Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Lars Binkle"'
Autor:
Ingo Winschel, Anne Willing, Jan Broder Engler, Mark Walkenhorst, Nina Meurs, Lars Binkle-Ladisch, Marcel S. Woo, Lena Kristina Pfeffer, Jana K. Sonner, Uwe Borgmeyer, Sven Hendrik Hagen, Benjamin Grünhagel, Janna M. Claussen, Marcus Altfeld, Manuel A. Friese
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-20 (2024)
Abstract Background Differences in immune responses between women and men are leading to a strong sex bias in the incidence of autoimmune diseases that predominantly affect women, such as multiple sclerosis (MS). MS manifests in more than twice as ma
Externí odkaz:
https://doaj.org/article/567ad8ca738140ac904d3852d72995df
Autor:
Undine Haferkamp, Narasimha Telugu, Kim Krieg, Wiebe Schaefer, Dennis Lam, Lars Binkle-Ladisch, Manuel A. Friese, Sebastian Diecke, Ole Pless
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103609- (2024)
Two isogenic hiPSC lines, ZIPi013-B-1 and ZIPi013-B-2, were generated by CRISPR/Cas9-mediated indels in the TRPM4 gene of the previously published ZIPi013-B. TRPM4 belongs to the evolutionarily conserved family of transient receptor potential (TRP) c
Externí odkaz:
https://doaj.org/article/f15cd7cb53b64c50afe05c17fc33c3ae
Autor:
Brenna C. Fearey, Lars Binkle, Daniel Mensching, Christian Schulze, Christian Lohr, Manuel A. Friese, Thomas G. Oertner, Christine E. Gee
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract The transient receptor potential melastatin 4 (TRPM4) channel contributes to disease severity in the murine experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis and to neuronal cell death in models of excitotoxicity an
Externí odkaz:
https://doaj.org/article/3bd731c3c1254a9889512194675bf219
Publikováno v:
Molecular Brain, Vol 15, Iss 1, Pp 1-11 (2022)
Abstract SorLA is a member of the Vps10p-domain (Vps10p-D) receptor family of type-I transmembrane proteins conveying neuronal endosomal sorting. The extracellular/luminal moiety of SorLA has a unique mosaic domain composition and interacts with a la
Externí odkaz:
https://doaj.org/article/c19f96be23164ff8b580d668e8eb726c
Autor:
Marcel Klein, Abuzar Kaleem, Sandra Oetjen, Daniela Wünkhaus, Lars Binkle, Sandra Schilling, Milena Gjorgjieva, Ralf Scholz, Doris Gruber-Schoffnegger, Stephan Storch, Stefan Kins, Gerard Drewes, Sabine Hoffmeister-Ullerich, Dietmar Kuhl, Guido Hermey
Publikováno v:
Autophagy. 18(9)
PSENEN/PEN2 is the smallest subunit of the γ-secretase complex, an intramembrane protease that cleaves proteins within their transmembrane domains. Mutations in components of the γ-secretase underlie familial Alzheimer disease. In addition to its p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90fe3c4fe2dcef4110346d20f2bf3b9b
https://pubmed.ncbi.nlm.nih.gov/34964690
https://pubmed.ncbi.nlm.nih.gov/34964690
Autor:
Christine E. Gee, Manuel A. Friese, Christian Lohr, Thomas G. Oertner, Brenna C. Fearey, Lars Binkle, Christian H. Schulze, Daniel Mensching
The transient receptor potential melastatin 4 (TRPM4) channel contributes to disease severity in the murine experimental autoimmune encephalomyelitis (EAE) model of multiple sclerosis and to neuronal cell death in models of excitotoxicity and traumat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c9e49669421bcf6d803928cfb3889c6f
https://doi.org/10.21203/rs.3.rs-860782/v1
https://doi.org/10.21203/rs.3.rs-860782/v1
Autor:
Simone Bauer, Jan Broder Engler, Nina Kursawe, Marcel S Woo, Michael Moles, Friederike Ufer, Britta Huscher, Elena Montes-Cobos, Lars Binkle, Manuel A. Friese
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 205(11)
The voltage-gated proton channel Hv1 regulates proton fluxes across membranes, thereby influencing pH-dependent processes. Plasmacytoid dendritic cells (pDCs) require a particularly tight regulation of endosomal pH to ensure strong type I IFN secreti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e82456f3a46fb03c3bd4219f01b72287
https://pubmed.ncbi.nlm.nih.gov/33127821
https://pubmed.ncbi.nlm.nih.gov/33127821
Autor:
Sabine Graf, Dietmar Kuhl, Ora Ohana, Ute Süsens, Sergio Castro-Gomez, Dirk Isbrandt, Jasper Grendel, Daniel Mensching, Xiaoyan Gao, Lars Binkle
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America 115(49), 12531-12536 (2018). doi:10.1073/pnas.1810125115
During early postnatal development, sensory regions of the brain undergo periods of heightened plasticity which sculpt neural networks and lay the foundation for adult sensory perception. Such critical periods were also postulated for learning and me
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eb51dd33955d0b6e82fd65d4e58f22ac
https://pub.dzne.de/record/140363
https://pub.dzne.de/record/140363
Autor:
Ole Pless, Undine Haferkamp, Nicola Rothammer, Robert M. Duvoisin, Jan Broder Engler, Jacob Raber, Kristof Egervari, Sönke Hornig, Doron Merkler, Manuel A. Friese, Ingrid Wagner, Simone Bauer, Lars Binkle, Marcel S Woo, Giovanni Di Liberto, Jana K. Sonner, Friederike Ufer
Publikováno v:
Journal of Experimental Medicine, Vol. 218, No 5 (2021) P. e20201290
The Journal of Experimental Medicine
The Journal of Experimental Medicine
Systematic analysis of the neuronal receptor interactome in multiple sclerosis brains reveals the metabotropic glutamate receptor 8 as a disbalanced hub. Its activation constitutes a novel treatment strategy to enhance neuronal resilience by inhibiti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3313156215e46ddd5db24e8d15944406