Zobrazeno 1 - 10
of 137
pro vyhledávání: '"Lars Malmström"'
Autor:
Arman Izadi, Yasaman Karami, Eleni Bratanis, Sebastian Wrighton, Hamed Khakzad, Maria Nyblom, Berit Olofsson, Lotta Happonen, Di Tang, Martin Sundwall, Magdalena Godzwon, Yashuan Chao, Alejandro Gomez Toledo, Tobias Schmidt, Mats Ohlin, Michael Nilges, Johan Malmström, Wael Bahnan, Oonagh Shannon, Lars Malmström, Pontus Nordenfelt
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-22 (2024)
Abstract Streptococcus pyogenes can cause invasive disease with high mortality despite adequate antibiotic treatments. To address this unmet need, we have previously generated an opsonic IgG1 monoclonal antibody, Ab25, targeting the bacterial M prote
Externí odkaz:
https://doaj.org/article/be6b5c313b7e4a23b226edf27ac9fea5
Autor:
Erik Hartman, Aaron M. Scott, Christofer Karlsson, Tirthankar Mohanty, Suvi T. Vaara, Adam Linder, Lars Malmström, Johan Malmström
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-13 (2023)
Abstract The incorporation of machine learning methods into proteomics workflows improves the identification of disease-relevant biomarkers and biological pathways. However, machine learning models, such as deep neural networks, typically suffer from
Externí odkaz:
https://doaj.org/article/6ba2704448034c108462da0c1d21a25d
Autor:
Tirthankar Mohanty, Christofer A. Q. Karlsson, Yashuan Chao, Erik Malmström, Eleni Bratanis, Andrietta Grentzmann, Martina Mørch, Victor Nizet, Lars Malmström, Adam Linder, Oonagh Shannon, Johan Malmström
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Abstract Sepsis is the major cause of mortality across intensive care units globally, yet details of accompanying pathological molecular events remain unclear. This knowledge gap has resulted in ineffective biomarker development and suboptimal treatm
Externí odkaz:
https://doaj.org/article/5bac18b01da14d49bb234886c176c6ba
Autor:
Aaron M. Scott, Christofer Karlsson, Tirthankar Mohanty, Erik Hartman, Suvi T. Vaara, Adam Linder, Johan Malmström, Lars Malmström
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-13 (2023)
Abstract Data independent acquisition mass spectrometry (DIA-MS) has recently emerged as an important method for the identification of blood-based biomarkers. However, the large search space required to identify novel biomarkers from the plasma prote
Externí odkaz:
https://doaj.org/article/c62f01db96f746e9960e9d6a3d365a00
Autor:
Tommaso De Marchi, Paul Theodor Pyl, Martin Sjöström, Susanne Erika Reinsbach, Sebastian DiLorenzo, Björn Nystedt, Lena Tran, Gyula Pekar, Fredrik Wärnberg, Irma Fredriksson, Per Malmström, Mårten Fernö, Lars Malmström, Johan Malmstöm, Emma Niméus
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-14 (2023)
A proteogenomic analysis of matching primary breast cancer and ipsilateral breast tumor recurrence (IBTR) samples provides insight into the development of IBTR and may be useful in identifying biomarkers for IBTR formation.
Externí odkaz:
https://doaj.org/article/7fcdfaaf09f349e4a6ae38eff9a3e17b
Autor:
Cesar Valencia-Gallardo, Daniel-Isui Aguilar-Salvador, Hamed Khakzad, Benjamin Cocom-Chan, Charles Bou-Nader, Christophe Velours, Yosra Zarrouk, Christophe Le Clainche, Christian Malosse, Diogo Borges Lima, Nicole Quenech’Du, Bilal Mazhar, Sami Essid, Marc Fontecave, Atef Asnacios, Julia Chamot-Rooke, Lars Malmström, Guy Tran Van Nhieu
Publikováno v:
Cell Reports, Vol 42, Iss 4, Pp 112405- (2023)
Summary: Upon activation, vinculin reinforces cytoskeletal anchorage during cell adhesion. Activating ligands classically disrupt intramolecular interactions between the vinculin head and tail domains that bind to actin filaments. Here, we show that
Externí odkaz:
https://doaj.org/article/c7264a6cb8d84810a58eacb247fd705e
Autor:
Wael Bahnan, Lotta Happonen, Hamed Khakzad, Vibha Kumra Ahnlide, Therese deNeergaard, Sebastian Wrighton, Oscar André, Eleni Bratanis, Di Tang, Thomas Hellmark, Lars Björck, Oonagh Shannon, Lars Malmström, Johan Malmström, Pontus Nordenfelt
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 2, Pp n/a-n/a (2023)
Abstract Group A streptococci have evolved multiple strategies to evade human antibodies, making it challenging to create effective vaccines or antibody treatments. Here, we have generated antibodies derived from the memory B cells of an individual w
Externí odkaz:
https://doaj.org/article/2bcb7da2abe14c5fb5c5a0341f1349d2
Multienzyme deep learning models improve peptide de novo sequencing by mass spectrometry proteomics.
Autor:
Carlos Gueto-Tettay, Di Tang, Lotta Happonen, Moritz Heusel, Hamed Khakzad, Johan Malmström, Lars Malmström
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 1, p e1010457 (2023)
Generating and analyzing overlapping peptides through multienzymatic digestion is an efficient procedure for de novo protein using from bottom-up mass spectrometry (MS). Despite improved instrumentation and software, de novo MS data analysis remains
Externí odkaz:
https://doaj.org/article/bff3bbae203c4c88bfe6f05962fd52bc
Autor:
Wael Bahnan, Sebastian Wrighton, Martin Sundwall, Anna Bläckberg, Olivia Larsson, Urban Höglund, Hamed Khakzad, Magdalena Godzwon, Maria Walle, Elisabeth Elder, Anna Söderlund Strand, Lotta Happonen, Oscar André, Johannes Kumra Ahnlide, Thomas Hellmark, Vidar Wendel-Hansen, Robert PA. Wallin, Johan Malmstöm, Lars Malmström, Mats Ohlin, Magnus Rasmussen, Pontus Nordenfelt
Publikováno v:
Frontiers in Immunology, Vol 12 (2022)
Spike-specific antibodies are central to effective COVID19 immunity. Research efforts have focused on antibodies that neutralize the ACE2-Spike interaction but not on non-neutralizing antibodies. Antibody-dependent phagocytosis is an immune mechanism
Externí odkaz:
https://doaj.org/article/f92905abfadc4d269db7f2ae1d052963
Autor:
Sounak Chowdhury, Hamed Khakzad, Gizem Ertürk Bergdahl, Rolf Lood, Simon Ekstrom, Dirk Linke, Lars Malmström, Lotta Happonen, Johan Malmström
Publikováno v:
mSystems, Vol 6, Iss 5 (2021)
ABSTRACT Streptococcus pyogenes is known to cause both mucosal and systemic infections in humans. In this study, we used a combination of quantitative and structural mass spectrometry techniques to determine the composition and structure of the inter
Externí odkaz:
https://doaj.org/article/80c18bcd4e8f49eb99487dfa43a93bf6