Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Lars Boukharta"'
Publikováno v:
PLoS Computational Biology, Vol 10, Iss 4, p e1003585 (2014)
Site-directed mutagenesis combined with binding affinity measurements is widely used to probe the nature of ligand interactions with GPCRs. Such experiments, as well as structure-activity relationships for series of ligands, are usually interpreted w
Externí odkaz:
https://doaj.org/article/ad9c8b7c7b9a4a5eb841bf423e044df6
Autor:
Lionel Trésaugues, Kilian Huber, Ioanna Panagakou, Camilla Silvander, F. Rahm, Martin Andersson, Antoine Talagas, Oleg Fedorov, Marcus Bauser, Tobias Ginman, L. Diaz-Saez, Ellermann Manuel, Kenth Hallberg, Rickard Forsblom, Johan Lindström, Mátyás Gorjánácz, Anja Giese, Judith Günther, Lars Boukharta Persson, P. Siejka, Jenny Viklund, Ulrika Ericsson
Publikováno v:
Journal of Medicinal Chemistry. 61(6)
Recent literature has both suggested and questioned MTH1 as a novel cancer target. BAY-707 was just published as a target validation small molecule probe for assessing the effects of pharmacological inhibition of MTH1 on tumor cell survival, both in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df850d12469fccbc99cfeb9d1e544696
http://ora.ox.ac.uk/objects/uuid:
http://ora.ox.ac.uk/objects/uuid:
Publikováno v:
Journal of Chemical Information and Modeling. 54:1488-1499
Cyclooxygenase-1 (COX-1) is one of the main targets of most pain-relieving pharmaceuticals. Although the enzyme is well characterized, it is known to be a difficult target for automated molecular docking and scoring. We collected from the literature
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b61b856b70e17ce15e62a6c7bf8044
https://doi.org/10.1021/ci500151f
https://doi.org/10.1021/ci500151f
Akademický článek
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Autor:
Anna Stary-Weinzinger, Bert L. de Groot, Göran Wallin, Johan Åqvist, Lars Boukharta, Henrik Keränen
Publikováno v:
Biochemistry
The hERG potassium channel is of major pharmaceutical importance, and its blockade by various compounds, potentially causing serious cardiac side effects, is a major problem in drug development. Despite the large amounts of existing biochemical data
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::993d23ffab077eb8319b68f21bad93e2
https://doi.org/10.1021/bi200173n
https://doi.org/10.1021/bi200173n
Autor:
Lewis C. Cantley, Albert S. Yu, Kannan Karukarichi, Fredrik Karlsson, Ellen Santangelo, Rui Wang, F. Rahm, Ulrika Ericsson, Johan Linstrom, Mariell Pettersson, Jessica Martinsson, Tiago Braga, Madeleine Livendahl, Aine Brigette Henley, Horst Wähling, Lars Boukharta Persson, Martin Andersson, Tobias Ginman, Andreas Hoglund, Parisa Zolfaghari, Rickard Forsblom, Jenny Viklund, Lionel Trésaugues, David L. McElligott, Hyeseok Shim, Antoine Talagas, Tommy Johansson, Kesicki Edward A
Publikováno v:
Blood. 132:213-213
Phosphoinositide signaling is central to many cellular processes including the cell survival pathway known as autophagy. While there is evidence that autophagy can suppress tumorigenesis under certain circumstances, there is increasingly abundant evi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::867bf56f13fc1acc910e2fea63856a46
https://doi.org/10.1182/blood-2018-99-118355
https://doi.org/10.1182/blood-2018-99-118355
Autor:
Hugo Gutiérrez-de-Terán, Helena Åkerberg, Dan Larhammar, Ingrid Lundell, Helena Fällmar, Lars Boukharta, Paula Sjödin, Nina Mohell
Publikováno v:
Regulatory Peptides. 163:120-129
Neuropeptide Y (NPY) and peptide YY (PYY) share approximately 70% of their 36 amino acids and bind to the same three human receptor subtypes, Y1, Y2 and Y5, even though these receptors only share approximately 30% sequence identity. Based on our prev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c0e5e1e948e0e5fa81fb0f59975cbd94
https://doi.org/10.1016/j.regpep.2010.04.011
https://doi.org/10.1016/j.regpep.2010.04.011
Publikováno v:
Biochemistry. 48:1743-1753
Horizontal DNA transfer between bacteria is widespread and a major cause of antibiotic resistance. For logistic reasons, single or combined genes are shuttled between vectors such as plasmids and bacterial chromosomes. Special elements termed integro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8115415a1ee7af3588db521cc0b97223
https://doi.org/10.1021/bi8020235
https://doi.org/10.1021/bi8020235
Publikováno v:
Journal of Medicinal Chemistry. 51:2657-2667
To produce reliable predictions of bioactive conformations is a major challenge in the field of structure-based inhibitor design and is a requirement for accurate binding free energy predictions with structure-based methods. A series of HIV-1 reverse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2429c7e550937ef4bdd2182839e0d95b
https://doi.org/10.1021/jm701218j
https://doi.org/10.1021/jm701218j
Publikováno v:
Journal of Medicinal Chemistry. 51:2648-2656
Docking, scoring, molecular dynamics (MD), and the linear interaction energy (LIE) method are used here to predict binding modes and affinities for a set of 43 non-nucleoside inhibitors to HIV-1 reverse transcriptase. Starting from a crystallographic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8f973d3bb701a98c902632ec5d4d91e
https://doi.org/10.1021/jm7012198
https://doi.org/10.1021/jm7012198