Stereoselective Oxidative Bioconjugation of Amino Acids and Oligopeptides to Aldehydes

Autor: Henriette N. Tobiesen, Lars A. Leth, Marc V. Iversen, Line Næsborg, Søren Bertelsen, Karl Anker Jørgensen

Publikováno v: Tobiesen, H N, Leth, L A, Iversen, M V, Naesborg, L, Bertelsen, S & Jørgensen, K A 2020, ' Stereoselective Oxidative Bioconjugation of Amino Acids and Oligopeptides to Aldehydes ', Angewandte Chemie-International Edition, vol. 59, no. 42, pp. 18490-18494 . https://doi.org/10.1002/anie.202008513

The first stereoselective, near-equimolar, and metal-free oxidative bioconjugation of amino acids and oligopeptides to aldehydes is presented. Based on a newly developed organocatalytic oxidative concept, the C-terminal and side-chain carboxylic acid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59ff85dca704c2e55a5f42056bd082be
https://doi.org/10.1002/anie.202008513

Direct Enantio- and Diastereoselective Oxidative Homocoupling of Aldehydes

Autor: Gabriel J. Reyes-Rodríguez, Line Næsborg, Teresa A. Palazzo, Karl Anker Jørgensen, Lars A. Leth, Vasco Corti

Publikováno v: Næsborg, L, Leth, L, Reyes Rodriguez, G J, Palazzo, T A & Jørgensen, K A 2018, ' Direct Enantio- and Diastereoselective Oxidative Homo-Coupling of Aldehydes ', Chemistry: A European Journal, vol. 24, no. 55, pp. 14844-14848 . https://doi.org/10.1002/chem.201803506

A novel strategy for the direct enantioselective oxidative homocoupling of α-branched aldehydes is presented. The methodology employs open-shell intermediates for the construction of chiral 1,4-dialdehydes by forming a carbon–carbon bond connectin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c82e7d8cc6cc837f651c23e1e6e7dedc
https://doi.org/10.1002/chem.201803506

Enantioselective Oxidative Coupling of Carboxylic Acids to α-Branched Aldehydes

Autor: Lars A. Leth, Gabriel J. Reyes-Rodríguez, Henriette N. Tobiesen, Line Næsborg, Marc V. Iversen, Karl Anker Jørgensen

Publikováno v: Leth, L A, Næsborg, L, Reyes-Rodríguez, G J, Tobiesen, H N, Iversen, M V & Jørgensen, K A 2018, ' Enantioselective Oxidative Coupling of Carboxylic Acids to α-Branched Aldehydes ', Journal of the American Chemical Society, vol. 140, no. 40, pp. 12687-12690 . https://doi.org/10.1021/jacs.8b07394

A new reactivity in organocatalysis is proposed to account for the coupling of carboxylic acids to α-branched aldehydes by combining primary amine catalysis and an oxidant. The developed methodology is an enantioselective α-coupling of aromatic and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5cf2b1f0954ac26edbb8762ffdfc3ad9
https://pure.au.dk/portal/da/publications/enantioselective-oxidative-coupling-of-carboxylic-acids-to-branched-aldehydes(d8d0d027-ad3a-454f-8f4a-7886a5f906bc).html

Indium(III)-catalyzed Aza-Conia-Ene Reaction for the Synthesis of Indolizines

Autor: Marta Meazza, Jeremy D. Erickson, Karl Anker Jørgensen, Lars A. Leth

Publikováno v: Meazza, M, Leth, L A, Erickson, J D & Jørgensen, K A 2017, ' Indium(III)-catalyzed Aza-Conia-Ene Reaction for the Synthesis of Indolizines ', Chemistry: A European Journal, vol. 23, no. 33, pp. 7905-7909 . https://doi.org/10.1002/chem.201701820

A new indium(III)-catalyzed reaction for the synthesis of a series of indolizine scaffolds has been developed. This methodology was highly efficient, allowing a low catalyst loading of 2 mol % (down to 0.5 mol %) and rendering the products in high yi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d5fe632e9c1013edc21ff43ec9cc3214
https://pubmed.ncbi.nlm.nih.gov/28444826

Oxadendralenes in asymmetric organocatalysis for the construction of tetrahydroisochromenes

Autor: Julian Stiller, Lars A. Leth, Niels Hammer, Magnus E. Jensen, Karl Anker Jørgensen

Publikováno v: Hammer, N, Leth, L, Stiller, J, Jensen, M E & Jørgensen, K A 2016, ' Oxadendralenes in asymmetric organocatalysis for the construction of tetrahydroisochromenes ', Chemical Science, pp. 3649-3657 . https://doi.org/10.1039/C6SC00185H

Oxadendralenes are integrated in a novel manner into a one-pot cascade utilizing synergistic catalysis for the construction of valuable and complex bicyclic heterocyclic scaffolds. The construction is based on the organocatalytic activation of the ox

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41a2e8468b84e708816abb24c6bd87c9
https://pure.au.dk/ws/files/119029931/c6sc00185h.pdf