Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Lars M Steinmetz"'
Autor:
Alessandra Curioni-Fontecedro, Mitchell P Levesque, Roland Bruderer, Marco Tognetti, Lukas Reiter, Luca Raess, Yuehan Feng, Evelyn Ruth Lattmann, Julia Martinez Gomez, Valérie Lapaire, Stefanie Hiltbrunner, Lars M Steinmetz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/21970d288ce6425895e3028d91e583ab
Autor:
Daniel Schraivogel, Lars M Steinmetz
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 3, Pp n/a-n/a (2023)
Microscopy and fluorescence‐activated cell sorting (FACS) are two of the most important tools for single‐cell phenotyping in basic and biomedical research. Microscopy provides high‐resolution snapshots of cell morphology and the inner workings
Externí odkaz:
https://doaj.org/article/ffbefa27a0b54fa8abae856bb7f513d3
Autor:
Sergio Triana, Camila Metz‐Zumaran, Carlos Ramirez, Carmon Kee, Patricio Doldan, Mohammed Shahraz, Daniel Schraivogel, Andreas R Gschwind, Ashwini K Sharma, Lars M Steinmetz, Carl Herrmann, Theodore Alexandrov, Steeve Boulant, Megan L Stanifer
Publikováno v:
Molecular Systems Biology, Vol 17, Iss 4, Pp n/a-n/a (2021)
Abstract Exacerbated pro‐inflammatory immune response contributes to COVID‐19 pathology. However, despite the mounting evidence about SARS‐CoV‐2 infecting the human gut, little is known about the antiviral programs triggered in this organ. To
Externí odkaz:
https://doaj.org/article/17c5ff809f51416c977a1013d634db38
Autor:
Kristen L Wells, Corey N Miller, Andreas R Gschwind, Wu Wei, Jonah D Phipps, Mark S Anderson, Lars M Steinmetz
Publikováno v:
eLife, Vol 9 (2020)
Medullary thymic epithelial cells (mTECs) play a critical role in central immune tolerance by mediating negative selection of autoreactive T cells through the collective expression of the peripheral self-antigen compartment, including tissue-specific
Externí odkaz:
https://doaj.org/article/7e6e9a65e4af4c6ea418368160781fcd
Autor:
Sivan Kaminski Strauss, Dvir Schirman, Ghil Jona, Aaron N Brooks, Aditya M Kunjapur, Alex N Nguyen Ba, Alice Flint, Andras Solt, Andreas Mershin, Atray Dixit, Avihu H Yona, Bálint Csörgő, Bede Phillip Busby, Bianca P Hennig, Csaba Pál, Daniel Schraivogel, Daniel Schultz, David G Wernick, Deepa Agashe, Dikla Levi, Dmitry Zabezhinsky, Dor Russ, Ehud Sass, Einat Tamar, Elad Herz, Emmanuel D Levy, George M Church, Idan Yelin, Iftach Nachman, Jeffrey E Gerst, Joseph M Georgeson, Katarzyna P Adamala, Lars M Steinmetz, Marc Rübsam, Markus Ralser, Michael Klutstein, Michael M Desai, Nilima Walunjkar, Ning Yin, Noa Aharon Hefetz, Noah Jakimo, Olga Snitser, Omri Adini, Prashant Kumar, Rachel Soo Hoo Smith, Razi Zeidan, Ronen Hazan, Roni Rak, Roy Kishony, Shannon Johnson, Shira Nouriel, Sibylle C Vonesch, Simmie Foster, Tal Dagan, Tanita Wein, Thrasyvoulos Karydis, Timothy M Wannier, Timothy Stiles, Viridiana Olin-Sandoval, William F Mueller, Yinon M Bar-On, Orna Dahan, Yitzhak Pilpel
Publikováno v:
PLoS Biology, Vol 17, Iss 3, p e3000182 (2019)
In experimental evolution, scientists evolve organisms in the lab, typically by challenging them to new environmental conditions. How best to evolve a desired trait? Should the challenge be applied abruptly, gradually, periodically, sporadically? Sho
Externí odkaz:
https://doaj.org/article/bb9a50be8dcc4dc98274ddfdc59bba88
Autor:
Fernando Meza Gutierrez, Deniz Simsek, Arda Mizrak, Adam Deutschbauer, Hannes Braberg, Jeffrey Johnson, Jiewei Xu, Michael Shales, Michelle Nguyen, Raquel Tamse-Kuehn, Curt Palm, Lars M Steinmetz, Nevan J Krogan, David P Toczyski
Publikováno v:
eLife, Vol 7 (2018)
Although polyubiquitin chains linked through all lysines of ubiquitin exist, specific functions are well-established only for lysine-48 and lysine-63 linkages in Saccharomyces cerevisiae. To uncover pathways regulated by distinct linkages, genetic in
Externí odkaz:
https://doaj.org/article/f07665d4c7984c8e8770d5baaa41a25f
Autor:
Justin D Smith, Ulrich Schlecht, Weihong Xu, Sundari Suresh, Joe Horecka, Michael J Proctor, Raeka S Aiyar, Richard A O Bennett, Angela Chu, Yong Fuga Li, Kevin Roy, Ronald W Davis, Lars M Steinmetz, Richard W Hyman, Sasha F Levy, Robert P St.Onge
Publikováno v:
Molecular Systems Biology, Vol 13, Iss 2, Pp n/a-n/a (2017)
Abstract The low costs of array‐synthesized oligonucleotide libraries are empowering rapid advances in quantitative and synthetic biology. However, high synthesis error rates, uneven representation, and lack of access to individual oligonucleotides
Externí odkaz:
https://doaj.org/article/7ab84b1308cd4c04b4426d5c0715d2a2
Autor:
Lars M Steinmetz, Allan Jones
Publikováno v:
Molecular Systems Biology, Vol 12, Iss 4, Pp n/a-n/a (2016)
New fully integrated biosensors that monitor molecular and physiological parameters throughout our bodies are set to revolutionize medicine and personalized healthcare.
Externí odkaz:
https://doaj.org/article/2d2b1008bd18443597a2667dd1baa74d
Autor:
Rebecca K Holmes, Alex C Tuck, Chenchen Zhu, Hywel R Dunn-Davies, Grzegorz Kudla, Sandra Clauder-Munster, Sander Granneman, Lars M Steinmetz, Christine Guthrie, David Tollervey
Publikováno v:
PLoS Genetics, Vol 11, Iss 12, p e1005735 (2015)
Yeast Npl3 is a highly abundant, nuclear-cytoplasmic shuttling, RNA-binding protein, related to metazoan SR proteins. Reported functions of Npl3 include transcription elongation, splicing and RNA 3' end processing. We used UV crosslinking and analysi
Externí odkaz:
https://doaj.org/article/e24c2b5e4ec94d2a8f9c71541404b6f0
Autor:
Saumya Gupta, Aparna Radhakrishnan, Pandu Raharja-Liu, Gen Lin, Lars M Steinmetz, Julien Gagneur, Himanshu Sinha
Publikováno v:
PLoS Genetics, Vol 11, Iss 6, p e1005195 (2015)
Even with identification of multiple causal genetic variants for common human diseases, understanding the molecular processes mediating the causal variants' effect on the disease remains a challenge. This understanding is crucial for the development
Externí odkaz:
https://doaj.org/article/883680140d11499b816c36f238473bde