A high-resolution in vivo atlas of the human brain's benzodiazepine binding site of GABAA receptors

Autor: Martin Nørgaard, Vincent Beliveau, Melanie Ganz, Claus Svarer, Lars H Pinborg, Sune H Keller, Peter S Jensen, Douglas N. Greve, Gitte M. Knudsen

Publikováno v: NeuroImage, Vol 232, Iss , Pp 117878- (2021)

Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the human brain and plays a key role in several brain functions and neuropsychiatric disorders such as anxiety, epilepsy, and depression. For decades, several in vivo and ex vi

Externí odkaz: https://doaj.org/article/d03bbbc3812b4e9abc8fe5b6bdce7aa2

Ictal and interictal SPECT with 99mTc‐HMPAO in presurgical epilepsy. II: Methodological considerations on hyper‐ and hypoperfusion

Autor: Martin Prener, Veronica Drejer, Morten Ziebell, Per Jensen, Camilla Gøbel Madsen, Svitlana Olsen, Gerda Thomsen, Lars H. Pinborg, Olaf B. Paulson

Publikováno v: Epilepsia Open, Vol 8, Iss 4, Pp 1503-1511 (2023)

Abstract Objective Single‐photon emission computed tomography (SPECT) with the tracer 99mTc‐HMPAO is a method to visualize the cerebral hyperperfusion during an epileptic seizure and thus localize the epileptogenic zone and seizure propagation. S

Externí odkaz: https://doaj.org/article/20cadc0d72f34da6b6a7ae857779953a

Deep phenotyping towards precision psychiatry of first-episode depression — the Brain Drugs-Depression cohort

Autor: Kristian Høj Reveles Jensen, Vibeke H. Dam, Melanie Ganz, Patrick MacDonald Fisher, Cheng-Teng Ip, Anjali Sankar, Maja Rou Marstrand-Joergensen, Brice Ozenne, Merete Osler, Brenda W. J. H. Penninx, Lars H. Pinborg, Vibe Gedsø Frokjaer, Gitte Moos Knudsen, Martin Balslev Jørgensen

Publikováno v: BMC Psychiatry, Vol 23, Iss 1, Pp 1-15 (2023)

Abstract Background Major Depressive Disorder (MDD) is a heterogenous brain disorder, with potentially multiple psychosocial and biological disease mechanisms. This is also a plausible explanation for why patients do not respond equally well to treat

Externí odkaz: https://doaj.org/article/5c5e9049498647299c8ad0ed52ae3969

Striatal Volume Increase After Six Weeks of Selective Dopamine D2/3 Receptor Blockade in First-Episode, Antipsychotic-Naïve Schizophrenia Patients

Autor: Helle G. Andersen, Jayachandra M. Raghava, Claus Svarer, Sanne Wulff, Louise B. Johansen, Patrick K. Antonsen, Mette Ø. Nielsen, Egill Rostrup, Anthony C. Vernon, Lars T. Jensen, Lars H. Pinborg, Birte Y. Glenthøj, Bjørn H. Ebdrup

Publikováno v: Frontiers in Neuroscience, Vol 14 (2020)

Patients with chronic schizophrenia often display enlarged striatal volumes, and antipsychotic drugs may contribute via the dopamine D2/3 receptor (D2/3R) blockade. Separating the effects of disease from medication is challenging due to the lack of a

Externí odkaz: https://doaj.org/article/bf7facf14d5340eca56fdadecd72d8eb

Postprocessing of MRIs Using FreeSurfer in Epilepsy Surgery Patients Provides an Excellent Imaging Marker of Hippocampal Sclerosis but Fails to Separate Subtypes

Autor: Ane G. Kloster, Giske Opheim, Kristin Å. Alfstad, Karen B. Larsen, Pitt Niehusmann, Emil Holm, Philip Fink-Jensen, Eva Løbner Lund, Bo Jespersen, Jugoslav Ivanovic, Guido Rubboli, Camilla G. Madsen, Pål B. Marthinsen, Melanie Ganz, Morten Lossius, Lars H. Pinborg

Publikováno v: Kloster, A G, Opheim, G, Alfstad, K, Larsen, K B, Niehusmann, P, Holm, E, Fink-Jensen, P, Lund, E L, Jespersen, B, Ivanovic, J, Rubboli, G, Madsen, C G, Marthinsen, P B, Ganz, M, Lossius, M & Pinborg, L H 2023, ' Postprocessing of MRIs Using FreeSurfer in Epilepsy Surgery Patients Provides an Excellent Imaging Marker of Hippocampal Sclerosis but Fails to Separate Subtypes ', Acta Neurologica Scandinavica, vol. 2023, 2366355 . https://doi.org/10.1155/2023/2366355

Objective. Histopathological examinations will diminish as minimally invasive epilepsy surgery increasingly replaces open surgery. The objective of this study was to test if visual and computer-aided quantitative analyses of presurgical high-quality

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a0953e159ec6d4958473fa746ca488e
https://curis.ku.dk/portal/da/publications/postprocessing-of-mris-using-freesurfer-in-epilepsy-surgery-patients-provides-an-excellent-imaging-marker-of-hippocampal-sclerosis-but-fails-to-separate-subtypes(ad84ecd5-f7ff-42b1-927a-c89e3cf35c81).html