Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Lars Emil Larsen"'
Autor:
Lars Emil Larsen, Sielke Caestecker, Latoya Stevens, Pieter van Mierlo, Evelien Carrette, Paul Boon, Kristl Vonck, Robrecht Raedt
Publikováno v:
Neurobiology of Disease, Vol 189, Iss , Pp 106355- (2023)
The locus coeruleus (LC) is a small brainstem nucleus and is the sole source of noradrenaline in the neocortex, hippocampus and cerebellum. Noradrenaline is a powerful neuromodulator involved in the regulation of excitability and plasticity of large-
Externí odkaz:
https://doaj.org/article/603082e3265543fbb355c82ffccbd7ad
Autor:
Marijke Vergaelen, Simona Manzella, Kristl Vonck, Erine Craey, Jeroen Spanoghe, Mathieu Sprengers, Evelien Carrette, Wytse Jan Wadman, Jean Delbeke, Paul Boon, Lars Emil Larsen, Robrecht Raedt
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 1, p 660 (2024)
The intrahippocampal kainic acid (IHKA) mouse model is an extensively used in vivo model to investigate the pathophysiology of mesial temporal lobe epilepsy (mTLE) and to develop novel therapies for drug-resistant epilepsy. It is characterized by pro
Externí odkaz:
https://doaj.org/article/02afdd2faea84223b1ec2bc09f9cb2c9
Autor:
Wouter Van Lysebettens, Kristl Vonck, Lars Emil Larsen, Latoya Stevens, Charlotte Bouckaert, Charlotte Germonpré, Mathieu Sprengers, Evelien Carrette, Jean Delbeke, Wytse Jan Wadman, Paul Boon, Robrecht Raedt
Publikováno v:
Brain Stimulation, Vol 13, Iss 5, Pp 1198-1206 (2020)
Background: Recent experiments in rats have demonstrated significant effects of VNS on hippocampal excitability but were partially attributed to hypothermia, induced by the applied VNS parameters. Objective: To allow meaningful preclinical research o
Externí odkaz:
https://doaj.org/article/bb54b0e5c88b47a68751623caafbc8f1
Autor:
Latoya Stevens, Lars Emil Larsen, Wouter Van Lysebettens, Evelien Carrette, Paul Boon, Robrecht Raedt, Kristl Vonck
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
IntroductionThe locus coeruleus noradrenergic (LC-NA) system is studied for its role in various neurological and psychiatric disorders such as epilepsy and Major Depression Dissorder. Chemogenetics is a powerful technique for specific manipulation of
Externí odkaz:
https://doaj.org/article/c19bb790c0064be6a2ac19051fe17883
Autor:
Anirudh R. Acharya, Lars Emil Larsen, Wouter Van Lysebettens, Wytse Jan Wadman, Jean Delbeke, Kristl Vonck, Alfred Meurs, Paul Boon, Robrecht Raedt
Publikováno v:
Frontiers in Neuroscience, Vol 15 (2021)
AimGtACR2, a light-activated chloride channel, is an attractive tool for neural inhibition as it can shunt membrane depolarizations. In this study, we assessed the effect of activating GtACR2 on in vivo hippocampal CA1 activity evoked by Schaffer col
Externí odkaz:
https://doaj.org/article/b434432393974a9690de098d22b58a53
Autor:
Latoya Stevens, Kristl Vonck, Lars Emil Larsen, Wouter Van Lysebettens, Charlotte Germonpré, Veerle Baekelandt, Chris Van den Haute, Evelien Carrette, Wytse Jan Wadman, Paul Boon, Robrecht Raedt
Publikováno v:
Frontiers in Neuroscience, Vol 14 (2020)
AimSelective chemogenetic modulation of locus coeruleus (LC) neurons would allow dedicated investigation of the role of the LC-NA pathway in brain excitability and disorders such as epilepsy. This study investigated the feasibility of an experimental
Externí odkaz:
https://doaj.org/article/af0cdf13e6ad463cba8d3cb289629c3e
Autor:
Anirudh R. Acharya, Lars Emil Larsen, Jean Delbeke, Wytse J. Wadman, Kristl Vonck, Alfred Meurs, Paul Boon, Robrecht Raedt
Publikováno v:
CNS NEUROSCIENCE & THERAPEUTICS
AimsThe blue light-sensitive chloride-conducting opsin, stGtACR2, provides potent optogenetic silencing of neurons. The present study investigated whether activation of stGtACR2 in granule cells of the dentate gyrus (DG) inhibits epileptic afterdisch
Autor:
Lars Emil Larsen, Sielke Caestecker, Latoya Stevens, Pieter van Mierlo, Evelien Carrette, Paul Boon, Kristl Vonck, Robrecht Raedt
The locus coeruleus (LC), a brainstem nucleus, is the sole source of noradrenaline in the neocortex, hippocampus and cerebellum. Noradrenaline is a powerful neuromodulator involved in the regulation of excitability and plasticity of large-scale brain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c6f088018f656e5225e2f3d7823061f0
https://doi.org/10.1101/2023.03.06.531292
https://doi.org/10.1101/2023.03.06.531292
Autor:
Charlotte Bouckaert, Robrecht Raedt, Lars Emil Larsen, Riëm El Tahry, Stefanie Gadeyne, Evelien Carrette, Silke Proesmans, Frank Dewaele, Jean Delbeke, Veerle De Herdt, Alfred Meurs, Ann Mertens, Paul Boon, Kristl Vonck
Publikováno v:
Neuromodulation, p. 1-10 (2022)
Vagus nerve stimulation (VNS) is an adjunctive therapy for drug-resistant epilepsy. Noninvasive evoked potential recordings in laryngeal muscles (LMEPs) innervated by vagal branches may provide a marker to assess effective vagal nerve fiber activatio
Autor:
Robrecht Raedt, Kristl Vonck, Wytse Wadman, Marie-Gabrielle Goossens, Lars Emil Larsen, Paul Boon, Jean Delbeke, Jana Desloovere, Evelien Carrette
Publikováno v:
Neurotherapeutics
Expression of inhibitory designer receptors exclusively activated by designer drugs (DREADDs) on excitatory hippocampal neurons in the hippocampus represents a potential new therapeutic strategy for drug-resistant epilepsy. To overcome the limitation