Zobrazeno 1 - 10
of 55
pro vyhledávání: '"Lars Grundemar"'
Autor:
James A. Russell, Jean-Louis Vincent, Anne Louise Kjølbye, Håkan Olsson, Allan Blemings, Herbert Spapen, Peder Carl, Pierre-Francois Laterre, Lars Grundemar
Publikováno v:
Critical Care, Vol 21, Iss 1, Pp 1-10 (2017)
Abstract Background Vasopressin is widely used for vasopressor support in septic shock patients, but experimental evidence suggests that selective V1A agonists are superior. The initial pharmacodynamic effects, pharmacokinetics, and safety of selepre
Externí odkaz:
https://doaj.org/article/505f99780d0745ac933aa3723f311773
Publikováno v:
Basic & Clinical Pharmacology & Toxicology. 123:589-593
Paracetamol overdosing may cause liver injury including fulminant liver failure due to generation of the toxic metabolites, N-acetyl-p-benzoquinone imine (NAPQI) and p-benzoquinone (p-BQ). Herein, the chelating agent, N,N'-Bis(2-mercaptoethyl)isophth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c95d59791de90ceac4fc4eeda62169f2
https://doi.org/10.1111/bcpt.13058
https://doi.org/10.1111/bcpt.13058
Publikováno v:
Clinical Drug Investigation
Background and Objectives Degarelix is a gonadotropin-releasing hormone antagonist registered for the treatment of advanced hormone-dependent prostate cancer. Treatment causing androgen deprivation is associated with QT prolongation and this study in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d85ca545714695911684a0ab882d26e
https://doi.org/10.1007/s40261-017-0547-7
https://doi.org/10.1007/s40261-017-0547-7
Autor:
Lars Grundemar, Christophe Mallet, Ludivine Boudieu, Anders Blomgren, Johan L. Å. Nilsson, Anders Blomqvist, Peter M. Zygmunt, Ulf J. Nilsson, Kiseko Shionoya, Anders Sundin, Alain Eschalier
Publikováno v:
European Journal of Medicinal Chemistry. 213:113042
Paracetamol, one of the most widely used pain-relieving drugs, is deacetylated to 4-aminophenol (4-AP) that undergoes fatty acid amide hydrolase (FAAH)-dependent biotransformation into N-arachidonoylphenolamine (AM404), which mediates TRPV1-dependent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0916dc1b1112f9814a25b88a17da4dd
https://doi.org/10.1016/j.ejmech.2020.113042
https://doi.org/10.1016/j.ejmech.2020.113042
Publikováno v:
Drugs in R&D
Objective The aim of this study was to characterise the population pharmacokinetics of FE 999049, a novel recombinant human follicle-stimulating hormone (FSH), after multiple dosing in healthy women, taking into account endogenous FSH levels and the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b91eb35d3ccd56f91fa75d0290f78b7
https://doi.org/10.1007/s40268-016-0126-z
https://doi.org/10.1007/s40268-016-0126-z
Autor:
Lars Grundemar, Peder Carl, Pierre-François Laterre, Håkan Olsson, James A. Russell, Anne Louise Kjølbye, Jean Louis Vincent, Herbert D. Spapen, Allan Blemings
Publikováno v:
Critical Care
Critical care, 21 (1
Critical Care, Vol 21, Iss 1, Pp 1-10 (2017)
Critical care, 21 (1
Critical Care, Vol 21, Iss 1, Pp 1-10 (2017)
Background: Vasopressin is widely used for vasopressor support in septic shock patients, but experimental evidence suggests that selective V1A agonists are superior. The initial pharmacodynamic effects, pharmacokinetics, and safety of selepressin, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb12a2ee72464f7b3355992da8f6ebc5
https://biblio.vub.ac.be/vubir/selepressin-a-novel-selective-vasopressin-v1a-agonist-is-an-effective-substitute-for-norepinephrine-in-a-phase-iia-randomized-placebocontrolled-trial-in-septic-shock-patients(0e87a136-b01d-4588-b1d5-c94444969fa9).html
https://biblio.vub.ac.be/vubir/selepressin-a-novel-selective-vasopressin-v1a-agonist-is-an-effective-substitute-for-norepinephrine-in-a-phase-iia-randomized-placebocontrolled-trial-in-septic-shock-patients(0e87a136-b01d-4588-b1d5-c94444969fa9).html
Publikováno v:
The Journal of Clinical Pharmacology. 54:1299-1307
Pharmacokinetic and pharmacodynamic properties of a novel recombinant follicle-stimulating hormone (rFSH) preparation (FE 999049), expressed by a human cell line (PER.C6), was compared with an rFSH preparation (follitropin α) expressed by a Chinese
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d3692cf4ecd2c7fb1660edadf3150b3
https://doi.org/10.1002/jcph.328
https://doi.org/10.1002/jcph.328
Publikováno v:
Clinical Pharmacology in Drug Development. 3:358-364
This randomized, open-label, multiple-dose three-way cross-over study compared the pharmacokinetics of a new testosterone gel formulation in two strengths, testosterone gel 1% and testosterone gel 2% (FE 999303), with Testogel® in 11 testosterone-su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b7819d80405423f0a24b5ee7b6de93e6
https://doi.org/10.1002/cpdd.110
https://doi.org/10.1002/cpdd.110
Autor:
Lars Grundemar, Allan Blemings, Håkan Olsson, James A. Russell, Anne Louise Kjølbye, Jean Louis Vincent
Publikováno v:
Critical Care Medicine. 40:1-328
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2fd12f9e0069515f733af6703b4028dd
https://doi.org/10.1097/01.ccm.0000424318.70108.b2
https://doi.org/10.1097/01.ccm.0000424318.70108.b2
Publikováno v:
Proceedings for Annual Meeting of The Japanese Pharmacological Society. :PO3-2
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3d84302fa96bc6c3967b85648150278e
https://doi.org/10.1254/jpssuppl.wcp2018.0_po3-2-37
https://doi.org/10.1254/jpssuppl.wcp2018.0_po3-2-37