Zobrazeno 1 - 10
of 26
pro vyhledávání: '"Lars Öhman"'
Autor:
Amanda K Mika, Terry J. Opgenorth, Lars Öhman, Denise Wilcox, Bradley A. Zinker, Phong T. Nguyen, Thomas W. von Geldern, Peer B. Jacobson
Publikováno v:
Metabolism. 56:380-387
It is unclear how hepatic glucocorticoid receptor (GR) function and hypothalamic-pituitary-adrenal axis tone contribute to the diabetic state and in particular whole-body glucose fluxes. We have previously demonstrated that long-term exposure to hepa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::03046092bf330b85e7520eb28d62f8f5
https://doi.org/10.1016/j.metabol.2006.10.021
https://doi.org/10.1016/j.metabol.2006.10.021
Autor:
Peer B. Jacobson, Lars Öhman, Birgitta Gelius, Marlena Grynfarb, Annika Goos-Nilsson, Richards Steven J, Masha Kalmanovich, Steven Fung, Thomas W. von Geldern, Denise Wilcox, Marie K. Österlund, Phong Nguyen, Jiahong Wang
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 16:6086-6090
A series of potent steroidal glucocorticoid receptor antagonists has been discovered. After conjugation to cholic acid, the compounds retained an affinity for GR in vitro and had modest in vivo efficacy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dec174e400bfc6de41f692b71623b9dd
https://doi.org/10.1016/j.bmcl.2006.08.133
https://doi.org/10.1016/j.bmcl.2006.08.133
Autor:
Karin Calles, Steven W. Muchmore, Anna Karin Ramqvist, Mats Carlquist, Jie Yang, Maria Alarcon, Jan Carlstedt-Duke, Owe Engström, John M. Harlan, Jan-Åke Gustafsson, Susanne Thorell, Harri Ahola, Björn Kauppi, Jonathan Greer, Clarissa G. Jakob, Lars Öhman, Mathias Färnegårdh
Publikováno v:
Journal of Biological Chemistry. 278:22748-22754
Here we describe the three-dimensional crystal structures of human glucocorticoid receptor ligand-binding domain (GR-LBD) in complex with the antagonist RU-486 at 2.3 A resolution and with the agonist dexamethasone ligand together with a coactivator
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f444909f0a2cf476ffd1d0faf533bcf3
https://doi.org/10.1074/jbc.m212711200
https://doi.org/10.1074/jbc.m212711200
Publikováno v:
Biotechnology Progress. 16:837-846
Cell cycle progression was studied in serum-free batch cultures of Spodoptera frugiperda (Sf9) insect cells, and the implications for proliferation and productivity were investigated. Cell cycle dynamics in KBM10 serum-free medium was characterized b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd52ab6b07d790948b2883e3ce0004a1
https://doi.org/10.1021/bp000108i
https://doi.org/10.1021/bp000108i
Publikováno v:
Journal of Biotechnology. 59:103-115
The physiology of cultured animal cells, in particular hybridoma, myeloma and insect cells, with respect to growth and proliferation, amino acid metabolism, energy metabolism and cellular responses to environmental stress is discussed in this paper.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::498a1a484c76c23366aa069dde39d0d2
https://doi.org/10.1016/s0168-1656(97)00172-7
https://doi.org/10.1016/s0168-1656(97)00172-7
Autor:
Kerstin Andersson, Tomas Barkhem, Göran Andersson, Barbro Ek-Rylander, Lars Öhman, Jenny Ljusberg
Publikováno v:
Biochemical Journal. 321:305-311
The tartrate-resistant acid phosphatase (TRAP) of rat osteoclasts has been shown to exhibit high (85Ő94%) identity at the amino acid sequence level with the purple acid phosphatase (PAP) from bovine spleen and with pig uteroferrin. These iron-contai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b699beced637d2c663ae0c3fe414968b
https://doi.org/10.1042/bj3210305
https://doi.org/10.1042/bj3210305
Publikováno v:
Biotechnology Letters. 18:765-770
Spodoptera frugiperda (Sf-9) insect cells are fully capable of growth and proliferation in a glutamine, glutamate and aspartate-free medium, provided that ammonium ions are supplied. S. frugiperda (Sf-21) and Mamestra brassicae cells (IZD-MB-0503) al
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::35ea044f66bb796105acbdfcad9ec5b8
https://doi.org/10.1007/bf00127885
https://doi.org/10.1007/bf00127885
Publikováno v:
Annals of the New York Academy of Sciences. 782:40-52
Substrate-limited fed-batch cultures were used to study growth and overflow metabolism in hybridoma and insect cells. In hybridoma cells a glucose-limited fed-batch culture decreased lactate formation but increased glutamine consumption and ammonium
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df448614353bfab2b55e8db0bde102b1
https://doi.org/10.1111/j.1749-6632.1996.tb40545.x
https://doi.org/10.1111/j.1749-6632.1996.tb40545.x
Autor:
Doss W. Neal, Peer B. Jacobson, David W. A. Beno, Melanie Scott, T. J. Opgenorth, Alan D. Cherrington, Dale S. Edgerton, Tom von Geldern, Bradley A. Zinker, Lars Öhman
Publikováno v:
Metabolism: clinical and experimental. 55(9)
A liver-selective glucocorticoid (GC) receptor antagonist (A-348441) was used to determine the effect of reduced hepatic GC signaling on hepatic glucose production. Fasted conscious dogs were studied in the presence (GRA, n = 6) or absence (CON, n =
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a2e397c3486f4d432edcd08bf82caec2
https://pubmed.ncbi.nlm.nih.gov/16919547
https://pubmed.ncbi.nlm.nih.gov/16919547
Autor:
T. J. Opgenorth, Bach Nga-Nguyen, Annika Goos-Nilsson, Denise Wilcox, J.T. Link, Bradley A. Zinker, David W. A. Beno, Tomas Barkhem, Kennan C. Marsh, Thomas A. Fey, Peer B. Jacobson, Marie Österland, Suad Efendic, Philip R. Kym, Dale S. Edgerton, Steven Fung, Thomas W. von Geldern, Marlena Grynfarb, Lars Öhman, Noah Tu, Phong Nguyen, Benjamin C. Lane, Alan D. Cherrington, Jiahong Wang, Amanda K Mika
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 314(1)
Glucocorticoids amplify endogenous glucose production in type 2 diabetes by increasing hepatic glucose output. Systemic glucocorticoid blockade lowers glucose levels in type 2 diabetes, but with several adverse consequences. It has been proposed, but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::066d09624f90cab2075997cde744d32b
https://pubmed.ncbi.nlm.nih.gov/15784656
https://pubmed.ncbi.nlm.nih.gov/15784656