Zobrazeno 1 - 10
of 95
pro vyhledávání: '"Lars Michel"'
Autor:
Lars Michel, Stefanie Jehn, Iryna Dykun, Markus S. Anker, Peter Ferdinandy, Dobromir Dobrev, Tienush Rassaf, Amir A. Mahabadi, Matthias Totzeck
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 52, Iss , Pp 101419- (2024)
Background: Cardiac troponin I (cTnI) above the 99th percentile is associated with an increased risk of major adverse events. Patients with detectable cTnI below the 99th percentile are a heterogeneous group with a less well-defined risk profile. The
Externí odkaz:
https://doaj.org/article/ac8efc9d3649454583bc0021fb01ddbe
Autor:
Julia Pohl, Matthias Totzeck, Raluca‐I. Mincu, Simone M. Margraf, Lena Scheipers, Lars Michel, Amir A. Mahabadi, Lisa Zimmer, Tienush Rassaf, Ulrike B. Hendgen‐Cotta
Publikováno v:
ESC Heart Failure, Vol 9, Iss 5, Pp 3533-3542 (2022)
Abstract Aims While immune checkpoint inhibitor (ICI) therapy significantly improves survival rates in advanced melanoma, ICI can evoke severe immune‐related cardiovascular adverse events. Right ventricular (RV) dysfunction negatively impacts the o
Externí odkaz:
https://doaj.org/article/aae44109e7774531bdcef5596b923f82
Autor:
Amir A. Mahabadi, Raluca Mincu, Iryna Dykun, Lars Michel, Alexander Küng, Oliver Witzke, Clemens Kill, Jan Buer, Tienush Rassaf, Matthias Totzeck
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 45, Iss , Pp 101184- (2023)
Background: The COVID-19 pandemic led to an alteration of algorithms in emergency medicine, which may influence the management of patients with similar symptoms but underlying cardiovascular diseases. We evaluated key differential diagnoses to acute
Externí odkaz:
https://doaj.org/article/1863dd1034124b148c2cc5d1150c5149
Autor:
Sebastian Korste, Stephan Settelmeier, Lars Michel, Andrea Odersky, Pia Stock, Fabrice Reyes, Elias Haj-Yehia, Markus S. Anker, Anika Grüneboom, Ulrike B. Hendgen-Cotta, Tienush Rassaf, Matthias Totzeck
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 7, p 6052 (2023)
Cancer survival rates have increased significantly because of improvements in therapy regimes and novel immunomodulatory drugs. Recently, combination therapies of anthracyclines and immune checkpoint inhibitors (ICIs) have been proposed to maximize n
Externí odkaz:
https://doaj.org/article/663aacb6082341939843d1d2a1a8eedb
Autor:
Lars Michel, Raluca I. Mincu, Simone M. Mrotzek, Sebastian Korste, Ulrich Neudorf, Tienush Rassaf, Matthias Totzeck
Publikováno v:
ESC Heart Failure, Vol 7, Iss 2, Pp 423-433 (2020)
Abstract Aims Childhood cancer therapy is associated with a significant risk of therapy‐related cardiotoxicity. This meta‐analysis aims to evaluate cardiac biomarkers for the detection of cancer therapy‐related left ventricular (LV) dysfunction
Externí odkaz:
https://doaj.org/article/9c7ced8031624bcca594b90c48bfc901
Autor:
Lars Michel, Sebastian Korste, Armin Spomer, Ulrike Barbara Hendgen-Cotta, Tienush Rassaf, Matthias Totzeck
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 14, p 7533 (2022)
The programmed cell death protein 1 (PD1) immune checkpoint prevents inflammatory tissue damage by inhibiting immune reactions. Understanding the relevance of cardiac PD1 signaling may provide new insights into the inflammatory events under baseline
Externí odkaz:
https://doaj.org/article/d8744110f0e2409aafff857aeab3a285
Autor:
Simon F. Merz, Sebastian Korste, Lea Bornemann, Lars Michel, Pia Stock, Anthony Squire, Camille Soun, Daniel R. Engel, Julia Detzer, Holger Lörchner, Dirk M. Hermann, Markus Kamler, Joachim Klode, Ulrike B. Hendgen-Cotta, Tienush Rassaf, Matthias Gunzer, Matthias Totzeck
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Detailed characterization of cardiac damage following ischemia/reperfusion injury and detection of occurring inflammatory responses is important for the development of new therapeutic concepts. Here the authors present a method for the three-dimensio
Externí odkaz:
https://doaj.org/article/3e96cf3e564a4e068419e2da632f2557
Autor:
Lars Michel, Tienush Rassaf
Publikováno v:
European Journal of Medical Research, Vol 24, Iss 1, Pp 1-4 (2019)
Abstract Cancer and cardiovascular diseases are the main causes for morbidity and mortality in modern society. In the United States of America (USA), over 1.7 million new cancer cases will presumably be observed in 2018. Progress in cancer treatment
Externí odkaz:
https://doaj.org/article/5aa9aa149d704844b27422d67f1d5cfa
Autor:
Lena Hinrichs, Simone Maria Mrotzek, Raluca-Ileana Mincu, Julia Pohl, Alina Röll, Lars Michel, Amir Abbas Mahabadi, Fadi Al-Rashid, Matthias Totzeck, Tienush Rassaf
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
BackgroundThe long-term survival of cancer patients has significantly improved over the past years. Despite their therapeutic efficacy, various cancer therapies are associated with cardiotoxicity. Therefore, timely detection of cardiotoxic adverse ev
Externí odkaz:
https://doaj.org/article/dfd54dc3705a4b2593a6cdc27afb4141
Publikováno v:
International Journal of Cardiology: Heart & Vasculature, Vol 25, Iss , Pp - (2019)
Immune checkpoint inhibitor (ICI) therapy has greatly improved treatment of various advanced cancers but increasing use of ICI therapy has exposed the risk of ICI-related cardiovascular side effects.Immune checkpoints are inhibitory regulators of T c
Externí odkaz:
https://doaj.org/article/32f293d42b754d5386f600bcd56e0cc3