Zobrazeno 1 - 10
of 100
pro vyhledávání: '"Lars P Erwig"'
Autor:
Qinxi Ma, Arnab Pradhan, Ian Leaves, Emer Hickey, Elena Roselletti, Ivy Dambuza, Daniel E. Larcombe, Leandro Jose de Assis, Duncan Wilson, Lars P. Erwig, Mihai G. Netea, Delma S. Childers, Gordon D. Brown, Neil A.R. Gow, Alistair J.P. Brown
Publikováno v:
The Cell Surface, Vol 11, Iss , Pp 100128- (2024)
Host recognition of the pathogen-associated molecular pattern (PAMP), β-1,3-glucan, plays a major role in antifungal immunity. β-1,3-glucan is an essential component of the inner cell wall of the opportunistic pathogen Candida albicans. Most β-1,3
Externí odkaz:
https://doaj.org/article/246a9682c09641f7a0a0fda1cc487324
Autor:
Gabriela M. Avelar, Arnab Pradhan, Qinxi Ma, Emer Hickey, Ian Leaves, Corin Liddle, Alejandra V. Rodriguez Rondon, Ann-Kristin Kaune, Sophie Shaw, Corinne Maufrais, Natacha Sertour, Judith M. Bain, Daniel E. Larcombe, Leandro J. de Assis, Mihai G. Netea, Carol A. Munro, Delma S. Childers, Lars P. Erwig, Gordon D. Brown, Neil A. R. Gow, Marie-Elisabeth Bougnoux, Christophe d'Enfert, Alistair J. P. Brown
Publikováno v:
mBio, Vol 15, Iss 2 (2024)
ABSTRACT Microbial species capable of co-existing with healthy individuals, such as the commensal fungus Candida albicans, exploit multifarious strategies to evade our immune defenses. These strategies include the masking of immunoinflammatory pathog
Externí odkaz:
https://doaj.org/article/a315d65d8db7474e9c59617b6af6132d
Autor:
María Fernanda Alonso, Judith M. Bain, Fiona M. Rudkin, Lars P. Erwig, Alistair J.P. Brown, Neil A.R. Gow
Publikováno v:
The Cell Surface, Vol 9, Iss , Pp 100106- (2023)
Externí odkaz:
https://doaj.org/article/30426ef88bc143d598db4acfd6573381
Autor:
Leandro José de Assis, Judith M. Bain, Corin Liddle, Ian Leaves, Christian Hacker, Roberta Peres da Silva, Raif Yuecel, Attila Bebes, David Stead, Delma S. Childers, Arnab Pradhan, Kevin Mackenzie, Katherine Lagree, Daniel E. Larcombe, Qinxi Ma, Gabriela Mol Avelar, Mihai G. Netea, Lars P. Erwig, Aaron P. Mitchell, Gordon D. Brown, Neil A. R. Gow, Alistair J. P. Brown
Publikováno v:
mBio, Vol 13, Iss 6 (2022)
ABSTRACT Candida albicans exists as a commensal of mucosal surfaces and the gastrointestinal tract without causing pathology. However, this fungus is also a common cause of mucosal and systemic infections when antifungal immune defenses become compro
Externí odkaz:
https://doaj.org/article/7eee21d07077458d862a678b6efa049c
Autor:
Gabriela M. Avelar, Ivy M. Dambuza, Liviana Ricci, Raif Yuecel, Kevin Mackenzie, Delma S. Childers, Judith M. Bain, Arnab Pradhan, Daniel E. Larcombe, Mihai G. Netea, Lars P. Erwig, Gordon D. Brown, Sylvia H. Duncan, Neil A.R. Gow, Alan W. Walker, Alistair J.P. Brown
Publikováno v:
The Cell Surface, Vol 8, Iss , Pp 100084- (2022)
The immunogenicity of Candida albicans cells is influenced by changes in the exposure of microbe-associated molecular patterns (MAMPs) on the fungal cell surface. Previously, the degree of exposure on the C. albicans cell surface of the immunoinflamm
Externí odkaz:
https://doaj.org/article/369d68d889004bc9b1d341433c89942b
Autor:
María Fernanda Alonso, Judith M. Bain, Fiona M. Rudkin, Lars P. Erwig, Alistair J.P. Brown, Neil A.R. Gow
Publikováno v:
The Cell Surface, Vol 8, Iss , Pp 100082- (2022)
Phagocytosis is an essential component of our immune defence against fungal pathogens. Differences in the dynamics of phagocyte migration, recognition, uptake and phagolysosome maturation are dependent on the characteristics of the fungal cargo, and
Externí odkaz:
https://doaj.org/article/ccb6820628234afcb4260568f4e8cb07
Publikováno v:
Autoimmunity, Vol 53, Iss 3, Pp 148-155 (2020)
Neutrophils, monocytes and the endothelium are critical to ANCA-associated vasculitis (AAV) pathogenesis. This study aimed to develop a 4-dimensional (4D) live-cell imaging system that would enable investigation of spatial and temporal dynamics of th
Externí odkaz:
https://doaj.org/article/8afbe4f709564471b0feaa82daefd1d9
Autor:
Fiona M. Rudkin, Ingrida Raziunaite, Hillary Workman, Sosthene Essono, Rodrigo Belmonte, Donna M. MacCallum, Elizabeth M. Johnson, Lisete M. Silva, Angelina S. Palma, Ten Feizi, Allan Jensen, Lars P. Erwig, Neil A. R. Gow
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-16 (2018)
Late diagnosis and ineffective treatment of fungal infections lead to high mortality. Here, Rudkin et al. generate anti-Candida human monoclonal antibodies with diagnostic and therapeutic potential, by expressing recombinant antibodies from genes clo
Externí odkaz:
https://doaj.org/article/3962deb6cda443548deab4a2e58b1fbe
Autor:
Delma S. Childers, Gabriela Mol Avelar, Judith M. Bain, Arnab Pradhan, Daniel E. Larcombe, Mihai G. Netea, Lars P. Erwig, Neil A. R. Gow, Alistair J. P. Brown
Publikováno v:
mBio, Vol 11, Iss 4 (2020)
ABSTRACT The cell wall provides a major physical interface between fungal pathogens and their mammalian host. This extracellular armor is critical for fungal cell homeostasis and survival. Fungus-specific cell wall moieties, such as β-1,3-glucan, ar
Externí odkaz:
https://doaj.org/article/4da9c9b4bb334467bcbb87a32cd2e4e6
Autor:
Mohammed Haider, Ivy M Dambuza, Patawee Asamaphan, Mark Stappers, Delyth Reid, Sho Yamasaki, Gordon D Brown, Neil A R Gow, Lars P Erwig
Publikováno v:
PLoS ONE, Vol 14, Iss 8, p e0220867 (2019)
Phagocytosis is a receptor-mediated process critical to innate immune clearance of pathogens. It proceeds in a regulated sequence of stages: (a) migration of phagocytes towards pathogens, (b) recognition of PAMPs and binding through PRRs, (c) engulfm
Externí odkaz:
https://doaj.org/article/75cdbb4d019d4cd7b8d1cd3b3de8f628