Zobrazeno 1 - 10
of 22
pro vyhledávání: '"Lars La Cour Poulsen"'
Autor:
Olav Sundnes, William Ottestad, Camilla Schjalm, Peter Lundbäck, Lars la Cour Poulsen, Tom Eirik Mollnes, Guttorm Haraldsen, Torsten Eken
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-10 (2021)
Abstract Background Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple t
Externí odkaz:
https://doaj.org/article/f12796fc20414a50b606752fc86cd814
Autor:
Kerstin Rohde, Maria Keller, Lars la Cour Poulsen, Torunn Rønningen, Michael Stumvoll, Anke Tönjes, Peter Kovacs, Annette Horstmann, Arno Villringer, Matthias Blüher, Yvonne Böttcher
Publikováno v:
EBioMedicine, Vol 44, Iss , Pp 476-488 (2019)
Background: In brain, CREB-regulated transcription co-activator 1 (CRTC1) is involved in metabolic dysregulation. In humans a SNP in CRTC1 was associated to body fat percentage and two SNPs affected RNA Pol II binding and chromatin structure, implyin
Externí odkaz:
https://doaj.org/article/d211e75101e7400f87ee4c2aca3117d1
Publikováno v:
BMJ Open Diabetes Research & Care, Vol 8, Iss 1 (2020)
IntroductionRegional fat distribution strongly relates to metabolic comorbidities. We identified the DNA repair genes H2AX and HMGB1 to be differentially expressed between human subcutaneous (SAT) and omental visceral adipose tissue (OVAT) depots. As
Externí odkaz:
https://doaj.org/article/efaab61169744a7799f51ddf11c3f891
Autor:
Jonas Aakre Wik, Peter Lundbäck, Lars la Cour Poulsen, Guttorm Haraldsen, Bjørn Steen Skålhegg, Johanna Hol
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229395 (2020)
Inhibition of the key glycolytic activator 6-phosphofructokinase 2/fructose-2,6-bisphosphatase-3 (PFKFB3) by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) strongly attenuates pathological angiogenesis in cancer and inflammation. In addition to
Externí odkaz:
https://doaj.org/article/0408175e543a48f4a3261012f19cb1d2
Autor:
Søren Fisker Schmidt, Jesper Grud Skat Madsen, Kari Østerli Frafjord, Lars la Cour Poulsen, Sofia Salö, Michael Boergesen, Anne Loft, Bjørk Ditlev Larsen, Maria Stahl Madsen, Jens Juul Holst, Pierre Maechler, Louise Torp Dalgaard, Susanne Mandrup
Publikováno v:
Cell Reports, Vol 16, Iss 9, Pp 2359-2372 (2016)
Glucose is an important inducer of insulin secretion, but it also stimulates long-term adaptive changes in gene expression that can either promote or antagonize the proliferative potential and function of β cells. Here, we have generated time-resolv
Externí odkaz:
https://doaj.org/article/2b83c11013944fa69bbfc6975a444fc9
Autor:
Rasmus Siersbæk, Atefeh Rabiee, Ronni Nielsen, Simone Sidoli, Sofie Traynor, Anne Loft, Lars La Cour Poulsen, Adelina Rogowska-Wrzesinska, Ole N. Jensen, Susanne Mandrup
Publikováno v:
Cell Reports, Vol 7, Iss 5, Pp 1443-1455 (2014)
It is becoming increasingly clear that transcription factors operate in complex networks through thousands of genomic binding sites, many of which bind several transcription factors. However, the extent and mechanisms of crosstalk between transcripti
Externí odkaz:
https://doaj.org/article/b6ff40225eff480984ded561723aad8f
Autor:
Anke Tönjes, Peter Kovacs, Matthias Blüher, Annette Horstmann, Torunn Rønningen, Yvonne Böttcher, Kerstin Rohde, Arno Villringer, Michael Stumvoll, Lars la Cour Poulsen, Maria Keller
Publikováno v:
EBioMedicine
Background In brain, CREB-regulated transcription co-activator 1 (CRTC1) is involved in metabolic dysregulation. In humans a SNP in CRTC1 was associated to body fat percentage and two SNPs affected RNA Pol II binding and chromatin structure, implying
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2f5394965abf693776451ca68759333
https://doi.org/10.1016/j.ebiom.2019.05.050
https://doi.org/10.1016/j.ebiom.2019.05.050
Autor:
Lars La Cour Poulsen, Olav Sundnes, Torsten Eken, William Ottestad, Camilla Schjalm, Tom Eirik Mollnes, Guttorm Haraldsen, Peter Lundbäck
Publikováno v:
Molecular Medicine, Vol 27, Iss 1, Pp 1-10 (2021)
Molecular medicine (Cambridge, Mass. Print)
Molecular Medicine
Molecular medicine (Cambridge, Mass. Print)
Molecular Medicine
Background Alarmins are considered proximal mediators of the immune response after tissue injury. Understanding their biology could pave the way for development of new therapeutic targets and biomarkers in human disease, including multiple trauma. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26c96a50d0e20f74e7a2c237d5def121
https://hdl.handle.net/10037/21581
https://hdl.handle.net/10037/21581
Autor:
Lars La Cour Poulsen, Guttorm Haraldsen, Johanna Hol, Peter Lundbäck, Bjørn Steen Skålhegg, Jonas Aakre Wik
Publikováno v:
PLoS ONE, Vol 15, Iss 3, p e0229395 (2020)
PLoS ONE
PLoS ONE
Inhibition of the key glycolytic activator 6-phosphofructokinase 2/fructose-2,6-bisphosphatase-3 (PFKFB3) by 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one (3PO) strongly attenuates pathological angiogenesis in cancer and inflammation. In addition to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5031c1bf4fe430ab3df51d24374ac763
http://hdl.handle.net/10852/82645
http://hdl.handle.net/10852/82645
Autor:
Rui Benedito, Kim S. Midwood, Monika Szymanska, Ralf H. Adams, Tor Espen Stav-Noraas, Christian W. Siebel, Eirik Sundlisæter, Anastasia Renzi, Helge Scott, Monika Kasprzycka, Manuel Ehling, Johanna Hol, Lars La Cour Poulsen, Espen S. Baekkevold, Olav Sundnes, Reidunn J Edelmann, Rodrigo Diéguez-Hurtado, Philippe Collas, Akshay Shah, Guttorm Haraldsen, Stig Krüger, Junbai Wang
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 38:854-869
Objective— Endothelial upregulation of adhesion molecules serves to recruit leukocytes to inflammatory sites and appears to be promoted by NOTCH1; however, current models based on interactions between active NOTCH1 and NF-κB components cannot expl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4adc5183a15bfb1b98f5947eb610064d
https://doi.org/10.1161/atvbaha.117.310388
https://doi.org/10.1161/atvbaha.117.310388