Running in mice increases the expression of brain hemoglobin-related genes interacting with the GH/IGF-1 system

Autor: Marion Walser, Lars Karlsson, Reza Motalleb, Jörgen Isgaard, H. Georg Kuhn, Johan Svensson, N. David Åberg

Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-10 (2024)

Abstract The beneficial effects of exercise are partly mediated via local or systemic functions of the insulin-like growth factor-1 (IGF-1) system. As IGF-1 increases local brain hemoglobin beta (Hbb) transcripts, we hypothesized that exercise could

Externí odkaz: https://doaj.org/article/ed0426bbc6d54de8a86d6ae0cde30f72

Brain tissue haemoglobin expression in saline-perfused vs non-perfused rodents

Autor: Marion Walser, Lars Karlsson, Reza Motalleb, Jörgen Isgaard, H Georg Kuhn, N. David Åberg

Publikováno v: Heliyon, Vol 10, Iss 1, Pp e23343- (2024)

Haemoglobin beta (Hbb) and delta-aminolevulinate synthase 2 (Alas2) messenger RNA (mRNA) is mainly found in immature red blood cells, reticulocytes, and not in mature erythrocytes. However, these are also expressed in other tissues such as brain cell

Externí odkaz: https://doaj.org/article/f1fbe22d01e84b95a9ccc22dd8e070b3

Constitutive PGC-1α overexpression in skeletal muscle does not protect from age-dependent decline in neurogenesis

Autor: Lars Karlsson, María Nazareth González-Alvarado, Reza Motalleb, Klas Blomgren, Mats Börjesson, Hans Georg Kuhn

Publikováno v: Scientific Reports, Vol 9, Iss 1, Pp 1-11 (2019)

Abstract Aerobic exercise prevents age-dependent decline in cognition and hippocampal neurogenesis. The transcription factor peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) mediates many of the exercise-induced benefit

Externí odkaz: https://doaj.org/article/74f670ac4f37438ab1c911718eab4057

Algorithm 1026: Concurrent Alternating Least Squares for Multiple Simultaneous Canonical Polyadic Decompositions

Autor: Christos Psarras, Lars Karlsson, Rasmus Bro, Paolo Bientinesi

Publikováno v: Psarras, C, Karlsson, L, Bro, R & Bientinesi, P 2022, ' Algorithm 1026 : Concurrent Alternating Least Squares for Multiple Simultaneous Canonical Polyadic Decompositions ', ACM Transactions on Mathematical Software, vol. 48, no. 3, 34 . https://doi.org/10.1145/3519383

Tensor decompositions, such as CANDECOMP/PARAFAC (CP), are widely used in a variety of applications, such as chemometrics, signal processing, and machine learning. A broadly used method for computing such decompositions relies on the Alternating Leas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a22305df4cb53a6e9c0c51ab81191f60
https://doi.org/10.1145/3519383

Combining a hip arthroplasty stem with trochanteric reattachment bolt and a polyaxial locking plate in the treatment of a periprosthetic fracture below a well-integrated implant

Autor: Urban Hedlundh, Lars Karlsson

Publikováno v: Arthroplasty Today, Vol 2, Iss 4, Pp 141-145 (2016)

Distally anchored uncemented modular tapered porous stems are often the preferred treatment in total hip arthroplasty revisions and failed subtrochanteric fractures. These conditions mainly affect elderly osteoporotic patients, with an increased risk

Externí odkaz: https://doaj.org/article/ef9cec6326b14a62b8ee561990c84fee