Topical Neuropeptide Y for Ischemic Skin Wounds

Autor: Tais Stangerup, Lise Mette Rahbek Gjerdrum, Michael Bzorek, Line Andersen, Anne-Marie Heegaard, Lars N. Jorgensen, Magnus S. Ågren

Publikováno v: International Journal of Molecular Sciences, Vol 25, Iss 6, p 3346 (2024)

Our objective was to investigate the effects of topically applied neuropeptide Y (NPY) on ischemic wounds. Initially, the animal model for ischemic wound healing was validated using 16 male Sprague Dawley albino rats. In the intervention study, an ad

Externí odkaz: https://doaj.org/article/719364a3cdc74717972dc5be15a2aa06

Plasma Kallikrein-Activated TGF-β Is Prognostic for Poor Overall Survival in Patients with Pancreatic Ductal Adenocarcinoma and Associates with Increased Fibrogenesis

Autor: Rasmus S. Pedersen, Neel I. Nissen, Christina Jensen, Jeppe Thorlacius-Ussing, Tina Manon-Jensen, Majken L. Olesen, Lasse L. Langholm, Hadi M. H. Diab, Lars N. Jorgensen, Carsten P. Hansen, Inna M. Chen, Julia S. Johansen, Morten A. Karsdal, Nicholas Willumsen

Publikováno v: Biomolecules, Vol 12, Iss 9, p 1315 (2022)

Pancreatic ductal adenocarcinoma (PDAC) is a hard-to-treat cancer due to the collagen-rich (fibrotic) and immune-suppressed microenvironment. A major driver of this phenomenon is transforming growth factor beta (TGF-β). TGF-β is produced in an inac

Externí odkaz: https://doaj.org/article/090d7e20b41848078ab5b37623004dd1

Spatial expression of metallothionein, matrix metalloproteinase-1 and Ki-67 in human epidermal wounds treated with zinc and determined by quantitative immunohistochemistry: A randomised double-blind trial

Autor: Magnus S. Ågren, Lana Chafranska, Jens Ole Eriksen, Julie Lyng Forman, Morten J. Bjerrum, Peter Schjerling, Heidi F. Larsen, Elena Cottarelli, Lars N. Jorgensen, Lise Mette Rahbek Gjerdrum

Publikováno v: European Journal of Cell Biology, Vol 100, Iss 3, Pp 151147- (2021)

Reepithelialisation is fundamental to wound healing, but our current understanding largely relies on cellular and animal studies. The aim of the present randomised double-blind three-arm controlled trial was to correlate genuine epidermal wound heali

Externí odkaz: https://doaj.org/article/b2c2be370aaa4b318c1f0ea07baea118

Even minor alteration of plasma creatinine after open abdominal surgery is associated with 30-day mortality: A single-centre cohort study

Autor: H.L. Jørgensen, A.K. Nordklint, K.K. Jensen, S. Soltanizadeh, Lars N. Jorgensen

Publikováno v: Soltanizadeh, S, Kiim Jensen, K, Karahasanovic Nordklint, A, Løvendahl Jørgensen, H & Nannestad Jørgensen, L 2023, ' Even minor alteration of plasma creatinine after open abdominal surgery is associated with 30-day mortality : A single-centre cohort study ', Journal of visceral surgery, vol. 160, no. 1, pp. 19-26 . https://doi.org/10.1016/j.jviscsurg.2021.10.008

Purpose: Postoperative acute kidney injury is common and associated with increased length of hospital stay, costs and mortality. The impact from postoperative subclinical changes in plasma concentration of creatinine (p-creatinine) on postoperative m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c8c83379e6432e454041c9159a5edf49
https://doi.org/10.1016/j.jviscsurg.2021.10.008

Glucagon-Like Peptide-2 Analogue ZP1849 Augments Colonic Anastomotic Wound Healing

Autor: Marie Kjaer, Wayne Russell, Peter Schjerling, Elena Cottarelli, Kennet N. Christjansen, Ditte M. G. Olsen, Peter-Martin Krarup, Lene Jessen, Mark Berner-Hansen, Lars N. Jorgensen, Magnus S. Ågren

Publikováno v: Gastroenterology Research and Practice, Vol 2020 (2020)

Background. The enteroendocrine hormone glucagon-like peptide- (GLP-) 2 is a potent trophic factor in the gastrointestinal tract. The GLP-2 receptor (GLP-2R) is expressed in the stroma of the large bowel wall, which is the major therapeutic target ar

Externí odkaz: https://doaj.org/article/3941f570c9da470fb31cf22360242260