Zobrazeno 1 - 7
of 7
pro vyhledávání: '"Lars Brautigam"'
Publikováno v:
Biomolecules, Vol 7, Iss 3, p 49 (2017)
Accumulation of somatic mutations is critical for the transition of a normal cell to become cancerous. Mutations cause amino acid substitutions that change properties of proteins. However, it has not been studied as to what extent the composition and
Externí odkaz:
https://doaj.org/article/0cae49125ef24d55a546c8e9b5dc8efe
Autor:
Xuexin Li, Ivo Hernandez, Maria Häggblad, Louise Lidemalm, Lars Brautigam, Jose J. Lucas, Jordi Carreras-Puigvert, Daniela Hühn, Oscar Fernandez-Capetillo
SUMMARYPolyQ diseases are autosomal dominant neurodegenerative disorders caused by the expansion of CAG repeats. While of slow progression, these diseases are ultimately fatal and lack effective therapies. Here, we present our results from a High-Thr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fb2ccdf3e09145aff9bed89b6d515b86
https://doi.org/10.1101/2023.02.06.527298
https://doi.org/10.1101/2023.02.06.527298
Autor:
Ulrika Warpman Berglund, Helge Gad, Kumar Sanjiv, Ann-Sofie Jemth, Oliver Mortusewics, Lars Brautigam, Juha Rantala, Thomas Helleday
Publikováno v:
Cancer Research. 83:1569-1569
Many cancers suffer from replication stress, oxidative stress, a dysfunctional redox status, and high levels of endogenous oxidative DNA damage. OXC-101 (karonudib, TH1579) targets these vulnerabilities by stopping the cancer cells in mitosis, genera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ed71dcced4f57d61972a21acfffe6af2
https://doi.org/10.1158/1538-7445.am2023-1569
https://doi.org/10.1158/1538-7445.am2023-1569
Autor:
Christina Wilms, Klaudia Lepka, Felix Häberlein, Steven Edwards, Jörg Felsberg, Linda Pudelko, Tobias T. Lindenberg, Gereon Poschmann, Nan Qin, Katrin Volbracht, Tim Prozorovski, Sven G. Meuth, Ulf D. Kahlert, Marc Remke, Orhan Aktas, Guido Reifenberger, Lars Bräutigam, Benjamin Odermatt, Carsten Berndt
Publikováno v:
Redox Biology, Vol 49, Iss , Pp 102221- (2022)
Redox regulation of specific cysteines via oxidoreductases of the thioredoxin family is increasingly being recognized as an important signaling pathway. Here, we demonstrate that the cytosolic isoform of the vertebrate-specific oxidoreductase Glutare
Externí odkaz:
https://doaj.org/article/2e1d65566877484caf8912ee69a75699
Autor:
Lars Bräutigam, Jie Zhang, Kristian Dreij, Linda Spahiu, Arne Holmgren, Hiroshi Abe, Kenneth D. Tew, Danyelle M. Townsend, Michael J. Kelner, Ralf Morgenstern, Katarina Johansson
Publikováno v:
Redox Biology, Vol 17, Iss , Pp 171-179 (2018)
We show for the first time that, in contrast to other glutathione transferases and peroxidases, deletion of microsomal glutathione transferase 1 (MGST1) in mice is embryonic lethal. To elucidate why, we used zebrafish development as a model system an
Externí odkaz:
https://doaj.org/article/6112082f1b8143d8bfa088eb5a31f32c
Publikováno v:
Redox Biology, Vol 2, Iss C, Pp 673-678 (2014)
Glutaredoxin 2 is a vertebrate specific oxidoreductase of the thioredoxin family of proteins modulating the intracellular thiol pool. Thereby, glutaredoxin 2 is important for specific redox signaling and regulates embryonic development of brain and v
Externí odkaz:
https://doaj.org/article/c4b85886c6c64e95bede9e25e88eb8c2
Autor:
Lasse Dahl Jensen, Ziquan Cao, Masaki Nakamura, Yunlong Yang, Lars Bräutigam, Patrik Andersson, Yin Zhang, Eric Wahlberg, Toste Länne, Kayoko Hosaka, Yihai Cao
Publikováno v:
Cell Reports, Vol 2, Iss 2, Pp 231-241 (2012)
Molecular mechanisms underlying circadian-regulated physiological processes remain largely unknown. Here, we show that disruption of the circadian clock by both constant exposure to light and genetic manipulation of key genes in zebrafish led to impa
Externí odkaz:
https://doaj.org/article/1df50a98df884677873a7beaea138b6d