Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Lars Becker"'
Autor:
Tian Wang, Tian Yang, Amanda Kedaigle, Gabriela Pregernig, Ryan McCarthy, Ben Holmes, Xudong Wu, Lars Becker, Ning Pan, Kathy So, Leon Chen, Jun He, Ahmad Mahmoudi, Soumya Negi, Monika Kowalczyk, Tyler Gibson, Noah Druckenbrod, Alan G. Cheng, Joseph Burns
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Vestibular hair cells are mechanoreceptors critical for detecting head position and motion. In mammals, hair cell loss causes vestibular dysfunction as spontaneous regeneration is nearly absent. Constitutive expression of exogenous ATOH1, a
Externí odkaz:
https://doaj.org/article/503dc5dba4e848548e5f4dec011e0c8f
Autor:
Jonathan B. Sellon, Kathy S. So, Andrew D'Arcangelo, Sarah Cancelarich, Meghan C. Drummond, Peter G. Slade, Ning Pan, Tyler M. Gibson, Tian Yang, Joseph C. Burns, Adam T. Palermo, Lars Becker
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
Deafness-causing deficiencies in otoferlin (OTOF) have been addressed preclinically using dual adeno-associated virus (AAV)-based approaches. However, timing of transduction, recombination of mRNA, and protein expression with dual hybrid AAV methods
Externí odkaz:
https://doaj.org/article/a844378fd26b47b3b6c0c1450c88a3a4
Autor:
Katharina Fetz, Gina Grimaldi, Dan Bieler, Anne Neubert, Carina Jaekel, Christine Hoefer, Elisabeth Schwojer, Stefanie Bartha, Jean-Jacques Glaesener, Lars Becker, Lisa Wienhoefer, Rolf Lefering, LeAf-Trauma Study Group
Publikováno v:
PLoS ONE, Vol 19, Iss 11, p e0312320 (2024)
With increasing survival rates, the functional outcome and quality of life of trauma patients are gaining more importance. Survivors suffer from chronic pain, psychosomatic disorders, and unemployment as well as increased post-traumatic morbidity, wh
Externí odkaz:
https://doaj.org/article/23fb40fefc7c46f1af36d5643dae4ea4
Publikováno v:
Systematic Reviews, Vol 8, Iss 1, Pp 1-6 (2019)
Abstract Background Actinic keratoses (AK) are common precancerous lesions of the skin due to cumulative sun exposure. A variety of interventions are available for the treatment; however, the majority of randomised controlled trials (RCTs) and meta-a
Externí odkaz:
https://doaj.org/article/e6a7f0785f8a4ba08518a40d939b89f5
Autor:
Christina Polan, Heinz-Lothar Meyer, Manuel Burggraf, Monika Herten, Paula Beck, Henrik Braitsch, Lars Becker, Carsten Vogel, Marcel Dudda, Max Daniel Kauther
Publikováno v:
Geriatric Orthopaedic Surgery & Rehabilitation, Vol 12 (2021)
Background: The COVID-19 pandemic is challenging healthcare systems worldwide. This study examines geriatric patients with proximal femur fractures during the COVID-19 pandemic, shifts in secondary disease profile, the impact of the pandemic on hospi
Externí odkaz:
https://doaj.org/article/39ec0a792b0b4f1e903e59eb826ad9dd
Autor:
Lars Ellenrieder, Łukasz Opaliński, Lars Becker, Vivien Krüger, Oliver Mirus, Sebastian P. Straub, Katharina Ebell, Nadine Flinner, Sebastian B. Stiller, Bernard Guiard, Chris Meisinger, Nils Wiedemann, Enrico Schleiff, Richard Wagner, Nikolaus Pfanner, Thomas Becker
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
The protein Mdm10 is known to be present in the endoplasmic reticulum-mitochondria encounter structure (ERMES) and in mitochondrial sorting and assembly machinery (SAM). Here, the authors examine how this protein interacts with SAM and EMRES, showing
Externí odkaz:
https://doaj.org/article/9bf2b01669244292939e16b34fde2489
Autor:
Lars Becker, Michael E Schnee, Mamiko Niwa, Willy Sun, Stephan Maxeiner, Sara Talaei, Bechara Kachar, Mark A Rutherford, Anthony J Ricci
Publikováno v:
eLife, Vol 7 (2018)
The ribbon is the structural hallmark of cochlear inner hair cell (IHC) afferent synapses, yet its role in information transfer to spiral ganglion neurons (SGNs) remains unclear. We investigated the ribbon’s contribution to IHC synapse formation an
Externí odkaz:
https://doaj.org/article/5c3ed910393a4578ac965be0a8cadbb6
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e58174 (2013)
TRPML3 and TRPV5 are members of the mucolipin (TRPML) and TRPV subfamilies of transient receptor potential (TRP) cation channels. Based on sequence similarities of the pore forming regions and on structure-function evidence, we hypothesized that the
Externí odkaz:
https://doaj.org/article/420f1b0f864847c3821b496b1e65db18
Publikováno v:
PLoS ONE, Vol 5, Iss 12, p e14317 (2010)
TRPML3, a member of the transient receptor potential (TRP) family, is an inwardly rectifying, non-selective Ca2+-permeable cation channel that is regulated by extracytosolic Na+ and H+ and can be activated by a variety of small molecules. The severe
Externí odkaz:
https://doaj.org/article/2b52b4f5e28f4c8e93e27caa8df95173
Autor:
Grazyna Domańska, Christian Motz, Michael Meinecke, Anke Harsman, Panagiotis Papatheodorou, Boris Reljic, Elke A Dian-Lothrop, Antoine Galmiche, Oliver Kepp, Lars Becker, Kathrin Günnewig, Richard Wagner, Joachim Rassow
Publikováno v:
PLoS Pathogens, Vol 6, Iss 4, p e1000878 (2010)
The vacuolating toxin VacA, released by Helicobacter pylori, is an important virulence factor in the pathogenesis of gastritis and gastroduodenal ulcers. VacA contains two subunits: The p58 subunit mediates entry into target cells, and the p34 subuni
Externí odkaz:
https://doaj.org/article/a4b5be66caac4e40b235c363349940c3