Zobrazeno 1 - 10
of 219
pro vyhledávání: '"Lars M. Ittner"'
Autor:
Katherine Phan, Ying He, YuHong Fu, Nicolas Dzamko, Surabhi Bhatia, Julian Gold, Dominic Rowe, Yazi D. Ke, Lars M. Ittner, John R. Hodges, Olivier Piguet, Matthew C. Kiernan, Glenda M. Halliday, Woojin Scott Kim
Publikováno v:
Communications Medicine, Vol 1, Iss 1, Pp 1-11 (2021)
Phan et al. assess the presence of human endogenous retrovirus K (HERV-K) in the serum and brain samples of individuals with behavioral variant frontotemporal dementia (bvFTD) with TDP-43 pathology, as seen in amyotrophic lateral sclerosis. The autho
Externí odkaz:
https://doaj.org/article/db876dcb79914f2f8c9e124f72da54ce
Autor:
Julia van der Hoven, Annika van Hummel, Magdalena Przybyla, Prita R. Asih, Mehul Gajwani, Astrid F. Feiten, Yazi D. Ke, Arne Ittner, Janet van Eersel, Lars M. Ittner
Publikováno v:
Scientific Reports, Vol 10, Iss 1, Pp 1-16 (2020)
Abstract Antibodies have been explored extensively as a potential therapeutic for Alzheimer’s disease, where amyloid-β (Aβ) peptides and the tau protein deposit in patient brains. While the major focus of antibody-based therapy development was on
Externí odkaz:
https://doaj.org/article/7542fd4f0b3143c8a94362ae7f8f1328
Autor:
Lu Yang, Zhiliang Chen, Elizabeth S. Stout, Fabien Delerue, Lars M. Ittner, Marc R. Wilkins, Kate G. R. Quinlan, Merlin Crossley
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
While DNA methylation is thought to play a regulatory role, there are few examples where modification of a single CpG dinucleotide directly affects transcription factor binding. Here the authors show that methylation of a single CGATA element within
Externí odkaz:
https://doaj.org/article/b4acfc4575304524ad85c29fe8eab477
Autor:
Daryl Ariawan, Carol Au, Esmeralda Paric, Thomas Fath, Yazi D. Ke, Michael Kassiou, Janet van Eersel, Lars M. Ittner
Publikováno v:
Frontiers in Chemistry, Vol 9 (2021)
The LIM-domain kinase (LIMK) family consists of two isoforms, LIMK1 and LIMK2, which are highly homologous, making selective inhibitor development challenging. LIMK regulates dynamics of the actin cytoskeleton, thereby impacting many cellular functio
Externí odkaz:
https://doaj.org/article/6f64097e86454ff89c0370f47fad2bdb
Efficient Gene Expression in Human Stem Cell Derived-Cortical Organoids Using Adeno Associated Virus
Publikováno v:
Cells, Vol 11, Iss 20, p 3194 (2022)
Cortical organoids are 3D structures derived either from human embryonic stem cells or human induced pluripotent stem cells with their use exploding in recent years due to their ability to better recapitulate the human brain in vivo in respect to org
Externí odkaz:
https://doaj.org/article/1539950e54e0445ab3eb68881431afc4
Autor:
Ye Zhao, Shikara Keshiya, Farzaneh Atashrazm, Jianqun Gao, Lars M. Ittner, Dario R. Alessi, Glenda M. Halliday, Yuhong Fu, Nicolas Dzamko
Publikováno v:
Neurobiology of Disease, Vol 120, Iss , Pp 76-87 (2018)
Leucine-rich repeat kinase 2 (LRRK2) is genetically implicated in both familial and sporadic Parkinson's disease (PD). Moreover, LRRK2 has emerged as a compelling therapeutic target for the treatment of PD. Consequently, there is much interest in und
Externí odkaz:
https://doaj.org/article/f2082b29b24e4f84a085a33e3cf719f6
Autor:
Mian Bi, Amadeus Gladbach, Janet van Eersel, Arne Ittner, Magdalena Przybyla, Annika van Hummel, Sook Wern Chua, Julia van der Hoven, Wei S. Lee, Julius Müller, Jasneet Parmar, Georg von Jonquieres, Holly Stefen, Ernesto Guccione, Thomas Fath, Gary D. Housley, Matthias Klugmann, Yazi D. Ke, Lars M. Ittner
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-15 (2017)
Excitotoxicity contributes to neuronal injury following stroke. Here the authors show that tau promotes excitotoxicity by a post-synaptic mechanism, involving site-specific control of ERK activation, in a mouse model of stroke.
Externí odkaz:
https://doaj.org/article/97fd15d6e4f1429dae0533cf6a3311e1
Autor:
Merryn Brettle, Holly Stefen, Aleksandra Djordjevic, Sandra Y. Y. Fok, Josephine W. Chan, Annika van Hummel, Julia van der Hoven, Magdalena Przybyla, Alexander Volkerling, Yazi D. Ke, Fabien Delerue, Lars M. Ittner, Thomas Fath
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 12 (2019)
Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with limited treatment and no cure. Mutations in profilin 1 were identified as a cause of familial ALS (fALS) in 2012. We investigated the functional impact of mutant prof
Externí odkaz:
https://doaj.org/article/3c0e270200b2444cb6a7451db65ce18f
Autor:
Dominik Fröhlich, Alexandra K. Suchowerska, Ziggy H.T. Spencer, Georg von Jonquieres, Claudia B. Klugmann, Andre Bongers, Fabien Delerue, Holly Stefen, Lars M. Ittner, Thomas Fath, Gary D. Housley, Matthias Klugmann
Publikováno v:
Neurobiology of Disease, Vol 97, Iss , Pp 24-35 (2017)
Background: The recently diagnosed leukodystrophy Hypomyelination with Brain stem and Spinal cord involvement and Leg spasticity (HBSL) is caused by mutations of the cytoplasmic aspartyl-tRNA synthetase gene DARS. The physiological role of DARS in tr
Externí odkaz:
https://doaj.org/article/39cbdf69bfe24fa787ad07522d5df957
Publikováno v:
Frontiers in Physiology, Vol 3 (2012)
Alzheimer's disease (AD) and frontotemporal lobar degeneration (FTLD) are complex human brain disorders that affect an increasing number of people worldwide. With the identification first of the proteins that aggregate in AD and FTLD brains and subse
Externí odkaz:
https://doaj.org/article/8d6f001c999f41e5927e9373246ac9d4