Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Lars H. Nordenmark"'
Autor:
Frank Trudo, Lars H. Nordenmark, Rosa Lamarca, Gary T. Ferguson, Tor Skärby, Audrone Aksomaityte, Ileen Gilbert, Dan Lythgoe
Publikováno v:
International Journal of Chronic Obstructive Pulmonary Disease. 15:3123-3134
Purpose Moderate and severe COPD exacerbations are a significant health-care burden, but patients also experience “mild” exacerbations, or COPD symptom-related attacks, which often go unreported. We aimed to define and then determine the incidenc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c2594b73e57b0841a0c4847225933ce0
https://doi.org/10.2147/copd.s277147
https://doi.org/10.2147/copd.s277147
Late Breaking Abstract - Impact of COPD symptom-related attacks on quality of life and exacerbations
Autor:
Frank Trudo, Gary T. Ferguson, Ileen Gilbert, Audrone Aksomaityte, Rosa Lamarca, Tor Skärby, Dan Lythgoe, Lars H. Nordenmark
Publikováno v:
Airway pharmacology and treatment.
Introduction: Mild COPD exacerbations are defined as acute worsening of respiratory symptoms requiring only short-acting bronchodilator therapy. Previous post-hoc analysis of the RISE study showed that mild exacerbations, or COPD symptom-related atta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::66a8d04d9f554d50ec61caa666e509b6
https://doi.org/10.1183/13993003.congress-2019.oa258
https://doi.org/10.1183/13993003.congress-2019.oa258
Autor:
Ileen Gilbert, Rosa Lamarca, Frank Trudo, A. Aksomaityte, Lars H. Nordenmark, Tor Skärby, G.T. Ferguson, D. Lythgoe
Publikováno v:
D101. CLINICAL AND TRANSLATIONAL STUDIES IN ASTHMA AND COPD.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3a16278a65ab3c97dc1943fc447572d8
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7099
https://doi.org/10.1164/ajrccm-conference.2019.199.1_meetingabstracts.a7099
Autor:
Peter H. Howarth, Lars H. Nordenmark, Michel Laviolette, Himanshu Parikh, Vibeke Backer, Tina Skjold, Salman Siddiqui, Ingrid Louise Titlestad, Ronald Olivenstein, Dave Singh, Læge Carl Nielsen, Richard J. Russell, Gene L. Colice, Martin Braddock, Millie Wang, Latifa Chachi, Christopher E. Brightling, Lorcan McGarvey, Rekha Chaudhuri, Charlotte Suppli Ulrik, David Cohen, Brian Leaker, J. Mark FitzGerald, Tim Harrison
Publikováno v:
Russell, R J, Chachi, L, FitzGerald, J M, Backer, V, Olivenstein, R, Titlestad, I L, Ulrik, C S, Harrison, T, Singh, D, Chaudhuri, R, Leaker, B, McGarvey, L, Siddiqui, S, Wang, M, Braddock, M, Nordenmark, L H, Cohen, D, Parikh, H, Colice, G, Brightling, C E, Laviolette, M, Skjold, T, Nielsen, L C & Howarth, P 2018, ' Effect of tralokinumab, an interleukin-13 neutralising monoclonal antibody, on eosinophilic airway inflammation in uncontrolled moderate-to-severe asthma (MESOS) : a multicentre, double-blind, randomised, placebo-controlled phase 2 trial ', The Lancet Respiratory Medicine, vol. 6, no. 7, pp. 499-510 . https://doi.org/10.1016/S2213-2600(18)30201-7
Summary Background The role of interleukin 13 in airway inflammation and remodelling in asthma is unclear. Tralokinumab is a human monoclonal antibody that neutralises interleukin 13. We aimed to evaluate whether tralokinumab would have an effect on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0a60efc644236cce1b08a5d96e75de01
https://pubmed.ncbi.nlm.nih.gov/29793858
https://pubmed.ncbi.nlm.nih.gov/29793858
Autor:
Martin Braddock, Millie Wang, Christopher E. Brightling, Mattis Gottlow, Gene L. Colice, Lars H. Nordenmark
Publikováno v:
Clinical Investigation. 5:713-722
Eosinophils are key effector cells in asthma-associated airway inflammation and remodeling; IL-13 is involved in regulating eosinophil activity. Tralokinumab, currently in Phase III clinical development for patients with severe uncontrolled asthma, i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::123f1bbe8babe591fa4612695b449741
https://doi.org/10.4155/cli.15.36
https://doi.org/10.4155/cli.15.36
Autor:
Edward Piper, Gene L. Colice, Meena Jain, Göran Tornling, Martin Braddock, Dewei She, Lars H. Nordenmark, Christopher E. Brightling
Publikováno v:
American Journal of Respiratory and Critical Care Medicine. 194:118-120
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4555d84a16d0a29cab8455d88282d8fd
https://doi.org/10.1164/rccm.201511-2224le
https://doi.org/10.1164/rccm.201511-2224le
Autor:
Pechin Lo, Jesper Holst Pedersen, Asger Dirksen, Mathilde M. W. Wille, Mads Nielsen, Lars H. Nordenmark, Marleen de Bruijne, Jens Petersen
Publikováno v:
Medical Image Analysis, 18(3), 531-541. Elsevier
This paper introduces a graph construction method for multi-dimensional and multi-surface segmentation problems. Such problems can be solved by searching for the optimal separating surfaces given the space of graph columns defined by an initial coars
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0eee161404d3a7c5ae221da4570406e
https://doi.org/10.1016/j.media.2014.02.004
https://doi.org/10.1016/j.media.2014.02.004
Autor:
Martin Braddock, Gene L. Colice, Lars H. Nordenmark, Göran Tornling, Edward Piper, Meena Jain, Dewei She, Christopher E. Brightling
Publikováno v:
5.1 Airway Pharmacology and Treatment.
Introduction: The effects of the anti-IL-13 monoclonal antibody tralokinumab (tralo) (CAT-354) on airway dimensions were assessed in a subgroup of subjects from a Phase 2b study. Methods: In a 52-week double-blind study (NCT01402986) adults with seve
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44b26ba2ef38f15e0fe76032492cd1c3
https://doi.org/10.1183/13993003.congress-2015.pa2119
https://doi.org/10.1183/13993003.congress-2015.pa2119
Publikováno v:
Advances in therapy. 32(6)
The aim of this study was to establish the feasibility of using computed tomography (CT) in a multicenter setting to assess structural airway changes. This was a 12-week, randomized, double-blind, placebo-controlled, Phase IIb trial using CT to inves
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dcd330b8a112606fd76e98aa4f1a9a6b
https://pubmed.ncbi.nlm.nih.gov/26043724
https://pubmed.ncbi.nlm.nih.gov/26043724
Autor:
Josephine H. Naish, Yu-Zhen Liu, Geoffrey J. M. Parker, Lars H. Nordenmark, Dave Singh, Weijuan Zhang, Simon Young, Eva Bondesson, Penny L. Hubbard Cristinacce
Publikováno v:
Zhang, W-J, Hubbard Cristinacce, P, Bondesson, E, Nordenmark, L H, Young, S S, Liu, Y-Z, Singh, D, Naish, J H & Parker, G JM 2015, ' MR Quantitative Equilibrium Signal Mapping: A Reliable Alternative to CT in the Assessment of Emphysema in Patients with Chronic Obstructive Pulmonary Disease ', Radiology, vol. 275, no. 2, pp. 579-588 . https://doi.org/10.1148/radiol.14132953
PURPOSE: To compare magnetic resonance (MR) quantitative equilibrium signal (qS0) mapping with quantitative computed tomography (CT) in the estimation of emphysema in patients with chronic obstructive pulmonary disease (COPD). MATERIALS AND METHODS:
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18eb5e6ac921c05966a0794fa92bdc8a
https://pubmed.ncbi.nlm.nih.gov/25575114
https://pubmed.ncbi.nlm.nih.gov/25575114