Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis

Autor: John A. Lees, Bart Ferwerda, Philip H. C. Kremer, Nicole E. Wheeler, Mercedes Valls Serón, Nicholas J. Croucher, Rebecca A. Gladstone, Hester J. Bootsma, Nynke Y. Rots, Alienke J. Wijmega-Monsuur, Elisabeth A. M. Sanders, Krzysztof Trzciński, Anne L. Wyllie, Aeilko H. Zwinderman, Leonard H. van den Berg, Wouter van Rheenen, Jan H. Veldink, Zitta B. Harboe, Lene F. Lundbo, Lisette C. P. G. M. de Groot, Natasja M. van Schoor, Nathalie van der Velde, Lars H. Ängquist, Thorkild I. A. Sørensen, Ellen A. Nohr, Alexander J. Mentzer, Tara C. Mills, Julian C. Knight, Mignon du Plessis, Susan Nzenze, Jeffrey N. Weiser, Julian Parkhill, Shabir Madhi, Thomas Benfield, Anne von Gottberg, Arie van der Ende, Matthijs C. Brouwer, Jeffrey C. Barrett, Stephen D. Bentley, Diederik van de Beek

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)

Streptococcus pneumoniae is a causative agent of meningitis and bacteremia. In a combined pathogen and host GWAS, Lees et al. find that host genetic variation is associated with both susceptibility and severity of pneumococcal meningitis, and specifi

Externí odkaz: https://doaj.org/article/676c4fca20864aaa9d086a45a85f61c3

FTO genetic variants, dietary intake and body mass index: insights from 177 330 individuals

Autor: Frida Renström, Audrey Y. Chu, Ruth J. F. Loos, Torben Hansen, George Dedoussis, Toshiko Tanaka, W M Monique Verschuren, Denise K. Houston, Albert Hofman, Frank J. A. van Rooij, David J. Hunter, Yu Mi Kim, Ingrid B. Borecki, Majken K. Jensen, M. Carola Zillikens, Lars H. Ängquist, Marju Orho-Melander, David S. Siscovick, Stavroula Kanoni, Denise H. M. Heppe, Panos Deloukas, Dariush Mozaffarian, Nanette R. Lee, Paul M. Ridker, Tuomas O. Kilpeläinen, Nita G. Forouhi, Tarunveer S. Ahluwalia, Vera Mikkilä, Caren E. Smith, Kurt Lohman, Julius S. Ngwa, Yanping Li, Qibin Qi, Kay-Tee Khaw, Pedro Marques-Vidal, Claude Bouchard, Lu Qi, Jacqueline C.M. Witteman, Maarit A. Laaksonen, Muhammad Asif Ali, Robert Luben, Lene Christiansen, Johan G. Eriksson, Yechiel Friedlander, Peter Vollenweider, Shigeru Karasawa, Emily Sonestedt, Louis R. Pasquale, Peng Chen, Jirong Long, Cyrus Cooper, Harri Rissanen, Mi Kyung Kim, Ani Manichaikul, Kari E. North, Yu-Tang Gao, Wanqing Wen, Xu Lin, Terho Lehtimäki, Jaakko Tuomilehto, Matti Uusitupa, Oscar H. Franco, Yongmei Liu, Zhonghua Liu, Tao Wang, Nicholas J. Wareham, Ingegerd Johansson, Olli T. Raitakari, John W. Holloway, Oluf Pedersen, Mary K. Wojczynski, L. Adrienne Cupples, Daniel I. Chasman, Huaixing Li, Torben Jørgensen, Satu Männistö, Jingwen Zhu, Tuomo Rankinen, Wei Zheng, Karen L. Mohlke, Jae H. Kang, Frank B. Hu, Louis Pérusse, Gary C. Curhan, Tiina Jääskeläinen, Xiaochen Lin, Keri L. Monda, Kati Kristiansson, Rozenn N. Lemaitre, Ivonne Sluijs, Makoto Daimon, Xiao-Ou Shu, Yvonne T. van der Schouw, M. Perola, Min Xu, Paul W. Franks, Ulla Toft, E. Shyong Tai, Mary K. Downer, Jolanda M. A. Boer, Thorkild I. A. Sørensen, André G. Uitterlinden, Luigi Ferrucci, Jennifer A. Nettleton, Wei Lu, Liming Liang, Yong-Bing Xiang, Jinyan Huang, Qiuyin Cai

Publikováno v: Qi, Q, Kilpeläinen, T O, Downer, M K, Tanaka, T, Smith, C E, Sluijs, I, Sonestedt, E, Chu, A Y, Renström, F, Lin, X, Angquist, L H, Huang, J, Liu, Z, Li, Y, Asif Ali, M, Xu, M, Ahluwalia, T S, Boer, J M A, Chen, P, Daimon, M, Eriksson, J, Perola, M, Friedlander, Y, Gao, Y-T, Heppe, D H M, Holloway, J W, Houston, D K, Kanoni, S, Kim, Y-M, Laaksonen, M A, Jääskeläinen, T, Lee, N R, Lehtimäki, T, Lemaitre, R N, Lu, W, Luben, R N, Manichaikul, A, Männistö, S, Marques-Vidal, P, Monda, K L, Ngwa, J S, Perusse, L, van Rooij, F J A, Xiang, Y-B, Wen, W, Wojczynski, M K, Zhu, J, Borecki, I B, Bouchard, C, Cai, Q, Cooper, C, Dedoussis, G V, Deloukas, P, Ferrucci, L, Forouhi, N G, Hansen, T, Christiansen, L, Hofman, A, Johansson, I, Jørgensen, T, Karasawa, S, Khaw, K-T, Kim, M-K, Kristiansson, K, Li, H, Lin, X, Liu, Y, Lohman, K K, Long, J, Mikkilä, V, Mozaffarian, D, North, K, Pedersen, O, Raitakari, O, Rissanen, H, Tuomilehto, J, van der Schouw, Y T, Uitterlinden, A G, Carola Zillikens, M, Franco, O H, Shyong Tai, E, Ou Shu, X, Siscovick, D S, Toft, U, Monique Verschuren, W M, Vollenweider, P, Wareham, N J, Witteman, J C M, Zheng, W, Ridker, P M, Kang, J H, Liang, L, Jensen, M K, Curhan, G C, Pasquale, L R, Hunter, D J, Mohlke, K L, Uusitupa, M, Adrienne Cupples, L, Rankinen, T, Orho-Melander, M, Wang, T, Chasman, D I, Franks, P W, Sørensen, T I A, Hu, F B, Loos, R J F, Nettleton, J A & Qi, L 2014, ' FTO genetic variants, dietary intake and body mass index : insights from 177 330 individuals ', Human Molecular Genetics, vol. 23, no. 25, pp. 6961-6972 . https://doi.org/10.1093/hmg/ddu411
Human Molecular Genetics, 23(25), 6961-6972. Oxford University Press
Human Molecular Genetics, vol. 23, no. 25, pp. 6961-6972

FTO is the strongest known genetic susceptibility locus for obesity. Experimental studies in animals suggest the potential roles of FTO in regulating food intake. The interactive relation among FTO variants, dietary intake and body mass index (BMI) i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a373a7f5c340f4a01d15014e0ff098e0
http://doc.rero.ch/record/292154/files/ddu411.pdf