Death Discovery, Vol 8, Iss 1, Pp 1-2 (2022)
Externí odkaz:
https://doaj.org/article/2a2307ee015e4e5c896f5eb9fed2d618
Publikováno v:
Cancers, Vol 13, Iss 13, p 3377 (2021)
Transforming growth factor-β (TGF-β) signaling plays a key role in governing various cellular processes, extending from cell proliferation and apoptosis to differentiation and migration. Due to this extensive involvement in the regulation of cellul
Externí odkaz:
https://doaj.org/article/52a5ac4fe13b411d8e33df05b68014bc
Publikováno v:
Trends in Molecular Medicine. 25:1056-1065
Dopamine neurons in the substantia nigra (SN) pars compacta are selectively lost during the progression of Parkinson's disease (PD). Recent work performed on the role of the Bcl2 family (highly specialized proteins which control cellular survival and
Publikováno v:
Cancers
Cancers, Vol 13, Iss 3377, p 3377 (2021)
Cancers, Vol 13, Iss 3377, p 3377 (2021)
Transforming growth factor-β (TGF-β) signaling plays a key role in governing various cellular processes, extending from cell proliferation and apoptosis to differentiation and migration. Due to this extensive involvement in the regulation of cellul
Autor:
Dorinde S. Starmans, Lars P. van der Heide, Lars von Oerthel, Sebastian Aguiar, Willemieke M. Kouwenhoven, Edward J. Robinson, Marten P. Smidt
Publikováno v:
Cell Death Discovery
Cell Death Discovery, Vol 4, Iss 1, Pp 1-13 (2018)
Cell death discovery, 4:107. Nature Publishing Group
Cell Death Discovery, Vol 4, Iss 1, Pp 1-13 (2018)
Cell death discovery, 4:107. Nature Publishing Group
Mitochondria-dependent apoptosis plays an important role in the embryonic development of the midbrain dopaminergic system as well as in Parkinson’s disease. Central to mitochondria-dependent apoptosis is the Bcl2 family of apoptosis-regulating prot
Autor:
Patrick J. Wijchers, Marten P. Smidt, Lars von Oerthel, Lars P. van der Heide, J. Peter H. Burbach, Marco F.M. Hoekman
Publikováno v:
Journal of Cellular Physiology. 230:1013-1023
FoxK2 is a forkhead transcription factor expressed ubiquitously in the developing murine central nervous system. Here we investigated the role of FoxK2 in vitro and focused on proliferation and cellular survival. Knockdown of FoxK2 results in a decre
Autor:
Frank C. P. Holstege, Gerard Scheppink, Marian J.A. Groot-Koerkamp, Lars von Oerthel, Raymond D. Schellevis, Lars P. van der Heide, Elisa J. Hoekstra, Marten P. Smidt, Annemarie J. A. van der Linden
Publikováno v:
European Journal of Neuroscience, 37(1), 23-32. Wiley-Blackwell
The LIM homeodomain transcription factor Lmx1a is a very potent inducer of stem cells towards dopaminergic neurons. Despite several studies on the function of this gene, the exact in vivo role of Lmx1a in mesodiencephalic dopamine (mdDA) neuronal spe
Autor:
Marco F.M. Hoekman, Frank M. J. Jacobs, Lars P. van der Heide, J. Peter H. Burbach, Marten P. Smidt
Publikováno v:
Biochemical Journal. 391:623-629
Forkhead members of the ‘O’ class (FoxO) are transcription factors crucial for the regulation of metabolism, cell cycle, cell death and cell survival. FoxO factors are regulated by insulin-mediated activation of PI3K (phosphoinositide 3-kinase)