Zobrazeno 1 - 10 of 18 pro vyhledávání: '"Lars J, Hansen"'
1
Akademický článek
Mapping RANKL- and OPG-expressing cells in bone tissue: the bone surface cells as activators of osteoclastogenesis and promoters of the denosumab rebound effect
Autor: Bilal M. El-Masri, Christina M. Andreasen, Kaja S. Laursen, Viktoria B. Kofod, Xenia G. Dahl, Malene H. Nielsen, Jesper S. Thomsen, Annemarie Brüel, Mads S. Sørensen, Lars J. Hansen, Albert S. Kim, Victoria E. Taylor, Caitlyn Massarotti, Michelle M. McDonald, Xiaomeng You, Julia F. Charles, Jean-Marie Delaisse, Thomas L. Andersen
Publikováno v: Bone Research, Vol 12, Iss 1, Pp 1-21 (2024)
Abstract Denosumab is a monoclonal anti-RANKL antibody that inhibits bone resorption, increases bone mass, and reduces fracture risk. Denosumab discontinuation causes an extensive wave of rebound resorption, but the cellular mechanisms remain poorly
Externí odkaz: https://doaj.org/article/debb0e5b2c6f4fcd819cdbe0ec3b3e1c
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2
Akademický článek
Urinary markers of nucleic acid oxidation and cancer in type 2 diabetes
Autor: Kasper Broedbaek, Volkert Siersma, Trine Henriksen, Allan Weimann, Morten Petersen, Jon T. Andersen, Espen Jimenez-Solem, Lars J. Hansen, Jan Erik Henriksen, Steen J. Bonnema, Niels de Fine Olivarius, Søren Friis, Henrik E. Poulsen
Publikováno v: Redox Biology, Vol 4, Iss C, Pp 34-39 (2015)
Aims/hypothesis: We investigated whether urinary markers of nucleic acid oxidation are associated with an increased risk of cancer in type 2 diabetes patients. Methods: Urine samples from 1381 newly diagnosed diabetes patients were assayed for the ox
Externí odkaz: https://doaj.org/article/c40ff9737d4e4878950f45fe74be1b85
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3
Structured personal care of type 2 diabetes: a 19 year follow-up of the study Diabetes Care in General Practice (DCGP)
Autor: N. de Fine Olivarius, Henning Beck-Nielsen, Volkert Siersma, Lars J. Hansen
Publikováno v: Hansen, L J, Siersma, V D, Beck-Nielsen, H & de Fine Olivarius, N 2013, ' Structured personal care of type 2 diabetes : a 19 year follow-up of the study Diabetes Care in General Practice (DCGP) ', Diabetologia, vol. 56, no. 6, pp. 1243-1253 . https://doi.org/10.1007/s00125-013-2893-1
Aims/hypothesis: This study is a 19 year observational follow-up of a pragmatic open multicentre cluster-randomised controlled trial of 6 years of structured personal diabetes care starting from diagnosis. Methods: A total of 1,381 patients aged ≥4
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8388f29b2f87944a7611031233498ccc
https://doi.org/10.1007/s00125-013-2893-1
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4
Association Between Urinary Markers of Nucleic Acid Oxidation and Mortality in Type 2 Diabetes
Autor: Morten Petersen, Jan Erik Henriksen, Henrik E. Poulsen, Niels de Fine Olivarius, Lars J. Hansen, Kasper Broedbaek, Allan Weimann, Jon Trærup Andersen, Steen Joop Bonnema, Trine Henriksen, Volkert Siersma, Espen Jimenez-Solem
Publikováno v: Diabetes Care. 36:669-676
OBJECTIVE We recently showed that RNA oxidation, estimated by urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo), independently predicted mortality in a cohort of 1,381 treatment-naive patients with newly diagnosed type 2 diabetes. In the pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4d6944ce1a454e9c4070354956f29682
https://doi.org/10.2337/dc12-0998
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6
Patients Newly Diagnosed with Clinical Type 2 Diabetes during Oral Glucocorticoid Treatment and Observed for 14 Years: All-Cause Mortality and Clinical Developments
Autor: Volkert Siersma, Thomas Drivsholm, Niels de Fine Olivarius, Beatrice Dyring-Andersen, Jan Erik Henriksen, Lars J. Hansen
Publikováno v: Basic & Clinical Pharmacology & Toxicology. 108:285-288
Chronic exposure to glucocorticoids (GCs) has many side effects including glucose intolerance and diabetes and may accelerate the occurrence of cardiovascular disease and increase mortality. We studied the 14-year clinical development of diabetes in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::50bc6864337c0ae62865fb3bf1075336
https://doi.org/10.1111/j.1742-7843.2010.00650.x
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7
Encouraging GPs to undertake screening and a brief intervention in order to reduce problem drinking: a randomized controlled trial
Autor: Sverre Malm Barfod, Niels de Fine Olivarius, Lars J. Hansen, Anders Beich
Publikováno v: University of Copenhagen
BACKGROUND: GPs are in a key position to screen the population for problem drinking. However, so far this has not been extensively undertaken in general practice. Thus, studies relating to encouraging the undertaking in general practice of screening
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d61b011a658f531f8eaa600b0855728
https://doi.org/10.1093/fampra/16.6.551
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8
Association between urinary markers of nucleic acid oxidation and mortality in type 2 diabetes: a population-based cohort study
Autor: Kasper, Broedbaek, Volkert, Siersma, Trine, Henriksen, Allan, Weimann, Morten, Petersen, Jon T, Andersen, Espen, Jimenez-Solem, Lars J, Hansen, Jan Erik, Henriksen, Steen J, Bonnema, Niels, de Fine Olivarius, Henrik E, Poulsen
Publikováno v: Diabetes Care
OBJECTIVE We recently showed that RNA oxidation, estimated by urinary excretion of 8-oxo-7,8-dihydroguanosine (8-oxoGuo), independently predicted mortality in a cohort of 1,381 treatment-naive patients with newly diagnosed type 2 diabetes. In the pre
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c1427db9cab9f2ba313f03047e7afdac
https://pubmed.ncbi.nlm.nih.gov/23150279
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9
Increasing the general level of academic capacity in general practice: introducing mandatory research training for general practitioner trainees through a participatory research process
Autor: Charlotte, Tulinius, Anni Brit Sternhagen, Nielsen, Lars J, Hansen, Christian, Hermann, Lioudmila, Vlasova, Rikke, Dalsted
Publikováno v: Quality in primary care. 20(1)
To obtain good quality evidence-based clinical work there needs to be a culture of critical appraisal, and strong bridges between the clinical and the academic worlds in general practice.The aim was to educate the general practitioner (GP) trainees t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9684e708e020a0f89fea97d928c52433
https://pubmed.ncbi.nlm.nih.gov/22584368
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10
Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients
Autor: Trine Henriksen, Volkert Siersma, Steen Joop Bonnema, Allan Weimann, Jan Erik Henriksen, Henrik E. Poulsen, Lars J. Hansen, Jon Trærup Andersen, Espen Jimenez-Solem, Elisabeth S. Stovgaard, Kasper Broedbaek, Morten Petersen, Niels de Fine Olivarius
Publikováno v: Broedbaek, K, Siersma, V D, Henriksen, T M, Weimann, A, Petersen, M, Andersen, J T T, Jimenez-Solem, E, Stovgaard, E S, Hansen, L J, Henriksen, J E, Bonnema, S J, Olivarius, N D F & Poulsen, H E 2011, ' Urinary markers of nucleic acid oxidation and long-term mortality of newly diagnosed type 2 diabetic patients ', Diabetes Care. Supplement, vol. 34, no. 12, pp. 2594-6 . https://doi.org/10.2337/dc11-1620
Diabetes Care
OBJECTIVE We analyzed data from a cohort of 1,381 newly diagnosed type 2 diabetic patients to test the hypothesis that urinary markers of nucleic acid oxidation are independent predictors of mortality. RESEARCH DESIGN AND METHODS We examined the rela
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85a1074763cc17bf6a85863be4f9ea20
https://portal.findresearcher.sdu.dk/da/publications/45b7c114-a088-47b5-aa17-7752db21ed93
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