Zobrazeno 1 - 10
of 52
pro vyhledávání: '"Lars Mecklenburg"'
Autor:
Sebastian Peters, Eva Wirkert, Sabrina Kuespert, Rosmarie Heydn, Sven Korte, Lars Mecklenburg, Ludwig Aigner, Siw Johannesen, Tim-Henrik Bruun, Ulrich Bogdahn
Publikováno v:
Applied Sciences, Vol 12, Iss 3, p 973 (2022)
Increasingly antisense oligonucleotides (ASOs) are developed for potential treatment of CNS disorders, and due to the inability to cross the blood brain barrier, they require direct administration into the cerebrospinal fluid (CSF). In this regard, i
Externí odkaz:
https://doaj.org/article/4027f861493a47a29d8001e8f86f1eb9
Autor:
Sebastian Peters, Eva Wirkert, Sabrina Kuespert, Rosmarie Heydn, Siw Johannesen, Anita Friedrich, Susanne Mailänder, Sven Korte, Lars Mecklenburg, Ludwig Aigner, Tim-Henrik Bruun, Ulrich Bogdahn
Publikováno v:
Pharmaceutics, Vol 14, Iss 1, p 200 (2022)
The capability of the adult central nervous system to self-repair/regenerate was demonstrated repeatedly throughout the last decades but remains in debate. Reduced neurogenic niche activity paralleled by a profound neuronal loss represents fundamenta
Externí odkaz:
https://doaj.org/article/2be091cb44884b99a0ace5ee62d10f3a
Autor:
Christoph Holmer, Christiane Praechter, Lars Mecklenburg, Markus Heimesaat, Hayo Rieger, Uwe Pohlen
Publikováno v:
Asian Journal of Surgery, Vol 37, Iss 1, Pp 35-45 (2014)
Background/Objective: Anastomotic insufficiency is associated with increased morbidity and mortality. A collagen fleece that supports anastomosis is effective for preventing anastomosis insufficiency. The objective of this study was to compare betwee
Externí odkaz:
https://doaj.org/article/31c1dc69056048aa872eb143e53f23a7
Autor:
Gerhard Weinbauer, Lars Mecklenburg
Publikováno v:
Toxicologic Pathology. 50:552-559
Long-tailed macaques are the predominant nonhuman primate species for the nonclinical safety testing of biopharmaceuticals. This species comprises 9 subspecies with Macaca fascicularis fascicularis naturally occurring in Southeast Asia. Since the 17t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::56800a87e9183496768906542e4a0f75
https://doi.org/10.1177/01926233221095443
https://doi.org/10.1177/01926233221095443
Safety assessment of human pharmaceuticals demands extensive animal experiments before a compound can be tested in patients or released on the market. Such experiments typically include concurrent vehicle control groups. Reconsidering the need for co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::066a203abde3950314b6fba8ff034f40
https://doi.org/10.1101/2023.02.15.528719
https://doi.org/10.1101/2023.02.15.528719
Autor:
Lars Mecklenburg, Rebecca Ducore, Molly Boyle, Andrew Newell, Laura Boone, Joerg Luft, Annette Romeike, Ann-Kathrin Haverkamp, Keith Mansfield, JJ Baczenas, Nick Minor, Shelby L. O’Connor, David H. O’Connor
Hepatitis A virus (HAV) infects humans and non-human primates causing an acute self-limited illness. Three HAV genotypes have been described for humans and three genotypes have been described for non-human primates. We observed transiently elevated l
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::feff11afc3b3550406a6882950b03644
https://doi.org/10.1101/2022.11.18.515766
https://doi.org/10.1101/2022.11.18.515766
Autor:
Magdalena Wozniak, Jorge Luft, Peter Korytko, F. Runge, Serge Zander, Lars Mecklenburg, Anne von Keutz, Florian Timo Ludwig, Betina Pajaziti, Annette Romeike, Sven Korte
Publikováno v:
International Journal of Toxicology. 39:510-517
Many potential drugs for treatment of neurodegenerative diseases, particularly antisense oligonucleotides (ASOs), are administered via lumbar intrathecal injection, because these drugs do not cross the blood–brain barrier. Intrathecal injection is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::117e5caab55e193558a555cfe058c512
https://doi.org/10.1177/1091581820951098
https://doi.org/10.1177/1091581820951098
Autor:
Karyn, Colman, Rachel N, Andrews, Hannah, Atkins, Theresa, Boulineau, Alys, Bradley, Annamaria, Braendli-Baiocco, Raffaella, Capobianco, David, Caudell, Mark, Cline, Takuya, Doi, Rainer, Ernst, Eric, van Esch, Jeffrey, Everitt, Pierluigi, Fant, Margarita M, Gruebbel, Lars, Mecklenburg, Andew D, Miller, Kristen J, Nikula, Shigeru, Satake, Julie, Schwartz, Alok, Sharma, Akihito, Shimoi, Cécile, Sobry, Ian, Taylor, Vimala, Vemireddi, Justin, Vidal, Charles, Wood, John L, Vahle
Publikováno v:
Journal of Toxicologic Pathology
The INHAND (International Harmonization of Nomenclature and Diagnostic Criteria for Lesions Project (www.toxpath.org/inhand.asp) is a joint initiative of the Societies of Toxicologic Pathology from Europe (ESTP), Great Britain (BSTP), Japan (JSTP) an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e526dcfd7f7a5de8fc7b019878f90472
https://pubmed.ncbi.nlm.nih.gov/34712008
https://pubmed.ncbi.nlm.nih.gov/34712008
Autor:
Lars Mecklenburg, Almudena Fernández, Marta Cantero, Kevin Lin, Sharon Y.R. Dent, Carlos J. Perez, Tiago Antonio de Souza, Fernando Benavides, Alexander Awgulewitsch, Lluis Montoliu
Publikováno v:
Experimental dermatologyREFERENCES. 31(3)
Loss of function mutations in HOXC13 have been associated with Ectodermal Dysplasia-9, Hair/Nail Type (ECTD9) in consanguineous families, characterized by sparse to complete absence of hair and nail dystrophy. Here we characterize the spontaneous mou
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::455d78be00369cdf2c36e4ce3ea44976
https://pubmed.ncbi.nlm.nih.gov/34657330
https://pubmed.ncbi.nlm.nih.gov/34657330
Publikováno v:
Toxicologic Pathology. 47:444-460
If nonhuman primates represent the only relevant species for nonclinical safety evaluation of biotechnology-derived products, male and female fertility effects can be assessed in repeat dose toxicity studies given that sexually mature monkeys are use
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e56f1b25701902dc58c68515504a8c50
https://doi.org/10.1177/0192623319831009
https://doi.org/10.1177/0192623319831009