Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lars Dittus"'
Publikováno v:
Journal of Pharmaceutical Sciences.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1edd427e92772da67000857b6105ebd9
https://doi.org/10.1016/j.xphs.2023.04.008
https://doi.org/10.1016/j.xphs.2023.04.008
Autor:
Carsten Hopf, Anne J. Wagner, Daniel Poeckel, Christina Rau, Ray Edward Benson, Jana Krause, Gerard Drewes, John T. Moore, Elsa Salzer, John G. Emery, Douglas W. Thomson, Marcel Muelbaier, Lars Dittus, Katrin M. Mueller, Marcus Bantscheff, Birgit Duempelfeld, Lisa M. Shewchuk
Publikováno v:
Journal of Medicinal Chemistry. 60:5455-5471
The availability of high quality probes for specific protein targets is fundamental to the investigation of their function and their validation as therapeutic targets. We report the utilization of a dedicated chemoproteomic assay platform combining a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62a3dc6effb7282a8479009e93307f26
https://doi.org/10.1021/acs.jmedchem.7b00137
https://doi.org/10.1021/acs.jmedchem.7b00137
Autor:
John D. Harling, Hannah Lithgow, William J. Kerr, Marcus Bantscheff, Zuni I. Bassi, Marcel Muelbaier, Han Dai, Ian Edward David Smith, Christopher P. Tinworth, Sophie E. Hughes, Lars Dittus, Glenn A. Burley
The impact of covalent binding on PROTAC-mediated degradation of BTK was investigated through the preparation of both covalent binding and reversible binding PROTACs derived from the covalent BTK inhibitor ibrutinib. It was determined that a covalent
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::16bdbf2c7c16f7218b63c1d96ac63bb6
https://strathprints.strath.ac.uk/67192/1/Tinworth_etal_ACS_CB_2019_PROTAC_mediated_degradation_of_Brutons_tyrosine_kinase.pdf
https://strathprints.strath.ac.uk/67192/1/Tinworth_etal_ACS_CB_2019_PROTAC_mediated_degradation_of_Brutons_tyrosine_kinase.pdf
Autor:
John A. Murphy, Máire A. Convery, John P. Evans, Samuel E. Dalton, Marcus Bantscheff, Jacob T. Bush, João Osvaldo Rodrigues Nunes, Lars Dittus, Sebastien Andre Campos, Thilo Werner, Daniel Thomas
Publikováno v:
Journal of the American Chemical Society. 140(3)
Selective covalent inhibition of kinases by targeting poorly conserved cysteines has proven highly fruitful to date in the development of chemical probes and approved drugs. However, this approach is limited to ∼200 kinases possessing such a cystei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0354bde6215768f6ece32debb2c3125
https://pubmed.ncbi.nlm.nih.gov/29232121
https://pubmed.ncbi.nlm.nih.gov/29232121
Publikováno v:
ACS chemical biology. 12(10)
Chemoproteomics profiling of kinase inhibitors with kinobeads enables the assessment of inhibitor potency and selectivity for endogenously expressed protein kinases in cell lines and tissues. Using a small panel of targeted covalent inhibitors, we de
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fb3fe43c1c934a226b95e10f0cd507e
https://pubmed.ncbi.nlm.nih.gov/28876896
https://pubmed.ncbi.nlm.nih.gov/28876896
Autor:
Thilo Werner, Katrin M. Mueller, Marcus Bantscheff, Douglas W. Thomson, Jana Krause, Marcel Muelbaier, Johanna Vappiani, Giovanna Bergamini, Lars Dittus, Anna Rutkowska
Publikováno v:
ACS chemical biology. 11(9)
Late stage failures of candidate drug molecules are frequently caused by off-target effects or inefficient target engagement in vivo. In order to address these fundamental challenges in drug discovery, we developed a modular probe strategy based on b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec51e4ae4e6b387f54a2e630f696f57a
https://pubmed.ncbi.nlm.nih.gov/27384741
https://pubmed.ncbi.nlm.nih.gov/27384741