Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Lars E T, Jansen"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Centromeres are unique chromosomal loci that form the anchorage point for the mitotic spindle during mitosis and meiosis. Their position and function are specified by a unique chromatin domain featuring the histone H3 variant CENP-A. While typically
Externí odkaz:
https://doaj.org/article/f44416f1193644b3af2cf70da8f935e4
Autor:
Georg O. M. Bobkov, Anming Huang, Sebastiaan J. W. van den Berg, Sreyoshi Mitra, Eduard Anselm, Vasiliki Lazou, Sarah Schunter, Regina Feederle, Axel Imhof, Alexandra Lusser, Lars E. T. Jansen, Patrick Heun
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
CENP-A is a stable centromere mark, although active transcription poses a potential threat for retaining CENP-A through chromatin remodeling and nucleosome eviction. Here, the authors show that maintenance of the centromeric mark is preserved by Spt6
Externí odkaz:
https://doaj.org/article/a5a494ec43084ed0a2ef6c3602611b58
Autor:
Sreyoshi Mitra, Dani L. Bodor, Ana F. David, Izma Abdul-Zani, João F. Mata, Beate Neumann, Sabine Reither, Christian Tischer, Lars E. T. Jansen
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-15 (2020)
Centromeres are a self-propagating chromatin structure that feature nucleosomes containing histone H3 variant CENP-A. Here, the authors screen for factors that play a role in CENP-A chromatin maintenance, finding that SUMO-protease SENP6 controls inh
Externí odkaz:
https://doaj.org/article/641a9f1477b540ab8b0adfe5757d8257
Publikováno v:
Open Biology, Vol 10, Iss 10 (2020)
Pluripotent stem cells (PSCs) are central to development as they are the precursors of all cell types in the embryo. Therefore, maintaining a stable karyotype is essential, both for their physiological role as well as for their use in regenerative me
Externí odkaz:
https://doaj.org/article/14c0084c80c34bbe88ae476a5c14d701
Publikováno v:
Molecular Biology of the Cell. 34
We show that centromeric chromatin size is maintained by a dynamic SUMO cycle driving centromeric protein turnover by the p97 segregase, which is opposed by the deSUMOylase SENP6, ensuring proper centromere and kinetochore function.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::11ee86f9f37c92811024a0020fbe2c67
https://doi.org/10.1091/mbc.e23-01-0035
https://doi.org/10.1091/mbc.e23-01-0035
Publikováno v:
PLoS ONE, Vol 7, Iss 2, p e32646 (2012)
Gene targeting protocols for mammalian cells remain inefficient and labor intensive. Here we describe FASTarget, a rapid, fluorescent cell sorting based strategy to isolate rare gene targeting events in human somatic cells. A fluorescent protein is u
Externí odkaz:
https://doaj.org/article/e011229d1c35449bad834876954edec2
Autor:
Alexander Samoshkin, Alexei Arnaoutov, Lars E T Jansen, Ilia Ouspenski, Louis Dye, Tatiana Karpova, James McNally, Mary Dasso, Don W Cleveland, Alexander Strunnikov
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6831 (2009)
Condensins I and II in vertebrates are essential ATP-dependent complexes necessary for chromosome condensation in mitosis. Condensins depletion is known to perturb structure and function of centromeres, however the mechanism of this functional link r
Externí odkaz:
https://doaj.org/article/66fdcfa1740f4cf090bee580246d0dc0
Publikováno v:
Methods in molecular biology (Clifton, N.J.). 1832
Understanding chromatin dynamics is essential to define the contribution of chromatin to heritable gene silencing and the long-term maintenance of gene expression. Here we present a detailed protocol for time-ChIP, a novel method to measure histone t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a6a13c562f1c86087b4d232733ed8990
https://pubmed.ncbi.nlm.nih.gov/30073525
https://pubmed.ncbi.nlm.nih.gov/30073525
Autor:
Ana, Stankovic, Lars E T, Jansen
Publikováno v:
Progress in molecular and subcellular biology. 56
Centromeres are chromatin domains specified by nucleosomes containing the histone H3 variant, CENP-A. This unique centromeric structure is at the heart of a strong self-templating epigenetic mechanism that renders centromeres heritable. We review how
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cb7b95e175b6d831ad9cd201a62c6d09
https://pubmed.ncbi.nlm.nih.gov/28840236
https://pubmed.ncbi.nlm.nih.gov/28840236
Autor:
Samantha J, Falk, Lucie Y, Guo, Nikolina, Sekulic, Evan M, Smoak, Tomoyasu, Mani, Glennis A, Logsdon, Kushol, Gupta, Lars E T, Jansen, Gregory D, Van Duyne, Sergei A, Vinogradov, Michael A, Lampson, Ben E, Black
Publikováno v:
Science (New York, N.Y.). 348(6235)
Inheritance of each chromosome depends upon its centromere. A histone H3 variant, centromere protein A (CENP-A), is essential for epigenetically marking centromere location. We find that CENP-A is quantitatively retained at the centromere upon which
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::de3713c5a473a2d03943c257a9bf734b
https://pubmed.ncbi.nlm.nih.gov/25954010
https://pubmed.ncbi.nlm.nih.gov/25954010