Zobrazeno 1 - 10
of 293
pro vyhledávání: '"Lars M, Steinmetz"'
Autor:
Gernot Neumayer, Jessica L. Torkelson, Shengdi Li, Kelly McCarthy, Hanson H. Zhen, Madhuri Vangipuram, Marius M. Mader, Gulilat Gebeyehu, Taysir M. Jaouni, Joanna Jacków-Malinowska, Avina Rami, Corey Hansen, Zongyou Guo, Sadhana Gaddam, Keri M. Tate, Alberto Pappalardo, Lingjie Li, Grace M. Chow, Kevin R. Roy, Thuylinh Michelle Nguyen, Koji Tanabe, Patrick S. McGrath, Amber Cramer, Anna Bruckner, Ganna Bilousova, Dennis Roop, Jean Y. Tang, Angela Christiano, Lars M. Steinmetz, Marius Wernig, Anthony E. Oro
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract We present Dystrophic Epidermolysis Bullosa Cell Therapy (DEBCT), a scalable platform producing autologous organotypic iPS cell-derived induced skin composite (iSC) grafts for definitive treatment. Clinical-grade manufacturing integrates CRI
Externí odkaz:
https://doaj.org/article/beaa5273b9ae4861a2bf161a05a28b1a
Autor:
Joseph J. Hale, Takeshi Matsui, Ilan Goldstein, Martin N. Mullis, Kevin R. Roy, Christopher Ne Ville, Darach Miller, Charley Wang, Trevor Reynolds, Lars M. Steinmetz, Sasha F. Levy, Ian M. Ehrenreich
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Interactions between genetic perturbations and segregating loci can cause perturbations to show different phenotypic effects across genetically distinct individuals. To study these interactions on a genome scale in many individuals, we used
Externí odkaz:
https://doaj.org/article/ee32dc78706e4b53b16fa9b04f944fc0
Autor:
Ashutosh Pandey, Antonio Galeone, Seung Yeop Han, Benjamin A. Story, Gaia Consonni, William F. Mueller, Lars M. Steinmetz, Thomas Vaccari, Hamed Jafar-Nejad
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Intestinal barrier dysfunction leads to inflammation and associated metabolic changes. However, the relative impact of gut bacteria versus non-bacterial insults on animal health in the context of barrier dysfunction is not well understood. H
Externí odkaz:
https://doaj.org/article/fc75a5d2d921427790e61a8613dba176
Autor:
Julia Kornienko, Marta Rodríguez-Martínez, Kai Fenzl, Florian Hinze, Daniel Schraivogel, Markus Grosch, Brigit Tunaj, Dominik Lindenhofer, Laura Schraft, Moritz Kueblbeck, Eric Smith, Chad Mao, Emily Brown, Anjali Owens, Ardan M. Saguner, Benjamin Meder, Victoria Parikh, Michael Gotthardt, Lars M. Steinmetz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich domain (RS-domain). Such mutations can cause defective splic
Externí odkaz:
https://doaj.org/article/22609fd3b5c8440ebce2789206b89798
Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy
Autor:
Markus Grosch, Laura Schraft, Adrian Chan, Leonie Küchenhoff, Kleopatra Rapti, Anne-Maud Ferreira, Julia Kornienko, Shengdi Li, Michael H. Radke, Chiara Krämer, Sandra Clauder-Münster, Emerald Perlas, Johannes Backs, Michael Gotthardt, Christoph Dieterich, Maarten M. G. van den Hoogenhof, Dirk Grimm, Lars M. Steinmetz
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Abstract Dilated cardiomyopathy is the second most common cause for heart failure with no cure except a high-risk heart transplantation. Approximately 30% of patients harbor heritable mutations which are amenable to CRISPR-based gene therapy. However
Externí odkaz:
https://doaj.org/article/287d1894c5f548b689b58cdf403063c5
Autor:
Sören Lammers, Victor Barrera, Philip Brennecke, Corey Miller, Joon Yoon, Jared Balolong, Mark S. Anderson, Shannan Ho Sui, Lars M. Steinmetz, Ulrich H. von Andrian, Kristin Rattay
Publikováno v:
Frontiers in Immunology, Vol 14 (2024)
Thymic epithelial cells are indispensable for T cell maturation and selection and the induction of central immune tolerance. The self-peptide repertoire expressed by medullary thymic epithelial cells is in part regulated by the transcriptional regula
Externí odkaz:
https://doaj.org/article/2a453b20f1314e24b105a537b5bc3235
Autor:
Alessandra Curioni-Fontecedro, Mitchell P Levesque, Roland Bruderer, Marco Tognetti, Lukas Reiter, Luca Raess, Yuehan Feng, Evelyn Ruth Lattmann, Julia Martinez Gomez, Valérie Lapaire, Stefanie Hiltbrunner, Lars M Steinmetz
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/21970d288ce6425895e3028d91e583ab
Autor:
Daniel Schraivogel, Lars M Steinmetz
Publikováno v:
Molecular Systems Biology, Vol 19, Iss 3, Pp 1-4 (2023)
Abstract Microscopy and fluorescence‐activated cell sorting (FACS) are two of the most important tools for single‐cell phenotyping in basic and biomedical research. Microscopy provides high‐resolution snapshots of cell morphology and the inner
Externí odkaz:
https://doaj.org/article/ffbefa27a0b54fa8abae856bb7f513d3
Autor:
Bingnan Li, Patrice Zeis, Yujie Zhang, Alisa Alekseenko, Eliska Fürst, Yerma Pareja Sanchez, Gen Lin, Manu M. Tekkedil, Ilaria Piazza, Lars M. Steinmetz, Vicent Pelechano
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-17 (2023)
Transcriptional memory is key for cellular adaptation. Here the authors show that differences in mRNA stability and mRNA degradation machinery between naïve and primed cells facilitate faster gene expression response to repeated stimuli.
Externí odkaz:
https://doaj.org/article/07c6c17a87b14297806ea44f76865958
NIMA-related kinase 9 regulates the phosphorylation of the essential myosin light chain in the heart
Autor:
Marion Müller, Rose Eghbalian, Jes-Niels Boeckel, Karen S. Frese, Jan Haas, Elham Kayvanpour, Farbod Sedaghat-Hamedani, Maximilian K. Lackner, Oguz F. Tugrul, Thomas Ruppert, Rewati Tappu, Diana Martins Bordalo, Jasmin M. Kneuer, Annika Piekarek, Sabine Herch, Sarah Schudy, Andreas Keller, Nadja Grammes, Cornelius Bischof, Anna Klinke, Margarida Cardoso-Moreira, Henrik Kaessmann, Hugo A. Katus, Norbert Frey, Lars M. Steinmetz, Benjamin Meder
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Phosphorylation of the essential myosin light chain (ELC) influence actin-myosin crossbridge cycling in the heart. Here, the authors show upregulated ELC-phosphorylation in systolic heart failure and identify NIMArelated kinase 9 to bind to ELC media
Externí odkaz:
https://doaj.org/article/bdd3c98ae2ae446c8307d5af259ac8e7