Zobrazeno 1 - 10 of 12 pro vyhledávání: '"Lars Kissau"'
1
Identification of mono- and bisubstrate inhibitors of protein farnesyltransferase and inducers of apoptosis from a pepticinnamin E library
Autor: Jürgen Kuhlmann, Michael Thutewohl, Thorsten Nowak, Michael Bate, Ionna-Maria Karaguni, Lars Kissau, Oliver Müller, Boriana Popkirova, Herbert Waldmann
Publikováno v: Bioorganic & Medicinal Chemistry. 11:2617-2626
A library of 51 analogues of the naturally occurring protein farnesyltransferase inhibitor pepticinnamin E was investigated biologically. Several compounds with pronounced inhibitory activity were discovered with the lowest IC 50 value reaching 1 μM
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b569638b1e14e7578c563c870a387893
https://doi.org/10.1016/s0968-0896(03)00160-3
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6
Synthesis of GTP-derived Ras ligands
Autor: Lars Kissau, Oliver Daumke, Herbert Waldmann, Robert Gail, Alfred Wittinghofer, Courtney Aldrich, Laurent Soulère
Publikováno v: Chembiochem : a European journal of chemical biology. 5(10)
A practical and convenient method for the synthesis of acid- and base-sensitive GTP analogues carrying a further substituent at the terminal phosphate has been developed. Key to the successful synthesis of these potential ligands of the Ras protein i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b45161db5086f6492cd4a281fe85b4cd
https://pubmed.ncbi.nlm.nih.gov/15457534
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7
Development of natural product-derived receptor tyrosine kinase inhibitors based on conservation of protein domain fold
Autor: Lars Kissau, Ralph Mazitschek, Petra Stahl, Herbert Waldmann, Athannasios Giannis
Publikováno v: Journal of medicinal chemistry. 46(14)
Receptor tyrosine kinases (RTKs) such as Tie-2, IGF1R, Her-2/Neu, EGFR, and VEGFR1-3 play crucial roles in the control of cell growth and differentiation. Inhibition of such RTKs has become a major focus of current anticancer drug development, and th
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8477aadde2c1edf5fc40af44ab8ef740
https://pubmed.ncbi.nlm.nih.gov/12825933
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9
Total synthesis and biological evaluation of the nakijiquinones
Autor: Lars Kissau, Ralph Mazitschek, Pascal Furet, Petra Stahl, Herbert Waldmann, Athanassios Giannis, Axel Huwe
Publikováno v: Journal of the American Chemical Society. 123(47)
The Her-2/Neu receptor tyrosine kinase is vastly overexpressed in about 30% of primary breast, ovary, and gastric carcinomas. The nakijiquinones are the only naturally occurring inhibitors of this important oncogene, and structural analogues of the n
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63650e7f9db4cab4a9e64804204ed46a
https://pubmed.ncbi.nlm.nih.gov/11716712
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