Zobrazeno 1 - 10
of 128
pro vyhledávání: '"Lars J. Jensen"'
Autor:
Ulises H. Guzman, Henriette Aksnes, Rasmus Ree, Nicolai Krogh, Magnus E. Jakobsson, Lars J. Jensen, Thomas Arnesen, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract Protein N-terminal (Nt) acetylation is one of the most abundant modifications in eukaryotes, covering ~50-80 % of the proteome, depending on species. Cells with defective Nt-acetylation display a wide array of phenotypes such as impaired gro
Externí odkaz:
https://doaj.org/article/6c2af7ea88d24f7caa6388df7933b1f4
Autor:
Reza Yarani, Oana Palasca, Nadezhda T. Doncheva, Christian Anthon, Bartosz Pilecki, Cecilie A. S. Svane, Aashiq H. Mirza, Thomas Litman, Uffe Holmskov, Claus H. Bang-Berthelsen, Mogens Vilien, Lars J. Jensen, Jan Gorodkin, Flemming Pociot
Publikováno v:
Frontiers in Molecular Biosciences, Vol 9 (2023)
Background: Ulcerative colitis (UC) is a disorder with unknown etiology, and animal models play an essential role in studying its molecular pathophysiology. Here, we aim to identify common conserved pathological UC-related gene expression signatures
Externí odkaz:
https://doaj.org/article/715c5209dfe143fea179b0e716c6022a
Autor:
Adrian S. Geissler, Line D. Poulsen, Nadezhda T. Doncheva, Christian Anthon, Stefan E. Seemann, Enrique González-Tortuero, Anne Breüner, Lars J. Jensen, Carsten Hjort, Jeppe Vinther, Jan Gorodkin
Publikováno v:
Frontiers in Microbiology, Vol 13 (2022)
The production of the alpha-amylase (AMY) enzyme in Bacillus subtilis at a high rate leads to the accumulation of unfolded AMY, which causes secretion stress. The over-expression of the PrsA chaperone aids enzyme folding and reduces stress. To identi
Externí odkaz:
https://doaj.org/article/a60d2c584eda4fc5adb17a7740bf7e63
Autor:
Nora Linscheid, Alberto Santos, Pi Camilla Poulsen, Robert W Mills, Kirstine Calloe, Ulrike Leurs, Johan Z Ye, Christian Stolte, Morten B Thomsen, Bo H Bentzen, Pia R Lundegaard, Morten S Olesen, Lars J Jensen, Jesper V Olsen, Alicia Lundby
Publikováno v:
PLoS Biology, Vol 19, Iss 4, p e3001144 (2021)
Delineating human cardiac pathologies and their basic molecular mechanisms relies on research conducted in model organisms. Yet translating findings from preclinical models to humans present a significant challenge, in part due to differences in card
Externí odkaz:
https://doaj.org/article/803278d7d2314c97a5198af5d5449f9c
Autor:
Rosa R. Jersie-Christensen, Liam T. Lanigan, David Lyon, Meaghan Mackie, Daniel Belstrøm, Christian D. Kelstrup, Anna K. Fotakis, Eske Willerslev, Niels Lynnerup, Lars J. Jensen, Enrico Cappellini, Jesper V. Olsen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-12 (2018)
Mineralized plaque, or dental calculus, is a valuable reservoir of the ancient oral microbiome. Here, the authors use quantitative metaproteomics to analyze the dental calculus of 21 individuals from a medieval cemetery, identifying human and microbi
Externí odkaz:
https://doaj.org/article/4a05ddd442974d9dbdfa9bc7a6259398
Autor:
Ivo A. Hendriks, David Lyon, Dan Su, Niels H. Skotte, Jeremy A. Daniel, Lars J. Jensen, Michael L. Nielsen
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Proteomics is a powerful method to study protein SUMOylation, but system-wide insights into endogenous SUMO2/3 modification events are still sparse. Here, the authors develop a more sensitive SUMO proteomics approach, providing detailed maps of endog
Externí odkaz:
https://doaj.org/article/f1a95d5fa715451a8a9764153f666d48
Autor:
Chiara Francavilla, Michela Lupia, Kalliopi Tsafou, Alessandra Villa, Katarzyna Kowalczyk, Rosa Rakownikow Jersie-Christensen, Giovanni Bertalot, Stefano Confalonieri, Søren Brunak, Lars J. Jensen, Ugo Cavallaro, Jesper V. Olsen
Publikováno v:
Cell Reports, Vol 18, Iss 13, Pp 3242-3256 (2017)
Our understanding of the molecular determinants of cancer is still inadequate because of cancer heterogeneity. Here, using epithelial ovarian cancer (EOC) as a model system, we analyzed a minute amount of patient-derived epithelial cells from either
Externí odkaz:
https://doaj.org/article/b22efed567f248cf8c6df37c93643339
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
The study of molecular host–parasite interactions is essential to understand parasitic infection and adaptation within the host system. As well, prevention and treatment of infectious diseases require a clear understanding of the molecular crosstal
Externí odkaz:
https://doaj.org/article/077c9a89f466482cb322b3c63c90afcc
Autor:
Jesper V. Olsen, Lars J. Jensen, Kim Theilgaard-Mönch, Stephen C. Blacklow, Vidyasiri Vemulapalli, Kristian Reckzeh, Ilaria Piga, Marie Locard-Paulet, Giulia Franciosa, Anamarija Pfeiffer
Supplementary Data from Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD–Driven AML
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e44e4fc3515e4df0e347ed1a54c643c
https://doi.org/10.1158/0008-5472.22430284
https://doi.org/10.1158/0008-5472.22430284
Autor:
Jesper V. Olsen, Lars J. Jensen, Kim Theilgaard-Mönch, Stephen C. Blacklow, Vidyasiri Vemulapalli, Kristian Reckzeh, Ilaria Piga, Marie Locard-Paulet, Giulia Franciosa, Anamarija Pfeiffer
The protein tyrosine phosphatase SHP2 is crucial for oncogenic transformation of acute myeloid leukemia (AML) cells expressing mutated receptor tyrosine kinases. SHP2 is required for full RAS-ERK activation to promote cell proliferation and survival
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::78e5a2bf99c8efb8cfecfca5df859849
https://doi.org/10.1158/0008-5472.c.6513577.v1
https://doi.org/10.1158/0008-5472.c.6513577.v1