Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lars Ketscher"'
Autor:
Leandro Z. Agudelo, Duarte M. S. Ferreira, Shamim Dadvar, Igor Cervenka, Lars Ketscher, Manizheh Izadi, Liu Zhengye, Regula Furrer, Christoph Handschin, Tomas Venckunas, Marius Brazaitis, Sigitas Kamandulis, Johanna T. Lanner, Jorge L. Ruas
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
PGC-1α is activated by exercise and promotes resistance to fatigue in muscles. Here, the authors show that PGC-1α activates the malate-aspartate shuttle, and allows muscle to utilise kynurenine, leading to more efficient glucose oxidation and mitoc
Externí odkaz:
https://doaj.org/article/4a97fef9ea204ae2827332216ca511a8
Autor:
Irem Bayindir‐Buchhalter, Gretchen Wolff, Sarah Lerch, Tjeerd Sijmonsma, Maximilian Schuster, Jan Gronych, Adrian T Billeter, Rohollah Babaei, Damir Krunic, Lars Ketscher, Nadine Spielmann, Martin Hrabe de Angelis, Jorge L Ruas, Beat P Müller‐Stich, Mathias Heikenwalder, Peter Lichter, Stephan Herzig, Alexandros Vegiopoulos
Publikováno v:
EMBO Molecular Medicine, Vol 10, Iss 8, Pp 1-18 (2018)
Abstract Most antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. Pharmacological targeting of adipose tissue through the nuclear receptor PPARg, as
Externí odkaz:
https://doaj.org/article/a4f7620a706d40c1b743c16d6f4e5f05
Autor:
Christoph Handschin, Marius Brazaitis, Tomas Venckunas, Igor Cervenka, Shamim Dadvar, Duarte M. S. Ferreira, Regula Furrer, Liu Zhengye, Lars Ketscher, Jorge L. Ruas, Johanna T. Lanner, Leandro Z. Agudelo, Manizheh Izadi, Sigitas Kamandulis
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The coactivator PGC-1α1 is activated by exercise training in skeletal muscle and promotes fatigue-resistance. In exercised muscle, PGC-1α1 enhances the expression of kynurenine aminotransferases (Kats), which convert kynurenine into kynurenic acid.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::983debdc6c07968c54ef411cb494b72f
http://link.springer.com/article/10.1038/s41467-019-10712-0
http://link.springer.com/article/10.1038/s41467-019-10712-0
Autor:
Nadine Spielmann, Rohollah Babaei, Adrian T. Billeter, Lars Ketscher, Jorge L. Ruas, Tjeerd P. Sijmonsma, Gretchen Wolff, Jan Gronych, Martin Hrabé de Angelis, Alexandros Vegiopoulos, Mathias Heikenwalder, Damir Krunic, Maximilian Schuster, Stephan Herzig, Irem Bayindir-Buchhalter, Beat P. Müller-Stich, Peter Lichter, Sarah Lerch
Publikováno v:
EMBO Molecular Medicine
EMBO Mol. Med. 10:e8613 (2018)
EMBO Molecular Medicine, Vol 10, Iss 8, Pp n/a-n/a (2018)
EMBO Mol. Med. 10:e8613 (2018)
EMBO Molecular Medicine, Vol 10, Iss 8, Pp n/a-n/a (2018)
Most antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. Pharmacological targeting of adipose tissue through the nuclear receptor PPARg, as exemplif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d53e152b5efc2326881c2eb76d63421
https://doi.org/10.15252/emmm.201708613
https://doi.org/10.15252/emmm.201708613
Autor:
Philipp Bleienheuft, Konstantinos Savvatis, Wolfgang Poller, Lars Ketscher, Nicola L. Diny, Dorota Respondek, Carsten Tschöpe, Antje Voigt, Anika Lindner, Elisa Opitz, Nadine Althof, Martina Sauter, Anna Rahnefeld, Karin Klingel, Anett Schuermann, Klaus-Peter Knobeloch, Ulrike Seifert
Publikováno v:
Circulation. 130:1589-1600
Background— Common causative agents in the development of inflammatory cardiomyopathy include cardiotropic viruses such as coxsackievirus B3 (CVB3). Here, we investigated the role of the ubiquitin-like modifier interferon-stimulated gene of 15 kDa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c55f38f52950d309c51c8df1dfd07e1
https://doi.org/10.1161/circulationaha.114.009847
https://doi.org/10.1161/circulationaha.114.009847
Autor:
Anja Basters, Lars Ketscher, Eberhard Krause, Huib Ovaa, Paul P. Geurink, Farid El Oualid, Günter Fritz, Marco S. Casutt, Klaus-Peter Knobeloch
Publikováno v:
FEBS Journal. 281:1918-1928
Protein modification by interferon-stimulated gene 15 (ISG15), an ubiquitin-like modifier, affects multiple cellular functions and represents one of the major antiviral effector systems. Covalent linkage of ISG15 to proteins was previously reported t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56d5413fda7cfc2fce119e253c3e51f8
https://doi.org/10.1111/febs.12754
https://doi.org/10.1111/febs.12754
Autor:
Carmen Kropp-Goerkis, Lars Ketscher, Christian Bergsdorf, Irene Kaehler, Karsten Parczyk, Benjamin Bader, Ulf Boemer
Publikováno v:
ASSAY and Drug Development Technologies. 6:39-53
Compared to biochemical high-throughput screening (HTS) assays, cell-based functional assays are generally thought to be more time consuming and complex because of additional efforts for running continuous cell cultures as well as the numerous assay
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::295a7fa83ee0ead26ca4b54fb0408c34
https://doi.org/10.1089/adt.2007.108
https://doi.org/10.1089/adt.2007.108
Autor:
Lars Ketscher, Klaus-Peter Knobeloch
Publikováno v:
Cytokine. 76(2)
Posttranslational protein modification by ISG15 plays an important role in antiviral defense. We selectively inactivated the ISG15 isopeptidase activity of USP18 in mice. Increased ISGylation was accompanied by enhanced viral resistance without causi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2923c0608be91a501234fc0b56fc8b15
https://pubmed.ncbi.nlm.nih.gov/25805508
https://pubmed.ncbi.nlm.nih.gov/25805508
Autor:
Annika Hausmann, Tobias Goldmann, Susana Guerra, Klaus-Peter Knobeloch, Marco Prinz, Anja Basters, David J. Morales, Ronald Naumann, Andrew Pekosz, Deborah J. Lenschow, Lars Ketscher, Olaf Utermöhlen, Ronny Hannß
Publikováno v:
Biblos-e Archivo. Repositorio Institucional de la UAM
instname
instname
Protein modification by the ubiquitin-like protein ISG15 is an interferon (IFN) effector system, which plays a major role in antiviral defense. ISG15 modification is counteracted by the isopeptidase USP18, a major negative regulator of IFN signaling,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b6e2ba961aac633ff9c662ad9d4d17ae
http://hdl.handle.net/10486/672352
http://hdl.handle.net/10486/672352
Autor:
Katrin Kierdorf, Anja Basters, Danielle Malo, Grazia M.S. Mancini, Knut Biber, Tuan Leng Tay, Tobias Goldmann, Ori Staszewski, Jens Timmer, Doron Merkler, Roland Lang, Kathrin Frenzel, Marco Prinz, Günter Fritz, Jenni Raasch, Lars Ketscher, Mathias Heikenwalder, Nicolas Zeller, Klaus-Peter Knobeloch, Alena Spiess, Stefanie M. Brendecke, Clemens Kreutz, Thomas Blank
Publikováno v:
EMBO Journal, Vol. 34, No 12 (2015) pp. 1612-29
EMBO Journal, 34(12), 1612-1629. Wiley-Blackwell
The EMBO Journal, 34(12), 1612-1629. Wiley
EMBO J. 34, 1612-1629 (2015)
The EMBO journal
EMBO Journal, 34(12), 1612-1629. Wiley-Blackwell
The EMBO Journal, 34(12), 1612-1629. Wiley
EMBO J. 34, 1612-1629 (2015)
The EMBO journal
Microglia are tissue macrophages of the central nervous system (CNS) that control tissue homeostasis. Microglia dysregulation is thought to be causal for a group of neuropsychiatric, neurodegenerative and neuroinflammatory diseases, called "microglio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9de6c686980984cbeee3063628649e47
https://archive-ouverte.unige.ch/unige:73892
https://archive-ouverte.unige.ch/unige:73892