Výsledky vyhledávání - "Lars Ivar Elding"

Reduction of ormaplatin by an extended series of thiols unravels a remarkable correlation

Autor: Tiesheng Shi, Jingran Dong, Hongwu Tian, Lars Ivar Elding, Changying Song

Publikováno v: Dalton Transactions. 47:5548-5552

Ormaplatin ([Pt(dach)Cl4]) represents one of the three primary structural prototypes of Pt(iv) anticancer-active prodrugs. The reduction of ormaplatin by an extended series of thiols has been studied kinetically in a broad pH range. A novel and remar

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aec1c9431911607132037293bb99e62
https://doi.org/10.1039/c8dt00852c

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Investigations of the Kinetics and Mechanism of Reduction of a Carboplatin Pt(IV) Prodrug by the Major Small-Molecule Reductants in Human Plasma

Autor: Liyao Xu, Lars Ivar Elding, Jinhu Wang, Yang Liu, Tiesheng Shi, Benyan Xu, Li Zhou, Hongwu Tian, Chunli Liu

Publikováno v: International Journal of Molecular Sciences
Volume 20
Issue 22

The development of Pt(IV) anticancer prodrugs to overcome the detrimental side effects of Pt(II)-based anticancer drugs is of current interest. The kinetics and reaction mechanisms of the reductive activation of the carboplatin Pt(IV) prodrug cis,tra

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http://europepmc.org/articles/PMC6888404

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Kinetics and mechanism for reduction of Pt(IV) anticancer model compounds by Se-methyl L-selenocysteine. Comparison with L-selenomethionine

Autor: Hongwu Tian, Lars Ivar Elding, Haiping Yao, Tiesheng Shi, Chunli Liu, Liyao Xu

Publikováno v: Journal of Molecular Liquids; 2018(271), pp 838-843 (2018)

Se-methyl L-selenocysteine (MeSeCys) is one of the major organic selenium compounds acquired from the diet by human beings. It has been shown to have anticancer activity and cancer prevention functions. However, its antioxidant activity, largely rela

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https://lup.lub.lu.se/record/960f904a-7ac4-4bf1-8732-de73947c55fb

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Reactivity of the glutathione species towards the reduction of ormaplatin (or tetraplatin)

Autor: Shuying Huo, Tiesheng Shi, Jianzhong Xu, Jingran Dong, Shigang Shen, Lars Ivar Elding

Publikováno v: Bioorganicmedicinal chemistry letters. 26(17)

The reduction of ormaplatin (tetraplatin), a prototype for Pt(IV) anticancer prodrugs, by glutathione (GSH) was kinetically characterized over a wide pH range at 25.0 °C and 1.0 M ionic strength. The reduction follows overall second-order kinetics,

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https://pubmed.ncbi.nlm.nih.gov/27481559

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Kinetics and Equilibria for Complex Formation between Palladium(II) and Chloroacetate

Autor: Lars Ivar Elding, Premysl Lubal

Publikováno v: Journal of Solution Chemistry. 35:769-783

Kinetics and equilibria for the formation of a 1:1 complex between palladium(II) and chloroacetate were studied by spectrophotometric measurements in 1.00 mol . dm(-3) HClO4 at 298.2 K. The equilibrium constant, K, of the reaction Pd2+ + HL reversibl

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https://doi.org/10.1007/s10953-006-9019-z

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Synthesis of 14-oxa-1,4,8,11-tetraazabicyclo[9.5.3]nonadecane (L1) and a Spectroscopic and Structural Study of [Ni(L1)(ClO4)](ClO4) and of the Macrobicyclic Precursor Diamide Complex, [Ni(HL2)](ClO4); Chloride Substitution Kinetics of the Corresponding [Ni(III)(L1)]3+ Species

Autor: Lars Ivar Elding, Rodopoulos T, Rodopoulos M, McAuley A, J N Bridson, Steven J. Rettig

Publikováno v: Inorganic Chemistry. 40:2737-2742

The pentadentate ligand 14-oxa-1,4,8,11-tetraazabicyclo[9.5.3]nonadecane (L1) has been synthesized by the high dilution cyclization of 1-oxa-4,8-diazacyclododecane ([10]aneN2O) (1) with 1,3-bis(α-chloroacetamido)propane (2) and subsequent reduction

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https://doi.org/10.1021/ic001163r

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Kinetics and Mechanism for Reversible Chloride Transfer between Mercury(II) and Square-Planar Platinum(II) Chloro Ammine, Aqua, and Sulfoxide Complexes. Stabilities, Spectra, and Reactivities of Transient Metal−Metal Bonded Platinum−Mercury Adducts

Autor: Robert J. Deeth, Östen Gröning, Alan M. Sargeson, Lars Ivar Elding

Publikováno v: Inorganic Chemistry. 39:4286-4294

The Hg2+aq- and HgCl+aq-assisted aquations of [PtCl4]2- (1), [PtCl3(H2O)]- (2), cis-[PtCl2(H2O)2] (3), trans-[PtCl2(H2O)2] (4), [PtCl(H2O)3]+ (5), [PtCl3Me2SO]- (6), trans-[PtCl2(H2O)Me2SO] (7), cis-[PtCl(H2O)2Me2SO]+ (8), trans-[PtCl(H2O)2M32SO]+ (9

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https://doi.org/10.1021/ic000320j

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Kinetics and mechanism for reduction of anticancer-active tetrachloroam(m)ine platinum(IV) compounds by glutathione

Autor: Lars Ivar Elding, Nicholas Farrell, Kelemu Lemma, Johan Berglund

Publikováno v: JBIC Journal of Biological Inorganic Chemistry. 5:300-306

Glutathione (GSH) reduction of the anticancer-active platinum(IV) compounds trans-[PtCl4(NH3)(thiazole)] (1), trans-[PtCl4(cha)(NH3)] (2), cis-[PtCl4(cha)(NH3)] (3) (cha=cyclohexylamine), and cis-[PtCl4(NH3)2] (4) has been investigated at 25 degrees

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https://doi.org/10.1007/pl00010658

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Kinetics and Mechanism for Reduction of the Anticancer Prodrug trans,trans,trans-[PtCl2(OH)2(c-C6H11NH2)(NH3)] (JM335) by Thiols

Autor: Tiesheng Shi, Kelemu Lemma, Lars Ivar Elding

Publikováno v: Inorganic Chemistry. 39:1728-1734

The reduction of the platinum(IV) prodrug trans,trans,trans-[PtCl2(OH)2(c-C6H11NH2)(NH3)] (JM335) by L-cysteine, DL-penicillamine, DL-homocysteine, N-acetyl-L-cysteine, 2-mercaptopropanoic acid, 2-mercaptosuccinic acid, and glutathione has been inves

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https://doi.org/10.1021/ic991351l

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Kinetics and mechanism for reduction of oral anticancer platinum(IV) dicarboxylate compounds by L-ascorbate ions †

Autor: Alan M. Sargeson, Lars Ivar Elding, Kelemu Lemma

Publikováno v: Journal of the Chemical Society, Dalton Transactions. :1167-1172

Ascorbate (Asc) reductions of the oral anticancer platinum(IV) prodrugs cis,trans,cis-[PtCl2(OAc)2(cha)(NH3)] (JM216) and cis,trans,cis-[PtCl2(OCOC3H7)2(cha)(NH3)] (JM221) and of the isomers of JM216, viz.trans,cis,cis-[PtCl2(OAc)2(cha)(NH3)] (JM394)

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https://doi.org/10.1039/a909484i

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