Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Lars Brunken"'
Autor:
Talveen S Purba, Kayumba Ng'andu, Lars Brunken, Eleanor Smart, Ellen Mitchell, Nashat Hassan, Aaron O'Brien, Charlotte Mellor, Jennifer Jackson, Asim Shahmalak, Ralf Paus
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
Abstract Taxanes are a leading cause of severe and often permanent chemotherapy‐induced alopecia. As the underlying pathobiology of taxane chemotherapy‐induced alopecia remains poorly understood, we investigated how paclitaxel and docetaxel damag
Externí odkaz:
https://doaj.org/article/90d9a44b6fc04a7aba33604064c0b735
Autor:
Violetta Nikiforova, Ian A. Cotgreave, Joëlle Rüegg, Arrabi Easwaranathan, Vesna Munic Kos, Lars Brunken, Patrik Kagebeck
Publikováno v:
European Journal of Pharmacology. 829:44-53
Some cationic amphiphilic drugs (CADs) have been individually reported to interfere with the differentiation of immune system cells, such as macrophages and dendritic cells. To investigate the possible generic nature of this process, in this study we
Autor:
Jennifer Jackson, Asim Shahmalak, Ellen Mitchell, Kayumba Ng'andu, Aaron O'Brien, Charlotte E L Mellor, Ralf Paus, Talveen S. Purba, Lars Brunken, Eleanor Smart, Nashat Hassan
Publikováno v:
EMBO Molecular Medicine, Vol 11, Iss 10, Pp n/a-n/a (2019)
EMBO Molecular Medicine
Purba, T, Ng'andu, K, Brunken, L, Lech, E, Mitchell, E, Hassan, N, O'Brien, A, Mellor, C, Jackson, J, Shahmalak, A & Paus, R 2019, ' CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia ', EMBO Molecular Medicine . https://doi.org/10.15252/emmm.201911031
EMBO Molecular Medicine
Purba, T, Ng'andu, K, Brunken, L, Lech, E, Mitchell, E, Hassan, N, O'Brien, A, Mellor, C, Jackson, J, Shahmalak, A & Paus, R 2019, ' CDK4/6 inhibition mitigates stem cell damage in a novel model for taxane-induced alopecia ', EMBO Molecular Medicine . https://doi.org/10.15252/emmm.201911031
Taxanes are a leading cause of severe and often permanent chemotherapy‐induced alopecia. As the underlying pathobiology of taxane chemotherapy‐induced alopecia remains poorly understood, we investigated how paclitaxel and docetaxel damage human s
Autor:
Violetta Nikiforova, Lars Brunken, Ulf Norinder, Arrabi Easwaranathan, Vesna Munic Kos, Beril Inci, Stephen Swanson, Sam Ulrich
Publikováno v:
Journal of pharmaceutical sciences. 108(1)
Many marketed pharmaceuticals reach extremely high tissue concentrations due to accumulation in lysosomes (lysosomotropism). Quantitative prediction of intracellular concentrations of accumulating drugs is challenging, especially for macrocyclic comp
Autor:
Ralf Paus, Michael Peake, Asuncion Chaves, Talveen S. Purba, Alberto Gandarillas, Asim Shahmalak, Enrique Poblet, Laura Sanz Ceballos, Lars Brunken
Publikováno v:
Purba, T, Brunken, L, Peake, M, Shahmalak, A, Chaves, A, Poblet, E, Ceballos, L, Gandarillas, A & Paus, R 2017, ' Characterisation of cell cycle arrest and terminal differentiation in a maximally proliferative human epithelial tissue: Lessons from the human hair follicle matrix ', European journal of cell biology . https://doi.org/10.1016/j.ejcb.2017.03.011
Human hair follicle (HF) growth and hair shaft formation require terminal differentiation-associated cell cycle arrest of highly proliferative matrix keratinocytes. However, the regulation of this complex event remains unknown. CIP/KIP family member
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7d7c8a9ad8df9fc2e8ac55313ffd8c6e
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/46375
https://publishup.uni-potsdam.de/frontdoor/index/index/docId/46375
Autor:
Michael Peake, Lars Brunken, Ralf Paus, Talveen S. Purba, Nathan J. Hawkshaw, Jonathan A. Hardman
Publikováno v:
Purba, T, Brunken, L, Hawkshaw, N, Hardman, J & Paus, R 2016, ' A Primer for Studying Cell Cycle Dynamics of the Human Hair Follicle ', Experimental Dermatology (Online), vol. 25, no. 9, pp. 663–668 . https://doi.org/10.1111/exd.13046
The cell cycle is of major importance to human hair follicle (HF) biology. Not only is continuously active cell cycling required to facilitate healthy hair growth in anagen VI HFs, but perturbations in the cell cycle are likely to be of significance