Zobrazeno 1 - 10
of 140
pro vyhledávání: '"Lars Nitschke"'
Autor:
Michael Schmidt, Alexandra T. Linder, Marina Korn, Nick Schellenberg, Sarah J. Meyer, Falk Nimmerjahn, Anja Werner, Markus Abeln, Rita Gerardy-Schahn, Anja K. Münster-Kühnel, Lars Nitschke
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Sialic acids are found as terminal sugars on glycan structures on cellular surfaces. T cells carry these sialoglycans abundantly, and they are thought to serve multiple functions in cell adhesion, cell migration, and protection from complement attack
Externí odkaz:
https://doaj.org/article/8c5b3ce0d2684371a533192aaf40fe7f
Autor:
Anja Werner, Maja Hanić, Olga O. Zaitseva, Gordan Lauc, Anja Lux, Lars Nitschke, Falk Nimmerjahn
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Sialic acids as terminal sugar residues on cell surface or secreted proteins have many functional roles. In particular, the presence or absence of α2,6-linked sialic acid residues at the immunoglobulin G (IgG) Fc fragment can switch IgG effector fun
Externí odkaz:
https://doaj.org/article/fbcd82a43baa4efd82f1ba071fcafe7a
Autor:
Marina A. Korn, Marie Steffensen, Carolin Brandl, Dmytro Royzman, Christoph Daniel, Thomas H. Winkler, Lars Nitschke
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Systemic lupus erythematosus (SLE) is a severe autoimmune disease that displays considerable heterogeneity not only in its symptoms, but also in its environmental and genetic causes. Studies in SLE patients have revealed that many genetic variants co
Externí odkaz:
https://doaj.org/article/64c20df68051432f9f311146a4f6e232
Autor:
Timo Vögtle, Ayesha A. Baig, Julia Volz, Timothy B. Duchow, Irina Pleines, Sebastian Dütting, Lars Nitschke, Stephen P. Watson, Bernhard Nieswandt
Publikováno v:
Platelets, Vol 31, Iss 6, Pp 801-811 (2020)
Platelets are essential for normal hemostasis; however, pathological conditions can also trigger unwanted platelet activation precipitating thrombosis and ischemic damage of vital organs such as the heart or brain. Glycoprotein (GP)VI- and C-type lec
Externí odkaz:
https://doaj.org/article/b84ba99bcc4f4a65985d1c482889fe84
Autor:
Vera Kristin Schmid, Ahmad Khadour, Nabil Ahmed, Carolin Brandl, Lars Nitschke, Klaus Rajewsky, Hassan Jumaa, Elias Hobeika
Publikováno v:
Haematologica, Vol 107, Iss 8 (2022)
Chronic lymphocytic leukemia (CLL) is a frequent lymphoproliferative disorder of B cells. Although inhibitors targeting signal proteins involved in B-cell antigen receptor (BCR) signaling constitute an important part of the current therapeutic protoc
Externí odkaz:
https://doaj.org/article/e5c0a11a07cd48aebe8e319f62fac762
Autor:
Nadine Szumilas, Odilia B. J. Corneth, Christian H. K. Lehmann, Heike Schmitt, Svenia Cunz, Jolie G. Cullen, Talyn Chu, Anita Marosan, Attila Mócsai, Vladimir Benes, Dietmar Zehn, Diana Dudziak, Rudi W. Hendriks, Lars Nitschke
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Siglec-H is a DAP12-associated receptor on plasmacytoid dendritic cells (pDCs) and microglia. Siglec-H inhibits TLR9-induced IFN-α production by pDCs. Previously, it was found that Siglec-H-deficient mice develop a lupus-like severe autoimmune disea
Externí odkaz:
https://doaj.org/article/c505db08fdab443ead7dba66ecb91da3
Autor:
Carolin Ulbricht, Ruth Leben, Asylkhan Rakhymzhan, Frank Kirchhoff, Lars Nitschke, Helena Radbruch, Raluca A Niesner, Anja E Hauser
Publikováno v:
eLife, Vol 10 (2021)
Calcium is a universal second messenger present in all eukaryotic cells. The mobilization and storage of Ca2+ ions drives a number of signaling-related processes, stress–responses, or metabolic changes, all of which are relevant for the development
Externí odkaz:
https://doaj.org/article/23cb8f32d40044f082c0f1a13df9a9ce
Autor:
Vitor E Fernandes, Giuseppe Ercoli, Alan Bénard, Carolin Brandl, Hannah Fahnenstiel, Jennifer Müller-Winkler, Georg F Weber, Paul Denny, Lars Nitschke, Peter W Andrew
Publikováno v:
PLoS Pathogens, Vol 16, Iss 4, p e1008464 (2020)
Streptococcus pneumoniae is a major human pathogen, causing pneumonia and sepsis. Genetic components strongly influence host responses to pneumococcal infections, but the responsible loci are unknown. We have previously identified a locus on mouse ch
Externí odkaz:
https://doaj.org/article/07bcfc37f2ab46e9a4c9cab408037570
Autor:
Anja Schaffert, Maja Hanić, Mislav Novokmet, Olga Zaytseva, Jasminka Krištić, Anja Lux, Lars Nitschke, Matthias Peipp, Marija Pezer, René Hennig, Erdmann Rapp, Gordan Lauc, Falk Nimmerjahn
Publikováno v:
Frontiers in Immunology, Vol 10 (2020)
Select residues in the biantennary sugar moiety attached to the fragment crystallizable of immunoglobulin G (IgG) antibodies can modulate IgG effector functions. Thus, afucosylated IgG glycovariants have enhanced cytotoxic activity, whereas IgG glyco
Externí odkaz:
https://doaj.org/article/1d611dbd27574706bdc1efeaf803f067
Publikováno v:
Frontiers in Immunology, Vol 9 (2018)
CD22 and Siglec-G are members of the Siglec family. Both are inhibitory co-receptors on the surface of B cells and inhibit B-cell receptor induced signaling, characterized by inhibition of the calcium mobilization and cellular activation. CD22 functi
Externí odkaz:
https://doaj.org/article/b48c6c77f4934a069d1f982370f20fec